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Reposted by David Pla Martin

Biomedical Picture of the Day BPoD @bpodaily.bsky.social · May 8

Protein complex, the retromer, promotes recycling/disposal of damaged mitochondrial DNA

📷 Parisa Kakanj & Mari Bonse et al
@dplamartin.bsky.social
lab University of Cologne, Cologne, Germany in
@science.org Science Advances

➡️ bpod.org.uk/archive/2025... with
@rooph.bsky.social

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David Pla Martin @dplamartin.bsky.social · Apr 29

Cecad is always at the edge of innovation.

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Reposted by David Pla Martin

Christian Frezza @frezzalab.bsky.social · Apr 9

Small molecules restore mutant mitochondrial DNA polymerase activity
www.nature.com/articles/s41...

Small molecules restore mutant mitochondrial DNA polymerase activity - Nature

An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.

www.nature.com

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David Pla Martin @dplamartin.bsky.social · Apr 5

Thanks Alessandro!

David Pla Martin @dplamartin.bsky.social · Apr 5

Thanks Christian!

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David Pla Martin @dplamartin.bsky.social · Apr 5

Thanks Sofia!

Reposted by David Pla Martin

Sofia Ahola @sofiaahola.bsky.social · Apr 5

What a lovely paper from @dplamartin.bsky.social and his team! Mechanistic insight to mtDNA turnover at the lysosomes. 📬

David Pla Martin @dplamartin.bsky.social · Apr 4

Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵

www.science.org/doi/10.1126/...

Retromer promotes the lysosomal turnover of mtDNA

Lysosomal uptake of mtDNA controls mitochondrial quality.

www.science.org

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David Pla Martin @dplamartin.bsky.social · Apr 5

www.hhu.de/en/news-arti... @hhu.de

Medicine: Publication in Science Advances

Damage to the mitochondria, the “power plants” of the cells, contributes to many diseases. Researchers from Heinrich Heine University Düsseldorf (HHU) and the University of Cologne led by HHU professo...

www.hhu.de

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David Pla Martin @dplamartin.bsky.social · Apr 4

WTH… is VPS35 the next candidate to fight mitochondrial dysfunction? I just leave it here…

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David Pla Martin @dplamartin.bsky.social · Apr 4

Not only we recover mtDNA damage! Look all these transcripts!

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David Pla Martin @dplamartin.bsky.social · Apr 4

We then used Drosophila and expressed VPS35…. 💥 💥 🤯

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David Pla Martin @dplamartin.bsky.social · Apr 4

Ok! But let’s be serious… we noticed that overexpression of the Retromer increased mtDNA release… could we use this to clean up mtDNA damage?

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David Pla Martin @dplamartin.bsky.social · Apr 4

Not only that! Whenever mtDNA is released, look who’s there?! A lysosome

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David Pla Martin @dplamartin.bsky.social · Apr 4

What then? We found that the leak gets inhibited upon inhibition of BAX1 but not VDAC1

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David Pla Martin @dplamartin.bsky.social · Apr 4

Surprise! No, mtDNA leaks independent from MDVs

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David Pla Martin @dplamartin.bsky.social · Apr 4

What about the mtDNA? Is it also release through MDVs?

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David Pla Martin @dplamartin.bsky.social · Apr 4

We took a deep look at the Retromer! This guy was always around! We found that mtDNA stress triggers the formation of MDVs, but wait… they were lysosomal dependent… interesting…

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David Pla Martin @dplamartin.bsky.social · Apr 4

Who was there? Vesicle proteins! Lysosomes! Mitochondria matrix proteins! How?

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David Pla Martin @dplamartin.bsky.social · Apr 4

We started with SplitTurboID between mitochondria and endosomes to find out the proximity proteome upon mtDNA stress…

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David Pla Martin @dplamartin.bsky.social · Apr 4

Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵

www.science.org/doi/10.1126/...

Retromer promotes the lysosomal turnover of mtDNA

Lysosomal uptake of mtDNA controls mitochondrial quality.

www.science.org

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David Pla Martin @dplamartin.bsky.social · Apr 4

Thanks Ryan!

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David Pla Martin @dplamartin.bsky.social · Apr 4

Are u tired of reading about tariffs? Then take a look to our last work! @science.org

www.science.org/doi/10.1126/...

Retromer promotes the lysosomal turnover of mtDNA

Lysosomal uptake of mtDNA controls mitochondrial quality.

www.science.org

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David Pla Martin @dplamartin.bsky.social · Apr 3

Tomorrow will be a good day! I can’t wait to show you what we have…

David Pla Martin @dplamartin.bsky.social · Apr 3

A novel pathomechanism connected to mtDNA-mediated inflammation for CMT2A
www.life-science-alliance.org/content/8/6/...

The MFN2 Q367H variant reveals a novel pathomechanism connected to mtDNA-mediated inflammation

Pathogenic variants in the mitochondrial protein MFN2 are typically associated with a peripheral neuropathy phenotype, but can also cause a variety of additional pathologies including myopathy. Here, ...

www.life-science-alliance.org

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David Pla Martin @dplamartin.bsky.social · Apr 3

Being a PI is hard, we have to deal with one rejection after another, hours of work amounting to nothing because someone thinks our ideas aren’t cool enough. But then, suddenly, you get a yes! And life shines again. Thanks, @dfg.de , for your support!

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