David Monchaud
@dmonchaud.bsky.social
🥖😬👨🎨 (France) - 🍯🍷🌧️ (Dijon) - 🧬🔬🧪 (CNRS)
Chemical biology/genetics. Occasional fiction writer in the grant-proposal genre.
Trying to understand why and how DNA and RNA fold into ωєιя∂ℓу ѕнαρє∂ structures.
https://sites.google.com/site/monchaudchembiolab/
Chemical biology/genetics. Occasional fiction writer in the grant-proposal genre.
Trying to understand why and how DNA and RNA fold into ωєιя∂ℓу ѕнαρє∂ structures.
https://sites.google.com/site/monchaudchembiolab/
Biocatalysts made of DNA, and G-quadruplex #G4 DNA in particular, have found a myriad of applications. But is there a real-life application reported so far?
Thrilled to report this long-awaited example with the remediation of industrial wastewater!
In @academic.oup.com
doi.org/10.1093/nsr/...
Thrilled to report this long-awaited example with the remediation of industrial wastewater!
In @academic.oup.com
doi.org/10.1093/nsr/...
February 2, 2026 at 10:19 AM
Biocatalysts made of DNA, and G-quadruplex #G4 DNA in particular, have found a myriad of applications. But is there a real-life application reported so far?
Thrilled to report this long-awaited example with the remediation of industrial wastewater!
In @academic.oup.com
doi.org/10.1093/nsr/...
Thrilled to report this long-awaited example with the remediation of industrial wastewater!
In @academic.oup.com
doi.org/10.1093/nsr/...
FYI: the molecular helicase PhpC we developped to unfold G-quadruplex #G4 DNA and RNA both in vitro (see: shorturl.at/Ep8Il) and in human cells (e.g., shorturl.at/ue7rV, shorturl.at/zsheP & shorturl.at/MfUKW) is now commercially available at Idylle @idylle-labs.bsky.social
👉 shorturl.at/efE5l
👉 shorturl.at/efE5l
January 30, 2026 at 12:09 PM
FYI: the molecular helicase PhpC we developped to unfold G-quadruplex #G4 DNA and RNA both in vitro (see: shorturl.at/Ep8Il) and in human cells (e.g., shorturl.at/ue7rV, shorturl.at/zsheP & shorturl.at/MfUKW) is now commercially available at Idylle @idylle-labs.bsky.social
👉 shorturl.at/efE5l
👉 shorturl.at/efE5l
Happy to be one of these guys going down the White Dune before swimming 10k across the Dakhla bay.
4 days, 4 stages, 4 adventures.
Thank you Morocco Swim Trek 🙏
👉 moroccoswimtrek.com
4 days, 4 stages, 4 adventures.
Thank you Morocco Swim Trek 🙏
👉 moroccoswimtrek.com
December 16, 2025 at 10:11 AM
Happy to be one of these guys going down the White Dune before swimming 10k across the Dakhla bay.
4 days, 4 stages, 4 adventures.
Thank you Morocco Swim Trek 🙏
👉 moroccoswimtrek.com
4 days, 4 stages, 4 adventures.
Thank you Morocco Swim Trek 🙏
👉 moroccoswimtrek.com
How to recapitulate in vitro what happens in cells? Not easy!
We investigated how guanine (G)-rich sequences interact with one another to decipher G4-associated gene expression regulation
With Nanjing U & @polytechniqueparis.bsky.social
@cnrs.fr
In @narjournal.bsky.social: doi.org/10.1093/nar/...
We investigated how guanine (G)-rich sequences interact with one another to decipher G4-associated gene expression regulation
With Nanjing U & @polytechniqueparis.bsky.social
@cnrs.fr
In @narjournal.bsky.social: doi.org/10.1093/nar/...
December 8, 2025 at 10:00 AM
How to recapitulate in vitro what happens in cells? Not easy!
We investigated how guanine (G)-rich sequences interact with one another to decipher G4-associated gene expression regulation
With Nanjing U & @polytechniqueparis.bsky.social
@cnrs.fr
In @narjournal.bsky.social: doi.org/10.1093/nar/...
