Dr. Foxpaws Fauxpas M.D.
@dr-foxpaws-fauxpas.bsky.social
Clinical Oncologist, perpetual student, quizzer & digital artist.
Interests: GI, Gynec, Breast, Lung, GU, Lymphomas, CNS & palliative medicine.
Building towards a better quality of life for all patients 🐳
Alumnus of JIPMER, Pondicherry, India.
Interests: GI, Gynec, Breast, Lung, GU, Lymphomas, CNS & palliative medicine.
Building towards a better quality of life for all patients 🐳
Alumnus of JIPMER, Pondicherry, India.
Reposted by Dr. Foxpaws Fauxpas M.D.
My take on the #Top5 🔑 studies presented at #SABCS24 for #VuMedi #bcsm #breastcancer @osucccjames.bsky.social @osuwexmed.bsky.social @sabcs.bsky.social
SABCS 2024 Summary: Key Updates From the EMBER-3, PATINA, TAILORx, INSEMA, and OlympiA Trials in Breast Cancer Management
A video from Margaret Gatti-Mays (as part of 2024 SABCS Annual Meeting Insights Hub), posted on Jan 3, 2025.
www.vumedi.com
January 3, 2025 at 3:28 PM
My take on the #Top5 🔑 studies presented at #SABCS24 for #VuMedi #bcsm #breastcancer @osucccjames.bsky.social @osuwexmed.bsky.social @sabcs.bsky.social
One of the most common unnoticed electrolyte imbalance in cancer patients - Hypomagnesemia!
Do test when indicated by keeping it in your DDx !
Here's a quick run through of causes of ⬇️ Mg in Ca pts - especially keep in mind when using:
💊EGFRibs
💉Platins
💊TKIs
💉Anti HER2
#cancer #oncology #oncsky
Do test when indicated by keeping it in your DDx !
Here's a quick run through of causes of ⬇️ Mg in Ca pts - especially keep in mind when using:
💊EGFRibs
💉Platins
💊TKIs
💉Anti HER2
#cancer #oncology #oncsky
December 31, 2024 at 2:04 PM
Antibiotics at increased risk of clostridium difficile infection
Must know for every clinician!
#basics #pharmacology
Must know for every clinician!
#basics #pharmacology
December 29, 2024 at 2:12 PM
Antibiotics at increased risk of clostridium difficile infection
Must know for every clinician!
#basics #pharmacology
Must know for every clinician!
#basics #pharmacology
Reposted by Dr. Foxpaws Fauxpas M.D.
Revising FLIPI 1 & 2 in follicular lymphomas
Compared with m7 FLIPI - 7 gene Clinicogenetic score - validated in GALLIUM - RCHOP/RCVP
❌ in bendamustine regimens
⚡ EZH2 mutation status
-Bendamustine in EZH2 wild type FL
-CHOP/CVP in EZH2 mutated FL ✅ ⬆️ PFS
#lymsm #lymphoma #oncsky #basics
Compared with m7 FLIPI - 7 gene Clinicogenetic score - validated in GALLIUM - RCHOP/RCVP
❌ in bendamustine regimens
⚡ EZH2 mutation status
-Bendamustine in EZH2 wild type FL
-CHOP/CVP in EZH2 mutated FL ✅ ⬆️ PFS
#lymsm #lymphoma #oncsky #basics
December 28, 2024 at 12:49 PM
Revising FLIPI 1 & 2 in follicular lymphomas
Compared with m7 FLIPI - 7 gene Clinicogenetic score - validated in GALLIUM - RCHOP/RCVP
❌ in bendamustine regimens
⚡ EZH2 mutation status
-Bendamustine in EZH2 wild type FL
-CHOP/CVP in EZH2 mutated FL ✅ ⬆️ PFS
#lymsm #lymphoma #oncsky #basics
Compared with m7 FLIPI - 7 gene Clinicogenetic score - validated in GALLIUM - RCHOP/RCVP
❌ in bendamustine regimens
⚡ EZH2 mutation status
-Bendamustine in EZH2 wild type FL
-CHOP/CVP in EZH2 mutated FL ✅ ⬆️ PFS
#lymsm #lymphoma #oncsky #basics
December 28, 2024 at 12:49 PM
Here's a fan #art i made of my favorite #christmas movie!
