@drakonhru.bsky.social
Reposted
KJ Muldoon’s name and photo were splashed across newspapers and broadcasts around the world as the first known person to receive a personalized CRISPR-based genome-editing therapy. He’s part of Nature’s 10. 🧪
The baby whose life was saved by the first personalized CRISPR therapy
KJ Muldoon is part of Nature’s 10, a list of people who shaped science in 2025.
go.nature.com
December 27, 2025 at 5:39 PM
KJ Muldoon’s name and photo were splashed across newspapers and broadcasts around the world as the first known person to receive a personalized CRISPR-based genome-editing therapy. He’s part of Nature’s 10. 🧪
Reposted
Details of a 60-year-old male from Germany who achieved sustained HIV remission after a stem cell transplant, the 7th-known case reported, are published in Nature. This individual received cells with just one copy of a mutated gene for a protein required in HIV-1 infection:
#WorldAIDSDay #EndAIDS
#WorldAIDSDay #EndAIDS
Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation - Nature
HIV cure is exceptionally rare, documented in only six cases among the estimated 88 million individuals who have acquired HIV since the epidemic's onset1–6. Successful cures, including the pioneering Berlin patient, are limited to individuals receiving allogeneic stem cell transplants (allo-SCT) for hematological cancers. HIV resistance from stem cell donors with the rare homozygous CCR5 Δ32 mutation was long considered the main mechanism for HIV remission without antiretroviral therapy (ART), but recent reports highlight CCR5-independent mechanisms as important contributors to HIV cure6–8. Here, we provide new evidence for this conceptual shift, reporting exceptionally long, treatment-free HIV remission following allo-SCT with functionally active CCR5. A heterozygous CCR5 wild-type/Δ32 male living with HIV received allo-SCT from an HLA-matched unrelated heterozygous CCR5 wild-type/Δ32 donor as treatment for acute myeloid leukemia. Three years after allo-SCT, the patient discontinued ART. To date, HIV remission has been sustained for over six years with undetectable plasma HIV RNA. Reservoir analysis revealed intact proviral HIV before transplantation, but no replication-competent virus in blood or intestinal tissues after allo-SCT. Declining or absent HIV-specific antibody and T cell responses support the absence of viral activity. High antibody-dependent cellular cytotoxicity (ADCC) activity at the time of transplantation may have contributed to HIV reservoir clearance. These results demonstrate that CCR5Δ32-mediated HIV resistance is not essential for durable remission, underscoring the importance of effective viral reservoir reductions in HIV cure strategies.
spklr.io
December 1, 2025 at 7:13 PM
Details of a 60-year-old male from Germany who achieved sustained HIV remission after a stem cell transplant, the 7th-known case reported, are published in Nature. This individual received cells with just one copy of a mutated gene for a protein required in HIV-1 infection:
#WorldAIDSDay #EndAIDS
#WorldAIDSDay #EndAIDS
奇跡の海
open.spotify.com
November 9, 2025 at 10:47 PM
@michaelastackpole.bsky.social @alexmoukala.bsky.social for amusement www.youtube.com/watch?v=3OrH...
Electric Callboy - TANZNEID (OFFICIAL VIDEO)
YouTube video by Electric Callboy
www.youtube.com
November 8, 2025 at 11:11 PM
When Wolfram Weimer (culture minister) warned that AI companies will flood the book market with their crap and that all those companies are parasitic in nature.....whose is offended Trump adivisors @artofbattletech.bsky.social @michaelastackpole.bsky.social @markhamillofficial.bsky.social
October 15, 2025 at 11:10 PM
When Wolfram Weimer (culture minister) warned that AI companies will flood the book market with their crap and that all those companies are parasitic in nature.....whose is offended Trump adivisors @artofbattletech.bsky.social @michaelastackpole.bsky.social @markhamillofficial.bsky.social
You know the political situation is bad when a completely apolitical big streamer goes apeshit @michaelastackpole.bsky.social @markhamillofficial.bsky.social @realtexaspaul.com @georgetakei.bsky.social www.youtube.com/watch?v=C0Hw...
Brainwashing Situation is Crazy
YouTube video by penguinz0
www.youtube.com
October 12, 2025 at 9:24 PM
You know the political situation is bad when a completely apolitical big streamer goes apeshit @michaelastackpole.bsky.social @markhamillofficial.bsky.social @realtexaspaul.com @georgetakei.bsky.social www.youtube.com/watch?v=C0Hw...