We investigated how guanine (G)-rich sequences interact with one another to decipher G4-associated gene expression regulation
With Nanjing U & @polytechniqueparis.bsky.social
@cnrs.fr
In @narjournal.bsky.social: doi.org/10.1093/nar/...
A huge thank you to Jean-Louis Mergny, Jérome and Pascale @polytechniqueparis.bsky.social for organizing the "G-quadruplex (G4) made in France": two days filled with diverse and fascinating exchanges on the many facets of #G4 research!
November 29, 2025 at 10:06 PM
A huge thank you to Jean-Louis Mergny, Jérome and Pascale @polytechniqueparis.bsky.social for organizing the "G-quadruplex (G4) made in France": two days filled with diverse and fascinating exchanges on the many facets of #G4 research!
Super proud of my team! They have simplified the synthesis of TASQs, enabling easier & faster access to these biomimetic G-quadruplex (G4) ligands used to image and identify cellular G4s.
The TASQs story: doi.org/10.1021/acs....
This new article @chemistryeurope.bsky.social: doi.org/10.1002/chem...
The TASQs story: doi.org/10.1021/acs....
This new article @chemistryeurope.bsky.social: doi.org/10.1002/chem...
November 24, 2025 at 9:28 AM
Super proud of my team! They have simplified the synthesis of TASQs, enabling easier & faster access to these biomimetic G-quadruplex (G4) ligands used to image and identify cellular G4s.
The TASQs story: doi.org/10.1021/acs....
This new article @chemistryeurope.bsky.social: doi.org/10.1002/chem...
The TASQs story: doi.org/10.1021/acs....
This new article @chemistryeurope.bsky.social: doi.org/10.1002/chem...
A novel biotechnological application for G4s, used for controlling the activity of a CRISPR-Cas12a device used for diagnosing human viral infection (HPV) in a spatio-temporal manner
Now in Anal. Chem. @pubs.acs.org
With Nanjing U. & @polytechniqueparis.bsky.social
@cnrs.fr
doi.org/10.1021/acs....
Now in Anal. Chem. @pubs.acs.org
With Nanjing U. & @polytechniqueparis.bsky.social
@cnrs.fr
doi.org/10.1021/acs....
November 3, 2025 at 1:17 PM
A novel biotechnological application for G4s, used for controlling the activity of a CRISPR-Cas12a device used for diagnosing human viral infection (HPV) in a spatio-temporal manner
Now in Anal. Chem. @pubs.acs.org
With Nanjing U. & @polytechniqueparis.bsky.social
@cnrs.fr
doi.org/10.1021/acs....
Now in Anal. Chem. @pubs.acs.org
With Nanjing U. & @polytechniqueparis.bsky.social
@cnrs.fr
doi.org/10.1021/acs....
The photoMultiTASQ is a new molecular tool to investigate G-quadruplex #G4 biology, notably for identifying G4 binding proteins by Chem-CLIP (chemical cross-linking and isolation by pull-down)
In ACS Bio & Med Chem Au: doi.org/10.1021/acsb...
With @iphc-strasbourg.bsky.social (FR) & WIS Rehovot (IS)
In ACS Bio & Med Chem Au: doi.org/10.1021/acsb...
With @iphc-strasbourg.bsky.social (FR) & WIS Rehovot (IS)
November 3, 2025 at 10:13 AM
The photoMultiTASQ is a new molecular tool to investigate G-quadruplex #G4 biology, notably for identifying G4 binding proteins by Chem-CLIP (chemical cross-linking and isolation by pull-down)
In ACS Bio & Med Chem Au: doi.org/10.1021/acsb...
With @iphc-strasbourg.bsky.social (FR) & WIS Rehovot (IS)
In ACS Bio & Med Chem Au: doi.org/10.1021/acsb...
With @iphc-strasbourg.bsky.social (FR) & WIS Rehovot (IS)
Stimulating scientific days #ChemBioParis2025.