What's christmas without an elf, a dwarf and a magic white bearded grandpa?
😄 Merry Christmas everyone!
What's christmas without an elf, a dwarf and a magic white bearded grandpa?
😄 Merry Christmas everyone!
December 25, 2024 at 7:32 AM
Here's a fan #art i made of my favorite #christmas movie!
What's christmas without an elf, a dwarf and a magic white bearded grandpa?
😄 Merry Christmas everyone!
What's christmas without an elf, a dwarf and a magic white bearded grandpa?
😄 Merry Christmas everyone!
4 diagnoses, 4 livers.
1 endless week.
Oncology can be pretty darn humbling.
Currently in a spiral of existentialism and confronting one's own mortality.
1 endless week.
Oncology can be pretty darn humbling.
Currently in a spiral of existentialism and confronting one's own mortality.
December 22, 2024 at 3:22 PM
4 diagnoses, 4 livers.
1 endless week.
Oncology can be pretty darn humbling.
Currently in a spiral of existentialism and confronting one's own mortality.
1 endless week.
Oncology can be pretty darn humbling.
Currently in a spiral of existentialism and confronting one's own mortality.
How do immuno modulatory agents work in #myeloma?
And why does Pomalidomide work even after progression on lenalidomide?
Tumor microenvironment plays a major role in myeloma and pathogenesis.
Ikarus Transcription factor is key.
#cancer #hemesky #blood #oncsky
@nihardesai7.bsky.social
And why does Pomalidomide work even after progression on lenalidomide?
Tumor microenvironment plays a major role in myeloma and pathogenesis.
Ikarus Transcription factor is key.
#cancer #hemesky #blood #oncsky
@nihardesai7.bsky.social
December 21, 2024 at 5:46 PM
ICI induced myocarditis ❤️🔥
🔬 Patho (EMBx) - Dallas Cx
Multifocal inflammatory infiltrates + overt cardiomyocyte loss
⚕️Clinical
cTn - new/significant ⬆️⬆️ from baseline
- with 1 major/2 minor criteria
- Exclude ACS/acute infectious myocarditis
#sabcs24 #cancer #bcsm #oncsky #cardio toxicity
🔬 Patho (EMBx) - Dallas Cx
Multifocal inflammatory infiltrates + overt cardiomyocyte loss
⚕️Clinical
cTn - new/significant ⬆️⬆️ from baseline
- with 1 major/2 minor criteria
- Exclude ACS/acute infectious myocarditis
#sabcs24 #cancer #bcsm #oncsky #cardio toxicity
December 12, 2024 at 5:30 PM
Trials supporting Immunotherapy in operable NSCLC
Slides courtesy of the incredible Dr Katsuaki Maehara @katsuaki-maehara.bsky.social
#LUNG #cancer #lcsm #oncsky
Slides courtesy of the incredible Dr Katsuaki Maehara @katsuaki-maehara.bsky.social
#LUNG #cancer #lcsm #oncsky
December 11, 2024 at 2:25 PM
Trials supporting Immunotherapy in operable NSCLC
Slides courtesy of the incredible Dr Katsuaki Maehara @katsuaki-maehara.bsky.social
#LUNG #cancer #lcsm #oncsky
Slides courtesy of the incredible Dr Katsuaki Maehara @katsuaki-maehara.bsky.social
#LUNG #cancer #lcsm #oncsky
Quiz time!
Which conventional chemotherapy agents of the below cannot cross BBB?
Capecitabine
Platinums
Temozolomide
Doxorubicin
#oncsky #chemotherapy #basics #brain #oncology
Below is an microanatomic depiction of physiological vs pathological BBB at a microscopic level.
Which conventional chemotherapy agents of the below cannot cross BBB?
Capecitabine
Platinums
Temozolomide
Doxorubicin
#oncsky #chemotherapy #basics #brain #oncology
Below is an microanatomic depiction of physiological vs pathological BBB at a microscopic level.
December 10, 2024 at 2:02 PM
Quiz time!
Which conventional chemotherapy agents of the below cannot cross BBB?
Capecitabine
Platinums
Temozolomide
Doxorubicin
#oncsky #chemotherapy #basics #brain #oncology
Below is an microanatomic depiction of physiological vs pathological BBB at a microscopic level.
