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Reposted by Philip Dunne

Simon Leedham @leedham-simon.bsky.social · Jun 7

Finally out! A longstanding project to explore the mechanism behind ectopic crypt formation in polyps when GREM1 is aberrantly expressed in HMPS patients. Turns out it is all to do with stromal remodelling and epithelial-mesenchymal interdependence!
www.nature.com/articles/s41...

Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling - Nature Communications

The authors show that aberrant epithelial GREM1 expression remodels intestinal stroma to form ectopic stem cell niches in mice. Anti-GREM1 reversed these changes, highlighting a potential strategy for...

www.nature.com

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Simon Leedham @leedham-simon.bsky.social · 28d

New review on the importance of intestinal epithelial-mesenchymal crosstalk - from development and homeostasis through to regeneration to neoplasia. Excellent collaboration with Frances England, Manquiang Lin and Michael Sigal

www.nature.com/articles/s41...

Defining the mucosal ecosystem: epithelial–mesenchymal interdependence in gastrointestinal health and disease - Nature Reviews Gastroenterology & Hepatology

This Review focuses on epithelial–mesenchymal crosstalk and how these interactions shape development, health and disease in the intestinal mucosa. The dynamic nature of this ecosystem is highlighted, ...

www.nature.com

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Reposted by Philip Dunne

Cassie Clarke @cassiejclarke.bsky.social · Jul 28

And the original publication is here:
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports share.google/JXMzGDRzpl0E...

Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports

imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibronectin deposition and support metastatic niche ...

share.google

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Cassie Clarke @cassiejclarke.bsky.social · Jul 28

It was a pleasure to speak to Lucy Whyte this morning on #BBCRadioScotland to discuss our recent @emboreports.org publication which has discovered how #neutrophil #metabolism facilitates #metastasis. Catch up with interview here: www.youtube.com/watch?v=tUUw...

Dr Cassie Clarke CRUK Scotland Institute - breast cancer research

YouTube video by Fiona MacLeod

www.youtube.com

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Nadia Nasreddin @nadianasreddin.bsky.social · Jul 25

✨Thrilled to announce an exciting opportunity to work on our project exploring WNT-driven cell competition as a novel preventative strategy in CRC 🧬

We’re hiring a Senior Scientific Officer to join me in @owen_sansom’s lab. Great science and lots of room to make an impact! 👩🏽‍🔬

Cancer Research UK Scotland Institute @cruk-si.bsky.social · Jul 25

We are recruiting a Senior Scientific Officer to work with @nadianasreddin.bsky.social in the Sansom lab on the project WNT-driven cell competition: a target for novel preventative strategies against colorectal adenoma formation

📅Apply by 15 August 2025

www.crukscotlandinstitute.ac.uk/careers/

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Philip Dunne @drpipdunne.bsky.social · Jul 28

Excellent opportunity to work with a wonderful team 👇👇💥

Nadia Nasreddin @nadianasreddin.bsky.social · Jul 25

✨Thrilled to announce an exciting opportunity to work on our project exploring WNT-driven cell competition as a novel preventative strategy in CRC 🧬

We’re hiring a Senior Scientific Officer to join me in @owen_sansom’s lab. Great science and lots of room to make an impact! 👩🏽‍🔬

Cancer Research UK Scotland Institute @cruk-si.bsky.social · Jul 25

We are recruiting a Senior Scientific Officer to work with @nadianasreddin.bsky.social in the Sansom lab on the project WNT-driven cell competition: a target for novel preventative strategies against colorectal adenoma formation

📅Apply by 15 August 2025

www.crukscotlandinstitute.ac.uk/careers/

Reposted by Philip Dunne

Cancer Research UK Scotland Institute @cruk-si.bsky.social · Jul 25

We are recruiting a Senior Scientific Officer to work with @nadianasreddin.bsky.social in the Sansom lab on the project WNT-driven cell competition: a target for novel preventative strategies against colorectal adenoma formation

📅Apply by 15 August 2025

www.crukscotlandinstitute.ac.uk/careers/

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Philip Dunne @drpipdunne.bsky.social · May 14

Sunshine and science in Glasgow today at the CRC-STARS kick off meeting

Excellent presention from Raheleh in our team charting phenotypic evolution during cancer development and progression, and how best we can use preclinical models of cancer to improve patient outcomes

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Philip Dunne @drpipdunne.bsky.social · Apr 30

AACR.. over and out! Great couple of days in Chicago, brilliant to catch up with so many collaborators and make new connections. Coming home brimming with new ideas to take into our @cruk-si.bsky.social early detection, @incise-research.bsky.social, & CRC-STARS programmes

#AACR25

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Philip Dunne @drpipdunne.bsky.social · Apr 30

Incredibly proud to see Dr Fisher presenting her research at the @theaacr.bsky.social annual conference.

Understanding precancer biology is crucial for improving early detection, and preventing early cancer development and progression.

