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drjonhedley.bsky.social
Jonathan Hedley
@drjonhedley.bsky.social
7 followers 10 following 1 posts
Novo Nordisk Postdoctoral Research Fellow in the Torr Vision Group @ University of Oxford 🧬👨‍🔬 PhD in Chemical Physics ⚗️🧪Opera singer on the side 🎶🎵
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drjonhedley.bsky.social
Jonathan Hedley @drjonhedley.bsky.social · Sep 4
Happy to have developed the theory here, linking sequence-dependent charge patterns to favourable electrostatic interactions between homologous dsDNA🧬🧬

Matching theory & expt suggests a physical basis for sequence recognition that may underpin aspects of recombination, DNA repair, and replication.
dimichelelab1.bsky.social
Di Michele Lab @dimichelelab1.bsky.social · Aug 31
It turns out sDNA 🧬 interacts selectively! Andy Stannard measured these interactions very (very) precisely, and Ehud Haimov, @drjonhedley.bsky.social‬, Alexei Kornyshev worked out how it all works. It has to do with charge correlation... Check it out here
chemrxiv.org/engage/chemr...
Detection and quantification of counterion-mediated homologous recognition in double-stranded DNA
Stretches of double-stranded DNA sharing the same sequence can recognise each other in cells. This phenomenon, known as homologous recognition, is essential for DNA recombination and repair. Yet, its ...
chemrxiv.org
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