Litmus test them for being magat and/or anti-scientific method. DO NO HARM doesn’t mean you cannot choose to do nothing. Curate your patients and let nature take its course.
It’s easier to amass 22 mgnm, as the 5.S6/.2Z3 are 2x+ more per round. Plus, in more densely populated areas it can some be hard to find a place to practice with a CF rifle round .. but much more likely, and frequently, with a RF rifle round.
AR-15 platform question .. as far as just defending one’s home, one’s castle, standing ON your ground, purely response-defensive .. why not .22 WMR (magnum cal.) instead of the full-on standard 5.56?