Denise Ohnezeit
deniseohnezeit.bsky.social
Denise Ohnezeit
@deniseohnezeit.bsky.social
Postdoc @NYU Medical School
New paper from our lab led by Shirley Braspenning! Happy to have contributed.

We show that TDP-43, a key neuronal disease factor, promotes HSV-1 gene expression and splicing in neuron-derived cells. Find out more here:

doi.org/10.1128/jvi....
TDP-43 promotes efficient HSV-1 replication in human DRG-derived neurons | Journal of Virology
Herpes simplex virus type-1 is a widespread neurotropic pathogen that can cause life-threatening infections of the brain and is increasingly linked to neurodegenerative disease. However, due to the la...
doi.org
December 11, 2025 at 3:07 AM
Reposted by Denise Ohnezeit
Checkout our new preprint (www.biorxiv.org/content/10.1...) where we optimize Dorado on RNA from multiple cell types and directly compare to GLORI-seq.
Establishing benchmarks for quantitative mapping of m6A by Nanopore Direct RNA Sequencing
Nanopore direct RNA sequencing (DRS) coupled with Dorado modification-aware basecalling enables mapping of epitranscriptomic modifications including N6-methyladenosine (m6A) at the level of individual...
www.biorxiv.org
November 11, 2025 at 12:35 AM