di Bernardo Lab
@diegodibi.bsky.social
#Syntheticbiology to advance gene and cell therapy in rare genetic disease is our major focus. We rely on biomedical engineering, molecular biology and bioinformatics to achieve this goal. https://dibernardo.tigem.it
Not very surprising…
September 26, 2025 at 7:31 AM
Not very surprising…
Reposted by di Bernardo Lab
The team is already working to expand the platform’s abilities, including testing in clinically relevant immune and stem cells, and engineering future versions of the system that can rearrange sequences beyond one megabase.
Learn more in the full paper: www.science.org/doi/10.1126/...
Learn more in the full paper: www.science.org/doi/10.1126/...
Megabase-scale human genome rearrangement with programmable bridge recombinases
Bridge recombinases are naturally occurring RNA-guided DNA recombinases that we previously demonstrated can programmably insert, excise, and invert DNA in vitro and in Escherichia coli. In this study,...
www.science.org
September 25, 2025 at 6:27 PM
The team is already working to expand the platform’s abilities, including testing in clinically relevant immune and stem cells, and engineering future versions of the system that can rearrange sequences beyond one megabase.
Learn more in the full paper: www.science.org/doi/10.1126/...
Learn more in the full paper: www.science.org/doi/10.1126/...