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Reposted by Annabelle Singer

Society for Neuroscience @sfn.org · Sep 3

Submissions for late-breaking abstracts are now open!  

Share your most recent and exciting research with a global audience at #SfN25. 

Submit your late-breaking abstract by Wednesday, September 10. 

🔗 vist.ly/45gzc

#neurosky #neuroskyence #academicchatter

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Annabelle Singer @drannabellesinger.bsky.social · Jul 24

and was made possible by collaborations with the labs of Levi Wood and @sloanlab.bsky.social
Preprint is here: www.biorxiv.org/content/10.1...

Sensory neurostimulation promotes stress resilience with frequency-specificity

Chronic stress is a major risk factor for neuropsychiatric disorders, acting via increased neuroinflammation and disrupted synaptic plasticity. While non-invasive visual or audiovisual neurostimulatio...

www.biorxiv.org

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Annabelle Singer @drannabellesinger.bsky.social · Jul 24

This work points towards a promising, non-invasive path for building resilience to stress and stress-related neuropsychiatric disorders. This study was made possible via generous support from the @brightfocus.bsky.social, @alzassociation.bsky.social‬, and the NIH

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Annabelle Singer @drannabellesinger.bsky.social · Jul 24

Tina’s idea turned out to be true, and we were surprised to find that 10Hz sensory stimulation was the most beneficial in males, while 40Hz was the most beneficial in females. This is a fundamentally new approach to mitigate the damaging effects of chronic stress.

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Annabelle Singer @drannabellesinger.bsky.social · Jul 24

Tina’s insight was based putting together separate fields showing, on the one hand that chronic stress causes damage via maladaptive neuroimmune responses and on the other hand that sensory stimulation alters neuroimmune function in unstressed conditions.

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Annabelle Singer @drannabellesinger.bsky.social · Jul 24

Can we experience stress without the damaging effects? Here, we find that non-invasive sensory stimulation at the right frequency induces stress resilience. Tina started this project with a creative idea: can we use sensory stimulation to prevent the damaging effects of chronic stress?

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Annabelle Singer @drannabellesinger.bsky.social · Jul 24

Check out new findings from @TinaFranklin: "Sensory neurostimulation promotes stress resilience with frequency-specificity" on bioRxiv: www.biorxiv.org/content/10.1...

Chronic stress is a major risk factor for neuropsychiatric and neurodegenerative diseases, but for many of us it's unavoidable.

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Reposted by Annabelle Singer

Society for Neuroscience @sfn.org · Jul 14

#SfN25 provides an unparalleled scientific program highlighting emerging science from across the field.

Get a first look at speakers, events, lectures, and more in the Neuroscience 2025 Preliminary Program.

🔗 vist.ly/3xvcw

Drop a comment below to let us know your big three!

#neurosky

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Annabelle Singer @drannabellesinger.bsky.social · Jul 10

and by funding from the CART foundation, the NIH, the NSF, the BrightFocus foundation, and the Alzheimer’s Association. The paper is here: doi.org/10.1063/5.02...

Frequency and duration of sensory flicker control transcriptional profiles in 5xFAD mice

Current clinical trials are investigating gamma frequency sensory stimulation as a potential therapeutic strategy for Alzheimer's disease (AD); yet, we lack a c

doi.org

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Annabelle Singer @drannabellesinger.bsky.social · Jul 10

These insights enable stimulation “tuning” to target specific functions. This work also highlights how flicker stimulation has multiple biological effects and we think such a multipotent therapeutic approach is required for neurodegenerative diseases. This study was made possible by Levi Wood’s lab

Frequency and duration of sensory flicker control transcriptional profiles in 5xFAD mice

Current clinical trials are investigating gamma frequency sensory stimulation as a potential therapeutic strategy for Alzheimer's disease (AD); yet, we lack a c

doi.org

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Annabelle Singer @drannabellesinger.bsky.social · Jul 10

Check out new work by Sara Bitarafan showing that the frequency and duration of audiovisual flicker stimulation are key variables that dictate how flicker affects immune, neuronal, and metabolic genes in the context of Alzheimer’s disease pathology: doi.org/10.1063/5.02....

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Annabelle Singer @drannabellesinger.bsky.social · Jul 9

‪‪@stephmprince.bsky.social‬'s‬ recent paper was included in the Editors’ page “From brain to behaviour”. Check it out here: www.nature.com/collections/...

Editors’ Highlights pages showcase exciting recent papers in an area.

