davidgriwatz.bsky.social
David Griwatz
@davidgriwatz.bsky.social
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PhD Student in Hänelt Lab, Frankfurt
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David Griwatz @davidgriwatz.bsky.social · May 13
Proud to share this great story is out now! A huge Thank You to the whole team but especially to my co-first author Janina Stautz. The results were often surprising but we managed to unpuzzle how a short IDR and its membrane interaction are involved in channel opening.
ihaenelt.bsky.social
Inga Hänelt @ihaenelt.bsky.social · May 12
This took us a while and I am all the happier it is finally out! I thought that simply adding ATP to purified potassium channel KtrAB should be sufficient to stabilize its active state. I was so wrong...
Read the full story on how an IDR facilitates channel opening upon membrane interaction.
A short intrinsically disordered region at KtrB’s N-terminus facilitates allosteric regulation of K+ channel KtrAB
Nature Communications - KtrAB is a major potassium uptake system that has been linked to the pathogenesis of many infectious bacteria. Here the authors show that KtrB from Vibrio alginolyticus...
www.nature.com
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