Diego A. Pacheco Pinedo
@dipacheco.bsky.social
Using flies to study neural computations @harvardmed.bsky.social | PhD in Neuroscience @Princeton | B.S. @UNMSM_
Reposted by Diego A. Pacheco Pinedo
Delighted to share an updated pre-print on how adaptive control in visual pursuit is implemented at the circuit level. New behavior and neuronal data in females (!) shows how two AOTU pathways are key elements in both sexes.
Check it out on @biorxiv-neursci.bsky.social :
doi.org/10.1101/2025...
Check it out on @biorxiv-neursci.bsky.social :
doi.org/10.1101/2025...
Specialized parallel pathways for adaptive control of visual object pursuit
To pursue a moving visual object, the brain must generate motor commands that continuously steer the object to the center of the visual field via feedback. The gain of this control loop is flexible, y...
doi.org
November 3, 2025 at 4:58 PM
Delighted to share an updated pre-print on how adaptive control in visual pursuit is implemented at the circuit level. New behavior and neuronal data in females (!) shows how two AOTU pathways are key elements in both sexes.
Check it out on @biorxiv-neursci.bsky.social :
doi.org/10.1101/2025...
Check it out on @biorxiv-neursci.bsky.social :
doi.org/10.1101/2025...
Reposted by Diego A. Pacheco Pinedo
How is the nervous system organized to coordinate behavior? To approach this massive question, a team led by @asbates.bsky.social, @jasper-tms.bsky.social, @mindyisminsu.bsky.social, & Helen Yang present the BANC: a Brain and Nerve Cord connectome.
Preprint: doi.org/10.1101/2025...
🧪#Neuroskyence
Preprint: doi.org/10.1101/2025...
🧪#Neuroskyence
August 3, 2025 at 3:16 PM
How is the nervous system organized to coordinate behavior? To approach this massive question, a team led by @asbates.bsky.social, @jasper-tms.bsky.social, @mindyisminsu.bsky.social, & Helen Yang present the BANC: a Brain and Nerve Cord connectome.
Preprint: doi.org/10.1101/2025...
🧪#Neuroskyence
Preprint: doi.org/10.1101/2025...
🧪#Neuroskyence
Thrilled to have been part of this amazing team and to get an early, hands-on look at such a unique and rich full-brain and cord dataset. Congratulations to everyone involved in this large collaborative effort!
Public access to the first fly connectome that spans the whole CNS - BANC!: codex.flywire.ai?dataset=banc
Different from prior connectomes - it is brain + cord (think spinal cord)
We use it to ‘embody’ the system and find it resembles ‘subsumption architecture’ doi.org/10.1101/2025...
Different from prior connectomes - it is brain + cord (think spinal cord)
We use it to ‘embody’ the system and find it resembles ‘subsumption architecture’ doi.org/10.1101/2025...
August 4, 2025 at 3:13 PM
Thrilled to have been part of this amazing team and to get an early, hands-on look at such a unique and rich full-brain and cord dataset. Congratulations to everyone involved in this large collaborative effort!
Reposted by Diego A. Pacheco Pinedo
Many animals use "adaptive control" to pursue moving objects, relying on flexible feedback loops to adjust their movement gain over time. But how do neural circuits actually implement this?
Here, we show how adaptive control in Drosophila pursuit involves two specialized parallel feedback loops.
Here, we show how adaptive control in Drosophila pursuit involves two specialized parallel feedback loops.
Specialized parallel pathways for adaptive control of visual object pursuit
To pursue an unpredictably moving visual object, the brain must generate motor commands that continuously steer the object to the midline of the visual field via feedback. Behavior implies that visual...
doi.org
April 28, 2025 at 3:19 PM
Many animals use "adaptive control" to pursue moving objects, relying on flexible feedback loops to adjust their movement gain over time. But how do neural circuits actually implement this?
Here, we show how adaptive control in Drosophila pursuit involves two specialized parallel feedback loops.
Here, we show how adaptive control in Drosophila pursuit involves two specialized parallel feedback loops.