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Annabelle Singer @drannabellesinger.bsky.social · Jun 26

The paper is here: www.nature.com/articles/s41...

New information triggers prospective codes to adapt for flexible navigation - Nature Communications

Neural mechanisms underlying flexible navigation are not fully understood. Here authors reveal how neural circuits dynamically adapt navigational plans in response to new information. Hippocampal circ...

www.nature.com

Annabelle Singer @drannabellesinger.bsky.social · Jun 26

Joshua Stewart explains our recent paper by @stephmprince.bsky.social on how our brains adapt in a dynamic environment to still reach our destination: coe.gatech.edu/news/2025/06... This work was supported by the NIH, NSF, McCamish Foundation, and Packard Foundation

How New Information Triggers the Brain to Navigate Changing Environments

Biomedical engineers show how two brain regions quickly adapt to shift focus from one planned destination to another.

coe.gatech.edu

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Annabelle Singer @drannabellesinger.bsky.social · Jun 13

I can be your sponsor

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Annabelle Singer @drannabellesinger.bsky.social · Jun 6

No but I'd love to know how it goes. 😬

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Annabelle Singer @drannabellesinger.bsky.social · May 31

SFN abstracts are due Wednesday, June 4, at 5 p.m. Eastern Daylight Time.

Society for Neuroscience @sfn.org · May 27

Groundbreaking scientific discoveries don’t happen in isolation.

Michelle Gray, PhD, SfN Program Committee member, shares how you can enhance your research through valuable exchange w/ the global scientific community at #SfN25.

Don't delay, submit your abstract today!

🔗 bit.ly/3G5vEde

#NeuroSky

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Annabelle Singer @drannabellesinger.bsky.social · May 28

Steph pioneered this new take on prospective codes including this complex behavior. The paper would not have been possible without the help of Danielle Cushing. Link for the smart PDF: rdcu.be/enokS

New information triggers prospective codes to adapt for flexible navigation

Nature Communications - Neural mechanisms underlying flexible navigation are not fully understood. Here authors reveal how neural circuits dynamically adapt navigational plans in response to new...

rdcu.be

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Annabelle Singer @drannabellesinger.bsky.social · May 28

These findings clarify long-standing debates about whether these codes steer behavior towards upcoming choices or represent all possible paths.

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Annabelle Singer @drannabellesinger.bsky.social · May 28

Finally, we find that hippocampal representations of the new future goal increased more when animals needed to adapt their behavior more in response to the new information. This shows that the degree of adaptation needed is a key overlooked variable regulating prospective codes.

a man in a blue jacket says " adapt or die " in a movie scene

ALT: a man in a blue jacket says " adapt or die " in a movie scene

media.tenor.com

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Annabelle Singer @drannabellesinger.bsky.social · May 28

This shows for the first time that prospective codes are actively modulated by new task-relevant information.

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Annabelle Singer @drannabellesinger.bsky.social · May 28

In hippocampus, we found that new, pivotal information causes non-local representations of both possible goal locations to rapidly increase, simulating both possible outcomes. In prefrontal cortex we found that pivotal information causes choice codes to rapidly switch to represent the new choice.

a young boy is eating a piece of ice cream .

ALT: a young boy is eating a piece of ice cream .

media.tenor.com

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Annabelle Singer @drannabellesinger.bsky.social · May 28

To do this, Steph developed a new behavioral paradigm in which we leverage a dynamic, virtual-reality environment to precisely control the introduction of new information while animal’s choices are evolving in a memory-based decision-making task.

a cartoon drawing of minnie mouse wearing a red dress with white polka dots

ALT: a cartoon drawing of minnie mouse wearing a red dress with white polka dots

media.tenor.com

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Annabelle Singer @drannabellesinger.bsky.social · May 28

We live in a dynamic world, but we often study navigation as if the world is static. So how do we flexibly adapt in the face of new, pivotal information? @stephmprince.bsky.social addresses just that question in her latest paper: www.nature.com/articles/s41....

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Reposted by Annabelle Singer

Steph Prince @stephmprince.bsky.social · May 27

Excited to share the last project from my PhD is officially published: www.nature.com/articles/s41...!

New information triggers prospective codes to adapt for flexible navigation - Nature Communications

Neural mechanisms underlying flexible navigation are not fully understood. Here authors reveal how neural circuits dynamically adapt navigational plans in response to new information. Hippocampal circ...

www.nature.com

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