On the theory side, Yuhai Tu, @qiweiyu.bsky.social, and I developed a decomposition of the covariance between expressed RNA molecules into extrinsic and intrinsic components and we introduced a minimal stochastic model for the expression statistics resulting from coupled gene activation.

The experiments utilized a synthetic topologically controllable chromosomal domain. Combined with gyrase and topoisomerase inhibitors, this allowed us to measure how domain formation and DNA supercoiling modulate expression level and correlations between expression of neighboring genes.

Finally, I will be hiring at all levels starting next fall. Keep an eye out for a postdoc job posting in the coming days, but interested candidates are welcome to reach out now. Prospective grad students can apply to the UofT physics department (deadline: Dec 12th).

Enormous gratitude to the mentors and collaborators who have made this journey possible, most significantly: Yuhai Tu, @stevenstrogatz.com, Jim Sethna, and Mike Hinczewski

In the meantime I am at the Flatiron Institute in the Center for Computational Biology—if you are in NYC and want to talk science please reach out!