Super great to hear Shankar Balasubramanian speaking about G-quadruplex, Matthew Disney about ChemCLIP and Dan Nomura about MYC druggability, among many others
Kudos to @borisvauzeilles.bsky.social & the team for the organization chembioparis2025.com
Super great to hear Shankar Balasubramanian speaking about G-quadruplex, Matthew Disney about ChemCLIP and Dan Nomura about MYC druggability, among many others
Kudos to @borisvauzeilles.bsky.social & the team for the organization chembioparis2025.com
October 9, 2025 at 7:05 AM
Stimulating scientific days #ChemBioParis2025.
Super great to hear Shankar Balasubramanian speaking about G-quadruplex, Matthew Disney about ChemCLIP and Dan Nomura about MYC druggability, among many others
Kudos to @borisvauzeilles.bsky.social & the team for the organization chembioparis2025.com
Super great to hear Shankar Balasubramanian speaking about G-quadruplex, Matthew Disney about ChemCLIP and Dan Nomura about MYC druggability, among many others
Kudos to @borisvauzeilles.bsky.social & the team for the organization chembioparis2025.com
Honored to have been interviewed by Pour La Science, a wide-audience scientific magazine, to discuss the results from @simonelsasser.bsky.social / @puckknipscheer.bsky.social published in @science.org about how DNA repair proteins mold G-quadruplex #G4
👉 tinyurl.com/3k6pxu6d
(sorry, in French only)
👉 tinyurl.com/3k6pxu6d
(sorry, in French only)
August 28, 2025 at 6:47 AM
Honored to have been interviewed by Pour La Science, a wide-audience scientific magazine, to discuss the results from @simonelsasser.bsky.social / @puckknipscheer.bsky.social published in @science.org about how DNA repair proteins mold G-quadruplex #G4
👉 tinyurl.com/3k6pxu6d
(sorry, in French only)
👉 tinyurl.com/3k6pxu6d
(sorry, in French only)
Happy to describe a novel strategy to detect pollutants in food with a super high sensitivity, using G-quadruplex #G4 based biosensing devices.
A collaboration with the University of Nanjing (CN) and Polytechnique Palaiseau (FR)
Now in Anal. Chem. (@pubs.acs.org): doi.org/10.1021/acs....
A collaboration with the University of Nanjing (CN) and Polytechnique Palaiseau (FR)
Now in Anal. Chem. (@pubs.acs.org): doi.org/10.1021/acs....
August 27, 2025 at 7:13 AM
Happy to describe a novel strategy to detect pollutants in food with a super high sensitivity, using G-quadruplex #G4 based biosensing devices.
A collaboration with the University of Nanjing (CN) and Polytechnique Palaiseau (FR)
Now in Anal. Chem. (@pubs.acs.org): doi.org/10.1021/acs....
A collaboration with the University of Nanjing (CN) and Polytechnique Palaiseau (FR)
Now in Anal. Chem. (@pubs.acs.org): doi.org/10.1021/acs....
Happy to describe a novel strategy to combat colorectal cancer by pharmacologically modulating G-quadruplex #G4 RNA found in dysregulated lncRNAs, using the molecular helicase PhpC.
A collaboration with ITTGN (India) and supported by @embo.org fellowships
Now in BMC Biol.: doi.org/10.1186/s129...
A collaboration with ITTGN (India) and supported by @embo.org fellowships
Now in BMC Biol.: doi.org/10.1186/s129...
August 26, 2025 at 6:41 AM
Happy to describe a novel strategy to combat colorectal cancer by pharmacologically modulating G-quadruplex #G4 RNA found in dysregulated lncRNAs, using the molecular helicase PhpC.
A collaboration with ITTGN (India) and supported by @embo.org fellowships
Now in BMC Biol.: doi.org/10.1186/s129...
A collaboration with ITTGN (India) and supported by @embo.org fellowships
Now in BMC Biol.: doi.org/10.1186/s129...
A novel demonstration of the G-quadruplex #G4 unfolding properties of PhpC, a quite unique prototype of G4 unfolder (or molecular helicase) we developed in the lab
In collaboration with C. Cruz @ubeirainterior.bsky.social and R.H.E. Huson @westernu.bsky.social
👉 doi.org/10.1016/j.ij...
