David Glass, PhD
@dr-glass.bsky.social
Systems immunologist
Postdoc @ Fred Hutch Cancer Center
Postdoc @ Fred Hutch Cancer Center
Reposted by David Glass, PhD
A study from the lab of @evnewell.bsky.social looks at the immune response to multiple myeloma. It turned out the most interesting thing was what they didn’t find: T cells that had already recognized and tried to fight off tumor cells. Read more: pubmed.ncbi.nlm.nih.gov/40163891/
July 7, 2025 at 4:55 PM
A study from the lab of @evnewell.bsky.social looks at the immune response to multiple myeloma. It turned out the most interesting thing was what they didn’t find: T cells that had already recognized and tried to fight off tumor cells. Read more: pubmed.ncbi.nlm.nih.gov/40163891/
I'm happy to share our new publication exploring T cell responses in patients with newly diagnosed multiple myeloma. Using single-cell multi-omics, we found no evidence of T cell exhaustion nor a productive clonal T cell response, suggesting myeloma uses an alternative immune evasion strategy.
Hallmarks of T-cell exhaustion and antigen experience are absent in multiple myeloma from diagnosis to maintenance therapy
Key PointsEvidence of tumor-specific and/or terminally exhausted CD8+ T cells is absent in a longitudinally analyzed cohort of patients with NDMM.
doi.org
June 30, 2025 at 8:09 PM
I'm happy to share our new publication exploring T cell responses in patients with newly diagnosed multiple myeloma. Using single-cell multi-omics, we found no evidence of T cell exhaustion nor a productive clonal T cell response, suggesting myeloma uses an alternative immune evasion strategy.
I'm presenting my research investigating multi-omic profiles and functional characteristics of human antibody-secreting cells at the Lymphocyte Homeostasis Block Symposium Tuesday at 12:30. If you love high-dimensional analyses, human immunology, and good old-fashioned benchtop experiments, stop by!
May 1, 2025 at 7:22 PM
I'm presenting my research investigating multi-omic profiles and functional characteristics of human antibody-secreting cells at the Lymphocyte Homeostasis Block Symposium Tuesday at 12:30. If you love high-dimensional analyses, human immunology, and good old-fashioned benchtop experiments, stop by!