#AACR25

@nataliefisher.bsky.social

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Philip Dunne @drpipdunne.bsky.social · Apr 29

Session with Natalie’s talk starting shortly in room E351

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Sarah Aitken @s-j-aitken.bsky.social · Apr 26

bsky.app/profile/s-j-...

Sarah Aitken @s-j-aitken.bsky.social · Mar 26

My lab at hiring! - we have TWO postdoc positions (one computational, one wet lab focussed) at Yale @yaleschoolofmed.bsky.social, working closely with our group members at University of Cambridge, UK @cambridgeuni.bsky.social

Please help to spread the word!

Adverts with full details below ⬇️

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Reposted by Philip Dunne

Sarah Aitken @s-j-aitken.bsky.social · Apr 26

Yes! - we are hiring @yale.edu - links below...

Craig Anderson @craigandersn.bsky.social · Apr 25

I'm biased, but I loved it, great talk!! Don't forget @s-j-aitken.bsky.social is hiring! She's a great scientist and person- you couldn't find a better PI.

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Philip Dunne @drpipdunne.bsky.social · Apr 24

@cruk-si.bsky.social @qubelfastofficial.bsky.social @cancerresearchuk.org @incise-research.bsky.social @joedwardswwcrc.bsky.social

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Philip Dunne @drpipdunne.bsky.social · Apr 24

If you are Chicago bound watch out for Natalie & Sid presenting at #AACR2025 & come say hello!

Natalie's @theaacr.bsky.social Women in Cancer Research award talk covers how we can use biology to improve early detection of polyps

Sid's poster is on early tumour transcriptional landscapes

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · Apr 8

Network members secure new #funding aimed at developing new and personalised #therapeutic approaches for #ColorectalCancer nmgn.mrc.ukri.org?p=1808&previ... @drpipdunne.bsky.social @cancerresearchuk.org @cruk-si.bsky.social

Bowel Cancer in the Spotlight as Network Members Lead New Research Towards Personalised Treatment | National Mouse Genetics Network

MRC National Mouse Genetics Network (NMGN) members from the Cancer Cluster and the new Data Platform initiative are at the centre of a new project announced on the 31st of […]

nmgn.mrc.ukri.org

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Reposted by Philip Dunne

Edwards Lab @labedwards.bsky.social · Mar 26

Members of IMPACT span wet-lab scientists, pathologists, bioinformaticians, patient involvement managers, image analysts, technicians, clinicians, students, project managers, and lecturers among others, to ensure a wide range of expertise and optimum resource management!

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Edwards Lab @labedwards.bsky.social · Mar 26

With 5 distinct research groups led by @joedwardswwcrc.bsky.social, Campbell Roxburgh, Nigel Jamieson, Colin Steele, and @mcsorleystephen.bsky.social, IMPACT provides a human tissue-based translational research infrastructure in Glasgow, in collaboration with @drpipdunne.bsky.social and Xiao Fu! 🤝

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Edwards Lab @labedwards.bsky.social · Mar 26

Last week, the 1st Annual IMPACT conference took place on the shores of Loch Lomond 📍🤩

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Philip Dunne @drpipdunne.bsky.social · Mar 26

An absolutely brilliant few days in sunny Loch Lomond with my Glasgow colleagues 🏴󠁧󠁢󠁳󠁣󠁴󠁿☘️☀️

Edwards Lab @labedwards.bsky.social · Mar 26

Last week, the 1st Annual IMPACT conference took place on the shores of Loch Lomond 📍🤩

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Reposted by Philip Dunne

WntUK @wntuk.bsky.social · Mar 24

Many thanks WntUK ECR rep @nadianasreddin.bsky.social from @cruk-si.bsky.social for chairing the Future Generation session!

#WNTUK2025

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Nadia Nasreddin @nadianasreddin.bsky.social · Mar 25

Such an honour! Thank you to the organising committee for the opportunity and the great conference!!

WntUK @wntuk.bsky.social · Mar 24

Many thanks WntUK ECR rep @nadianasreddin.bsky.social from @cruk-si.bsky.social for chairing the Future Generation session!

#WNTUK2025

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Reposted by Philip Dunne

Christian Frezza @frezzalab.bsky.social · Mar 23

Congrats to @zanivanlab.bsky.social for this very interesting review: www.cell.com/cell-reports...

The tumor microenvironment is an ecosystem sustained by metabolic interactions

Cancer-associated fibroblasts and immune cells are known to interact within the tumor microenvironment and influence each other to impact on tumor progression. Here, Kay et al. discuss how they can al...

www.cell.com

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Philip Dunne @drpipdunne.bsky.social · Mar 17

A St Patrick’s Day treat ☘️

More excellent work from @aideenryan.bsky.social and her team, teasing apart the importance of stromal & immune communication networks in colorectal cancer 👇

bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · Mar 17

Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis https://www.biorxiv.org/content/10.1101/2025.03.14.642985v1

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bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · Mar 17

Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis https://www.biorxiv.org/content/10.1101/2025.03.14.642985v1

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