In collaboration with C. Cruz @ubeirainterior.bsky.social and R.H.E. Huson @westernu.bsky.social
👉 doi.org/10.1016/j.ij...
June 20, 2025 at 11:50 AM
A novel demonstration of the G-quadruplex #G4 unfolding properties of PhpC, a quite unique prototype of G4 unfolder (or molecular helicase) we developed in the lab
In collaboration with C. Cruz @ubeirainterior.bsky.social and R.H.E. Huson @westernu.bsky.social
👉 doi.org/10.1016/j.ij...
In collaboration with C. Cruz @ubeirainterior.bsky.social and R.H.E. Huson @westernu.bsky.social
👉 doi.org/10.1016/j.ij...
The best of the best!
The core of our community on #DNA #RNA junctions during the first meeting #IMAJ1 including @biometalusc.bsky.social, @sebastien-britton.bsky.social, @christinecardin.bsky.social, @granzhan.bsky.social, Jean-Louis, Mark and many others
Thank you again for your participation!
The core of our community on #DNA #RNA junctions during the first meeting #IMAJ1 including @biometalusc.bsky.social, @sebastien-britton.bsky.social, @christinecardin.bsky.social, @granzhan.bsky.social, Jean-Louis, Mark and many others
Thank you again for your participation!
May 20, 2025 at 8:33 AM
The best of the best!
The core of our community on #DNA #RNA junctions during the first meeting #IMAJ1 including @biometalusc.bsky.social, @sebastien-britton.bsky.social, @christinecardin.bsky.social, @granzhan.bsky.social, Jean-Louis, Mark and many others
Thank you again for your participation!
The core of our community on #DNA #RNA junctions during the first meeting #IMAJ1 including @biometalusc.bsky.social, @sebastien-britton.bsky.social, @christinecardin.bsky.social, @granzhan.bsky.social, Jean-Louis, Mark and many others
Thank you again for your participation!
It was an absolute thrill and a real pleasure to organize the first meeting on #DNA #RNA junctions in Paris.
Fantastic talks, lively discussions—and some excellent wine too! 🍷😁
A very promising beginning for this new community
Stay tuned—we’ll be back next year!
#IMAJ1 #CNRSchimie @cnrs.fr
Fantastic talks, lively discussions—and some excellent wine too! 🍷😁
A very promising beginning for this new community
Stay tuned—we’ll be back next year!
#IMAJ1 #CNRSchimie @cnrs.fr
May 19, 2025 at 2:34 PM
It was an absolute thrill and a real pleasure to organize the first meeting on #DNA #RNA junctions in Paris.
Fantastic talks, lively discussions—and some excellent wine too! 🍷😁
A very promising beginning for this new community
Stay tuned—we’ll be back next year!
#IMAJ1 #CNRSchimie @cnrs.fr
Fantastic talks, lively discussions—and some excellent wine too! 🍷😁
A very promising beginning for this new community
Stay tuned—we’ll be back next year!
#IMAJ1 #CNRSchimie @cnrs.fr
We're thrilled to have contributed to this @naturecomms.bsky.social paper on the role of G-quadruplex #G4 in mitochondrial RNA
G4s can be targeted with ligands to inhibit mitochondrial translation and eventually functions, which jeopardizes cancer cells fate
This is huge!
👉 doi.org/10.1038/s414...
G4s can be targeted with ligands to inhibit mitochondrial translation and eventually functions, which jeopardizes cancer cells fate
This is huge!
👉 doi.org/10.1038/s414...
April 7, 2025 at 1:59 PM
We're thrilled to have contributed to this @naturecomms.bsky.social paper on the role of G-quadruplex #G4 in mitochondrial RNA
G4s can be targeted with ligands to inhibit mitochondrial translation and eventually functions, which jeopardizes cancer cells fate
This is huge!
👉 doi.org/10.1038/s414...
G4s can be targeted with ligands to inhibit mitochondrial translation and eventually functions, which jeopardizes cancer cells fate
This is huge!
👉 doi.org/10.1038/s414...
Welcome to BlueSky @jamchemsoc.bsky.social !
