Lightnews — Scholar-powered news

DjuranovicLab at Brown University RNA Center

@djuranoviclab.bsky.social

900 followers 210 following 64 posts

RNA, Ribosome, miRNA, mRNA, translation, translational control, sometimes splicing

Posts Media Videos Starter Packs

Pinned

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Aug 5

Our RAPPL purification of ribosomes and associated material is out. I am really proud of this study in collaboration primary with Pavlovic-Djuranovic lab, as well as Jovanovic and Hashem Labs. This method aims to replace 60 years old purification of ribosomes by sucrose cushions

rdcu.be/ezlhg

A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies

Nature Communications - Here, the authors present a method to rapidly isolate actively translating ribosomes in a time- and cost-effective manner using poly-lysine. The method is compatible with a...

rdcu.be

1 21 51

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 9d

A short synopsis of a recent Symposium at Brown University and inaugural Giuliani RNA Center meeting. It was an honor to be part of it.

www.brown.edu/news/2025-09...

Researchers, industry leaders convene at Brown to explore the potential of RNA

Brown’s Giuliani RNA Center and the Rhode Island Life Science Hub co-hosted a symposium focused on how scientists can work together to turn RNA discoveries into solutions.

www.brown.edu

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 24d

We are looking for a new postdoctoral fellow interested in the further development of our RAPPL technology and studies of translational complexes. Preference will be given to candidates with either structural biology or ribosome profiling backgrounds.

www.nature.com/articles/s41...

A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies - Nature Communications

Here, the authors present a method to rapidly isolate actively translating ribosomes in a time- and cost-effective manner using poly-lysine. The method is compatible with a wide variety of cell and ti...

www.nature.com

5 5

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 27d

Please join us for the Inaugural Brown RNA Center Symposium with a Keynote Speakers Melissa Moore and Craig Mello, guests Victor Dzau, Jack Reed and Subra Suresh, as well as more talks and panels including both scientific and industrial speakers and panelists.

sites.brown.edu/rna-symposium/

RNA Without Borders: Academic Insights, Industry Impact

Join research and industry leaders in RNA science for a dynamic symposium uniting cutting-edge innovation with real-world solutions for the health of people and planet. September 26-27, 2025The Warren...

sites.brown.edu

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Sep 3

Four days of science at
@events.embl.org
in Heidelberg for "Protein Synthesis and Translational Control" meeting.

1 6

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Aug 7

Thanks for invitation again.

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Aug 6

Thanks, and see you soon.

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Aug 5

This method not only saves time, but is also economical, more efficient and mild in isolation conditions, preserving translation complexes, ribosome associated proteins and enables isolation of ribosomes for structural (cryo-EM) and functional studies. More on RAPPL uses still to come...

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Aug 5

A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies

Nature Communications - Here, the authors present a method to rapidly isolate actively translating ribosomes in a time- and cost-effective manner using poly-lysine. The method is compatible with a...

rdcu.be

1 21 51

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Jul 25

Nice work

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Jul 25

Our collaboration with Tony Mustoe's lab us out today. MPRA libraries and possible cryptic splicing in MPRA reporters, or reporters in general. The additional novelty here is that such events are controlled or influenced by AU-rich sequences.

www.nature.com/articles/s41...

U-rich elements drive pervasive cryptic splicing in 3’ UTR massively parallel reporter assays - Nature Communications

Massively parallel reporter assays (MPRAs) are powerful technologies for measuring the impact of non-coding sequences on gene expression. Here, the authors demonstrate that MPRA reporters often underg...

www.nature.com

18 29

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Jul 15

First RAPPL ribosome isolation at the new lab space at Brown University. Purification from a small culture of parasitic Eukaryote. Soon out...
www.biorxiv.org/content/10.1...

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Jul 1

@djuranoviclab.bsky.social is from today officially part of Brown University and Brown RNA center. We will have our new website soon.

rna.brown.edu

The Brown RNA Center | Medical School | Brown University

Our mission is to advance RNA science through fundamental discovery, technology development, and translational impact that accelerates life-changing health solutions.

rna.brown.edu

1 1 10

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · May 8

Last month @uspto.bsky.social
issued yet another patent to Slavica Pavlovic Djuranovic, Jessey Erath and @djuranoviclab.bsky.social for use of polybasic peptide or non-peptide moieties against malaria parasites. More soon...

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Apr 28

Some of the ribosomes purified using RAPPL and Cryo-EM structures solved in last couple of months (6/6). Archaea #1

www.biorxiv.org/content/10.1...

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Apr 28

Some of the ribosomes purified using RAPPL and Cryo-EM structures solved in last couple of months (5/6). Eukaryotic #3

www.biorxiv.org/content/10.1...

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Apr 28

Some of the ribosomes purified using RAPPL and Cryo-EM structures solved in last couple of months (4/6). Eukaryotic #2

www.biorxiv.org/content/10.1...

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Apr 28

Some of the ribosomes purified using RAPPL and Cryo-EM structures solved in last couple of months (3/6). Eukaryotic #1

www.biorxiv.org/content/10.1...

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Apr 28

Some of the ribosomes purified using RAPPL and Cryo-EM structures solved in last couple of months (1/6). Bacterial #2

www.biorxiv.org/content/10.1...

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Apr 28

Some of the ribosomes purified using RAPPL and Cryo-EM structures solved in last couple of months (1/6). Bacterial #1

www.biorxiv.org/content/10.1...

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Apr 18

This was a fun collaboration with Maxim Arttyomov lab on how itaconate inhibits the active site of a peroxiredoxin enzyme. Thanks Maxim for including us in this.

www.nature.com/articles/s42...

Itaconate modulates immune responses via inhibition of peroxiredoxin 5 - Nature Metabolism

Itaconate is shown to non-covalently inhibit the antioxidant enzyme peroxiredoxin 5 in macrophages, thereby modulating the production of mitochondrial peroxide and enhancing the type I interferon prod...

www.nature.com

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Apr 14

Ready for the next RNA session in @asbmb.bsky.social meeting. We start soon...

3 8

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Mar 28

Ribosome data collected from a new and precious sample of 10,000,000 cells from a strange organism. All done using RAPPL, more soon...
www.biorxiv.org/content/10.1...

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Mar 23

My suggestion to everyone is to keep some of your most valuable cell lines and back-ups in your collaborators freezers or at least in different buildings or towns.

1 2

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Mar 23

I should point out that this was a valuable collection of mutant cell lines as well as CRISPR/Cas9 engineered lines with endogenously tagged-RBPs, translation factors, ribosomal proteins and other proteins.

1 1

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Mar 23

3 years after terrible loss (two -80C freezers and all back-ups) of almost all of our collection of regular and mutant human, Drosophila, E. Coli and Plasmodium cells, we are still not finished with insurance.

1 1