Mehdi Bouhaddou
@doctorbou.bsky.social
The Molecular Thinking Lab @UCLA
We apply systems biology to study the biochemical logic of post-translational mods and protein-protein interactions.
🦠 Virology, 🪸coral, and 🧫 cancer
🎰 Mass spec and 💾 bioinformatics
🌊 50% wet, 🌵50% dry
🏳️🌈 Welcome to all
We apply systems biology to study the biochemical logic of post-translational mods and protein-protein interactions.
🦠 Virology, 🪸coral, and 🧫 cancer
🎰 Mass spec and 💾 bioinformatics
🌊 50% wet, 🌵50% dry
🏳️🌈 Welcome to all
Thrilled to share the first major preprint from the lab. Viruses are classically viewed as targets of host sensing. Do viruses also sense and respond to the host? We propose viruses may act as “biosensors” of the host signaling state. A thread👇🏾 www.biorxiv.org/content/10.1...
Global Landscape of Human Kinase Motifs in Viral Proteomes
Viruses are classically viewed as targets of host sensing, yet whether they also sense and respond to host cues remains largely unexplored. We propose that host-driven post-translational modification ...
www.biorxiv.org
December 31, 2025 at 4:27 PM
Thrilled to share the first major preprint from the lab. Viruses are classically viewed as targets of host sensing. Do viruses also sense and respond to the host? We propose viruses may act as “biosensors” of the host signaling state. A thread👇🏾 www.biorxiv.org/content/10.1...
Happy holidays from the Bouhaddou Lab!
December 13, 2025 at 6:20 PM
Happy holidays from the Bouhaddou Lab!
Reposted by Mehdi Bouhaddou
🔬New Preprint Alert 🔬 How is AMPK regulated by oxidative stress? We use functional imaging to uncover spatial regulation of AMPK activity during oxidative stress by LKB1 & CaMKK2. Combining imaging with proteomics & metabolomics, we find AMPK works to promote the cellular redox response.
Spatial regulation of AMPK activity under oxidative stress requires LKB1 https://www.biorxiv.org/content/10.1101/2025.11.17.688926v1
November 18, 2025 at 3:56 AM
🔬New Preprint Alert 🔬 How is AMPK regulated by oxidative stress? We use functional imaging to uncover spatial regulation of AMPK activity during oxidative stress by LKB1 & CaMKK2. Combining imaging with proteomics & metabolomics, we find AMPK works to promote the cellular redox response.
Reposted by Mehdi Bouhaddou
Here's the letter that NSF sent UCLA last week about cutting its research funding
NSF says UCLA is doing affirmative action by asking applicants' their zip codes, family income and what HS they went to, and that they can discuss race in personal statements
storage.courtlistener.com/recap/gov.us...
NSF says UCLA is doing affirmative action by asking applicants' their zip codes, family income and what HS they went to, and that they can discuss race in personal statements
storage.courtlistener.com/recap/gov.us...
August 4, 2025 at 11:48 PM
Here's the letter that NSF sent UCLA last week about cutting its research funding
NSF says UCLA is doing affirmative action by asking applicants' their zip codes, family income and what HS they went to, and that they can discuss race in personal statements
storage.courtlistener.com/recap/gov.us...
NSF says UCLA is doing affirmative action by asking applicants' their zip codes, family income and what HS they went to, and that they can discuss race in personal statements
storage.courtlistener.com/recap/gov.us...
If you are interested to learn about our work studying firefighter health in LA! We study how exposure to toxic chemicals alters phosphorylation signaling in lung cells to drive cancer. www.uclahealth.org/news/article...
Firefighters have a higher risk of cancer – but why?
UCLA researchers are working with the Los Angeles County fire department to test firefighting gear as a possible source of risk.
www.uclahealth.org
April 3, 2025 at 12:43 PM
If you are interested to learn about our work studying firefighter health in LA! We study how exposure to toxic chemicals alters phosphorylation signaling in lung cells to drive cancer. www.uclahealth.org/news/article...