Which conventional chemotherapy agents of the below cannot cross BBB?
Capecitabine
Platinums
Temozolomide
Doxorubicin
#oncsky #chemotherapy #basics #brain #oncology
Below is an microanatomic depiction of physiological vs pathological BBB at a microscopic level.
LEAP program - Lenva and Pembrolizumab in solid tumors
A comprehensive list of LEAP group trials
A summary of site-wise response rates and PFS
Interesting paper!
#oncology #oncsky #lcsm
www.tandfonline.com/doi/full/10....
A comprehensive list of LEAP group trials
A summary of site-wise response rates and PFS
Interesting paper!
#oncology #oncsky #lcsm
www.tandfonline.com/doi/full/10....
December 7, 2024 at 2:49 PM
LEAP program - Lenva and Pembrolizumab in solid tumors
A comprehensive list of LEAP group trials
A summary of site-wise response rates and PFS
Interesting paper!
#oncology #oncsky #lcsm
www.tandfonline.com/doi/full/10....
A comprehensive list of LEAP group trials
A summary of site-wise response rates and PFS
Interesting paper!
#oncology #oncsky #lcsm
www.tandfonline.com/doi/full/10....
⚡ Doses and indications of lenvatinib - for all FDA approved indications.
Along with dose reduction levels
A quick reckoner
Common Tox:
☢️Diarrhea
☢️Asthenia & mucositis
☢️Proteinuria & HTN
☢️Rash and PPE
#oncsky #chemotherapy #basics #oncology
Along with dose reduction levels
A quick reckoner
Common Tox:
☢️Diarrhea
☢️Asthenia & mucositis
☢️Proteinuria & HTN
☢️Rash and PPE
#oncsky #chemotherapy #basics #oncology
December 7, 2024 at 8:02 AM
⚡ Doses and indications of lenvatinib - for all FDA approved indications.
Along with dose reduction levels
A quick reckoner
Common Tox:
☢️Diarrhea
☢️Asthenia & mucositis
☢️Proteinuria & HTN
☢️Rash and PPE
#oncsky #chemotherapy #basics #oncology
Along with dose reduction levels
A quick reckoner
Common Tox:
☢️Diarrhea
☢️Asthenia & mucositis
☢️Proteinuria & HTN
☢️Rash and PPE
#oncsky #chemotherapy #basics #oncology
December 5, 2024 at 3:28 PM
Opinion: Colostomy free survival would be a very good surrogate marker of QOL for ca rectum.
Especially with so many younger patients these days.
Their HRQOL and sexual QOL will also come into play with locoregional recurrence. Organ preservation should be our next great frontier.
#oncsky #cancer
Especially with so many younger patients these days.
Their HRQOL and sexual QOL will also come into play with locoregional recurrence. Organ preservation should be our next great frontier.
#oncsky #cancer
December 4, 2024 at 2:55 AM
TCGA - Gastric Ca Molecular Classification
👁️ EBV - best outcomes following resection, notably absent in GEJ
❌ GS- Lauren Diffuse-poor outcomes, poor chemoresponse
🧬 CIN - Lauren Intestinal - benefit of adj chemo ⬆️
Snapshot of targeted therapies for Gastric adenoca
#gi #gastro #cancer #oncsky
👁️ EBV - best outcomes following resection, notably absent in GEJ
❌ GS- Lauren Diffuse-poor outcomes, poor chemoresponse
🧬 CIN - Lauren Intestinal - benefit of adj chemo ⬆️
Snapshot of targeted therapies for Gastric adenoca
#gi #gastro #cancer #oncsky
December 2, 2024 at 6:06 PM
👑 RCHOP remains king/queen in limited stage DLBCL.
✅ PET adapted therapy - best for assessing risk groups for recurrence.
✅ Polatuzumab - better for Non GCB subtype and elderly subgroup - at the cost of increased neuropathy
☢️RT if decreased chemo tolerance ⬇️
#lymphoma #oncsky #heme #cancers
✅ PET adapted therapy - best for assessing risk groups for recurrence.
✅ Polatuzumab - better for Non GCB subtype and elderly subgroup - at the cost of increased neuropathy
☢️RT if decreased chemo tolerance ⬇️
#lymphoma #oncsky #heme #cancers
December 1, 2024 at 1:10 AM