Happy to celebrate your arrival amongst us with this new article (doi.org/10.1021/jacs...), in which we report on CoRP-seq, a technique for mapping RNA G-quadruplex #G4 transcriptome-wide in a fast, cheap and simple manner
#chembio #AcademicSky #SciSky
Happy to celebrate your arrival amongst us with this new article (doi.org/10.1021/jacs...), in which we report on CoRP-seq, a technique for mapping RNA G-quadruplex #G4 transcriptome-wide in a fast, cheap and simple manner
#chembio #AcademicSky #SciSky
March 11, 2025 at 10:36 AM
Welcome to BlueSky @jamchemsoc.bsky.social !
Happy to celebrate your arrival amongst us with this new article (doi.org/10.1021/jacs...), in which we report on CoRP-seq, a technique for mapping RNA G-quadruplex #G4 transcriptome-wide in a fast, cheap and simple manner
#chembio #AcademicSky #SciSky
Happy to celebrate your arrival amongst us with this new article (doi.org/10.1021/jacs...), in which we report on CoRP-seq, a technique for mapping RNA G-quadruplex #G4 transcriptome-wide in a fast, cheap and simple manner
#chembio #AcademicSky #SciSky
A fully detailed protocol to visualize G-quadruplex #G4 DNA/RNA in human cells using clickable G4 ligands (in situ click imaging) now in @bio-protocol.bsky.social
Interested?? All you need is:
- the clickable ligand: www.sigmaaldrich.com/FR/en/produc...
- and the protocol: doi.org/10.21769/Bio...
Interested?? All you need is:
- the clickable ligand: www.sigmaaldrich.com/FR/en/produc...
- and the protocol: doi.org/10.21769/Bio...
January 22, 2025 at 7:56 AM
A fully detailed protocol to visualize G-quadruplex #G4 DNA/RNA in human cells using clickable G4 ligands (in situ click imaging) now in @bio-protocol.bsky.social
Interested?? All you need is:
- the clickable ligand: www.sigmaaldrich.com/FR/en/produc...
- and the protocol: doi.org/10.21769/Bio...
Interested?? All you need is:
- the clickable ligand: www.sigmaaldrich.com/FR/en/produc...
- and the protocol: doi.org/10.21769/Bio...
Quite happy to see this out in @chemistryeurope.bsky.social (with ENS Paris FR, Szeged University HU, UTC Prague CZ)
We report here on molecular tools used to detect G-quadruplex #G4 DNA/RNA in vitro, and on the mechanism underlying their unique photophysical properties.
👉 doi.org/10.1002/cmdc...
We report here on molecular tools used to detect G-quadruplex #G4 DNA/RNA in vitro, and on the mechanism underlying their unique photophysical properties.
👉 doi.org/10.1002/cmdc...
January 15, 2025 at 1:14 PM
Quite happy to see this out in @chemistryeurope.bsky.social (with ENS Paris FR, Szeged University HU, UTC Prague CZ)
We report here on molecular tools used to detect G-quadruplex #G4 DNA/RNA in vitro, and on the mechanism underlying their unique photophysical properties.
👉 doi.org/10.1002/cmdc...
We report here on molecular tools used to detect G-quadruplex #G4 DNA/RNA in vitro, and on the mechanism underlying their unique photophysical properties.
👉 doi.org/10.1002/cmdc...
A fully detailed method (40+ steps) to isolate/identify RNA G-quadruplex #G4 in human cells using G4-RNA precipitation (G4RP) protocol
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
December 11, 2024 at 9:14 AM
A fully detailed method (40+ steps) to isolate/identify RNA G-quadruplex #G4 in human cells using G4-RNA precipitation (G4RP) protocol
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
One of the ones I am most proud of.
In this article, we abided by the very definition of chemical biology #ChemBio to decipher the role that DNA/RNA G-quadruplex #G4 plays, and the effects that the G4 ligands have, in human cells.
👉https://dx.doi.org/10.1016/j.jbc.2024.108040
@cnrs.bsky.social
In this article, we abided by the very definition of chemical biology #ChemBio to decipher the role that DNA/RNA G-quadruplex #G4 plays, and the effects that the G4 ligands have, in human cells.