【桜の鬼】KAO=S & 波動會 - live at 和楽器BAR 龍宮~Ryu Guw~
YouTube video by KAO＝S
www.youtube.com
October 4, 2025 at 9:30 PM
For good christmas experience prepare a good Stollen, gingerbread house and hot chocolate....and cozy yourself up and stay in bed @michaelastackpole.bsky.social @markhamillofficial.bsky.social @realtexaspaul.com @georgetakei.bsky.social
a person is holding a loaf of blueberry bread with icing
ALT: a person is holding a loaf of blueberry bread with icing
media.tenor.com
October 1, 2025 at 7:48 PM
For good christmas experience prepare a good Stollen, gingerbread house and hot chocolate....and cozy yourself up and stay in bed @michaelastackpole.bsky.social @markhamillofficial.bsky.social @realtexaspaul.com @georgetakei.bsky.social
Reposted
Dinosaurs promoted open habitats in the Late Cretaceous, and their extinction could have led to a radical reorganization of the landscape and ecosystem structure at the beginning of the Paleogene, according to a study in Communications Earth & Environment. go.nature.com/3InFngj #Paleosky 🧪
September 17, 2025 at 10:42 PM
Dinosaurs promoted open habitats in the Late Cretaceous, and their extinction could have led to a radical reorganization of the landscape and ecosystem structure at the beginning of the Paleogene, according to a study in Communications Earth & Environment. go.nature.com/3InFngj #Paleosky 🧪
Now we need an alternative for discord in the future after Comer targeting discord, steam, twitch and reddit....not sure if he is pissed that discord was a key leading role in Nepal election @georgetakei.bsky.social @realtexaspaul.com @sanders.senate.gov
September 17, 2025 at 9:25 PM
Now we need an alternative for discord in the future after Comer targeting discord, steam, twitch and reddit....not sure if he is pissed that discord was a key leading role in Nepal election @georgetakei.bsky.social @realtexaspaul.com @sanders.senate.gov
@realtexaspaul.com @georgetakei.bsky.social So around 22 sites in USA will closed down by Hyundai....so even less jobs prospektives in the future for US citizens
September 12, 2025 at 4:48 PM
@realtexaspaul.com @georgetakei.bsky.social So around 22 sites in USA will closed down by Hyundai....so even less jobs prospektives in the future for US citizens
Prepared training gear for working out at home
August 19, 2025 at 5:57 PM
Prepared training gear for working out at home
Guess what was the most famous song at main matsuri www.youtube.com/watch?v=miom...
Chicken Attack // Song Voyage // Japan // ft. Takeo Ischi
YouTube video by schmoyoho
www.youtube.com
August 19, 2025 at 1:44 PM
Guess what was the most famous song at main matsuri www.youtube.com/watch?v=miom...
Main Matsuri haul.......was great, saw my friends from japan, had a blast with music, great food......only slight sunburn on knees tho
August 18, 2025 at 6:23 PM
Main Matsuri haul.......was great, saw my friends from japan, had a blast with music, great food......only slight sunburn on knees tho
@mcuban.bsky.social Hey Mark, how about developing an own streaming/video portal......just give it with better technique, cleaner search structure....moderate adds (not like youtube but maybe banner without noises), better reimbursement for creators (maybe give them control which adds they want)
August 10, 2025 at 11:41 PM
@mcuban.bsky.social Hey Mark, how about developing an own streaming/video portal......just give it with better technique, cleaner search structure....moderate adds (not like youtube but maybe banner without noises), better reimbursement for creators (maybe give them control which adds they want)
Tonight i didnt really sleep..just was awake, flooded with regrets..on things i did as a child...its kinda strange the earliest memory that i have was tied with regrets...when i hurt someone, failed to protect, failed to act, failed to speak up...i wish i could render apologies but i have no excuse
July 30, 2025 at 11:17 AM
Tonight i didnt really sleep..just was awake, flooded with regrets..on things i did as a child...its kinda strange the earliest memory that i have was tied with regrets...when i hurt someone, failed to protect, failed to act, failed to speak up...i wish i could render apologies but i have no excuse