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drelmira.bsky.social
Elmira
@drelmira.bsky.social
14 followers 12 following 6 posts
leukemia postdoc in Peggy Goodell’s lab. Houston.
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drelmira.bsky.social
Elmira @drelmira.bsky.social · Apr 16
We discuss how repurposing of widely used anti-diabetes drugs may offer a strategy for individuals with CH, highlighting precautions like risk-stratification and pointing out future research directions. Open access: rdcu.be/eh0OF
Age-related blood condition counteracted with a common diabetes drug | Nature
Metformin could reduce people’s risk of certain age-associated blood cancers, but more work is needed to identify who is likely to benefit. Metformin could reduce people’s risk of certain age-associated blood cancers, but more work is needed to identify who is likely to benefit.
rdcu.be
drelmira.bsky.social
Elmira @drelmira.bsky.social · Apr 16
DNMT3A mutant cells have reduced methylation at specific loci and a distinct metabolism compared to healthy cells. DNMT3A mutant cells are vulnerable to inhibition of oxidative phosphorylation. Metformin and MitoQ can block CH clone expansion in murine and human models.
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drelmira.bsky.social
Elmira @drelmira.bsky.social · Apr 16
www.nature.com/articles/d41...
Age-related blood condition counteracted with a common diabetes drug
Metformin could reduce people’s risk of certain age-associated blood cancers, but more work is needed to identify who is likely to benefit.
www.nature.com
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drelmira.bsky.social
Elmira @drelmira.bsky.social · Apr 16
Excited to share the @goodell-lab.bsky.social News&Views on 3 exciting studies by Vassiliou Lab, Chan Lab, and @trowbridgelab.bsky.social in @nature.com and @natcomms.nature.com, showing that #DNMT3A mutant (major driver of Clonal Hematopoiesis) blood cells depend on mitochondrial respiration.
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drelmira.bsky.social
Elmira @drelmira.bsky.social · Dec 3
Going to ASH in San Diego! It was my dream to attend this conference when I was a PhD student and now I am going for the second time as a postdoc.
drelmira.bsky.social
Elmira @drelmira.bsky.social · Nov 27
Hi! My name is Elmira. I am a postdoc in Dr Goodell’s lab in Houston. Working on leukemia development, epigenetic deregulation in blood cells, clonal hematopoiesis. Doing CRISPR in primary cells and cool imaging.

I am sharing my science journey on different platforms since 2014.