👉https://dx.doi.org/10.1016/j.jbc.2024.108040
@cnrs.bsky.social
December 3, 2024 at 10:33 AM
One of the ones I am most proud of.
In this article, we abided by the very definition of chemical biology #ChemBio to decipher the role that DNA/RNA G-quadruplex #G4 plays, and the effects that the G4 ligands have, in human cells.
👉https://dx.doi.org/10.1016/j.jbc.2024.108040
@cnrs.bsky.social
In this article, we abided by the very definition of chemical biology #ChemBio to decipher the role that DNA/RNA G-quadruplex #G4 plays, and the effects that the G4 ligands have, in human cells.
👉https://dx.doi.org/10.1016/j.jbc.2024.108040
@cnrs.bsky.social
My (little) contribution to make the field of G-quadruplex #G4 ligands accessible to all..
.. and to show how pivotal ligands have been as #ChemBio tools to decipher G4 biology.
A personal view on the contribution of Pr. Stephen Neidle in a Sp. Issue honoring S. Neidle 😉
👉 doi.org/10.1007/s000...
.. and to show how pivotal ligands have been as #ChemBio tools to decipher G4 biology.
A personal view on the contribution of Pr. Stephen Neidle in a Sp. Issue honoring S. Neidle 😉
👉 doi.org/10.1007/s000...
November 27, 2024 at 9:40 AM
My (little) contribution to make the field of G-quadruplex #G4 ligands accessible to all..
.. and to show how pivotal ligands have been as #ChemBio tools to decipher G4 biology.
A personal view on the contribution of Pr. Stephen Neidle in a Sp. Issue honoring S. Neidle 😉
👉 doi.org/10.1007/s000...
.. and to show how pivotal ligands have been as #ChemBio tools to decipher G4 biology.
A personal view on the contribution of Pr. Stephen Neidle in a Sp. Issue honoring S. Neidle 😉
👉 doi.org/10.1007/s000...
Kane is an artist, his work deserves to be highlighted ;-) this one is also one of his masterpieces
November 17, 2024 at 9:11 AM
Kane is an artist, his work deserves to be highlighted ;-) this one is also one of his masterpieces
Hi DNA/RNA folks!
With @granzhan.bsky.social @sebastien-britton.bsky.social @glowsticks.bsky.social and others we are launching an International Research Network (IRN) on nucleic acid junctions #3WJ - Thanks @cnrs.bsky.social Chimie!
1st meeting next year (May 25) in Paris
Contact me if interested
With @granzhan.bsky.social @sebastien-britton.bsky.social @glowsticks.bsky.social and others we are launching an International Research Network (IRN) on nucleic acid junctions #3WJ - Thanks @cnrs.bsky.social Chimie!
1st meeting next year (May 25) in Paris
Contact me if interested
November 14, 2024 at 10:39 AM
Hi DNA/RNA folks!
With @granzhan.bsky.social @sebastien-britton.bsky.social @glowsticks.bsky.social and others we are launching an International Research Network (IRN) on nucleic acid junctions #3WJ - Thanks @cnrs.bsky.social Chimie!
1st meeting next year (May 25) in Paris
Contact me if interested
With @granzhan.bsky.social @sebastien-britton.bsky.social @glowsticks.bsky.social and others we are launching an International Research Network (IRN) on nucleic acid junctions #3WJ - Thanks @cnrs.bsky.social Chimie!
1st meeting next year (May 25) in Paris
Contact me if interested
(4/4) With my buddies @sebastien-britton.bsky.social and @granzhan.bsky.social we are currently designing, synthesizing and using small molecules aimed at interacting with alternative DNA and RNA structures (mostly three-way junctions #3WJ and G-quadruplex #G4) to decipher their cellular biology
November 13, 2024 at 7:31 AM
(4/4) With my buddies @sebastien-britton.bsky.social and @granzhan.bsky.social we are currently designing, synthesizing and using small molecules aimed at interacting with alternative DNA and RNA structures (mostly three-way junctions #3WJ and G-quadruplex #G4) to decipher their cellular biology