Lynne Postovit
@drpostovit.bsky.social
check out our newest preprint showing that #dedifferentiation in certain types of #endometrialcancers may be due to transcriptional chaos rather than cellular reprogramming
December 16, 2025 at 9:12 PM
check out our newest preprint showing that #dedifferentiation in certain types of #endometrialcancers may be due to transcriptional chaos rather than cellular reprogramming
Reposted by Lynne Postovit
☕Watt, Dauber, Szkop et al find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.
@kwattever.bsky.social @drpostovit.bsky.social @ki.se @queensuhealth.bsky.social
bit.ly/47IXjvX
@kwattever.bsky.social @drpostovit.bsky.social @ki.se @queensuhealth.bsky.social
bit.ly/47IXjvX
Epigenetic alterations facilitate transcriptional and translational programs in hypoxia - Nature Cell Biology
Watt, Dauber, Szkop and colleagues find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.
bit.ly
November 16, 2025 at 8:23 AM
☕Watt, Dauber, Szkop et al find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.
@kwattever.bsky.social @drpostovit.bsky.social @ki.se @queensuhealth.bsky.social
bit.ly/47IXjvX
@kwattever.bsky.social @drpostovit.bsky.social @ki.se @queensuhealth.bsky.social
bit.ly/47IXjvX
Our newest paper is out. Here we show that hypoxia induces epigenomic alterations that change where transcripts start. This changes the 5'UTR sequences which then regulate translational efficiency. We think that this is an important regulator of the hypoxic proteome www.nature.com/articles/s41...
Epigenetic alterations facilitate transcriptional and translational programs in hypoxia - Nature Cell Biology
Watt, Dauber, Szkop and colleagues find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.
www.nature.com
October 16, 2025 at 9:47 PM
Our newest paper is out. Here we show that hypoxia induces epigenomic alterations that change where transcripts start. This changes the 5'UTR sequences which then regulate translational efficiency. We think that this is an important regulator of the hypoxic proteome www.nature.com/articles/s41...