Therapeutics Initiative
@drug-evidence.bsky.social
1.4K followers 1.2K following 340 posts
UBC-based, independent, evidence-informed, practical #BetterPrescribing resources for physicians, pharmacists, & nurse practitioners. ti.ubc.ca #medsky #pharmsky
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drug-evidence.bsky.social
🆕 UBC TI Therapeutics Letter 158

Improving how we prescribe #zopiclone and #trazodone for insomnia ti.ubc.ca/letter158

RCTs: small improvements for about 1 in 12 people

If prescribing zopiclone, start at 3.75mg, don't exceed 7.5mg (5mg in older pts)

Pts shd do 1wk sleep diary before/after any 💊
drug-evidence.bsky.social
🚨 ICYMI: UBC TI Therapeutics Letter 156: Antidepressant withdrawal syndrome – Update
👉 ti.ubc.ca/letter156

Antidepressants can be helpful for some people; but starting or
stopping requires care

Knowing about types of possible withdrawal problems helps prescribers guide patients in 🛑 more safely
drug-evidence.bsky.social
🚨 TI #BestEvidence webinar recording 😍

The TI's Dr. Anshula Ambasta discusses
"Thyroid testing for primary hypothyroidism"
👉 www.youtube.com/watch?v=8-QN...

See also:
TI Therapeutics Letter: ti.ubc.ca/letter154
TI Prescribing Portrait: ti.ubc.ca/thyroid-port...

#MedEd #diagnosis
Dr. Anshula Ambasta: Thyroid testing for primary hypothyroidism.
YouTube video by Therapeutics Initiative
www.youtube.com
Reposted by Therapeutics Initiative
drotte.medsky.social
another TI @drug-evidence.bsky.social + collaborators publication:

It is possible to reduce the unnecessary over-use of TSH and related #thyroid tests!!! But it can be a challenge!

(DM me to ask how I know!)

qualitysafety.bmj.com/content/qhc/...

#choosingwisely #overtesting
drug-evidence.bsky.social
ICYMI: TI #BestEvidence webinar recording 🚨
Highlights from TI Portrait

Featuring the TI's Dr. Aaron Tejani
👉 youtube.com/watch?v=-5V9...

Sign up for TI Portrait here: ti.ubc.ca/portrait

#prescribing #MedEd #BetterPrescribing
Dr. Aaron Tejani: Highlights from TI Portrait.
YouTube video by Therapeutics Initiative
youtube.com
drug-evidence.bsky.social
🆕 TI #BestEvidence webinar recording

Using your TI Prescribing Portrait & mysleepwell.ca for optimal #insomnia management

🎤 Speakers: Dr. Aaron Tejani + Dr. David Gardner
👩🏽‍💻 Video: www.ti.ubc.ca/insomnia-por...

#PrescribingPortraits #MedEd #deprescribing
drug-evidence.bsky.social
ICYMI: Our MOST-VIEWED #Deprescribing webinar ever 👇🏽

Antidepressant withdrawal effects & how to safely stop them🛑
youtube.com/watch?v=LRr0...

✅ Maudsley approach to deprescribing #antidepressants
✅ Hyperbolic tapering
✅ Distinguishing withdrawal effects

#MedEd #MedSafety
Dr. Mark Horowitz: Antidepressant withdrawal effects and how to safely stop them
YouTube video by Therapeutics Initiative
youtube.com
drug-evidence.bsky.social
🚨 ICYMI: UBC TI Therapeutics Letter 156: Antidepressant withdrawal syndrome – Update
👉 ti.ubc.ca/letter156

Antidepressants can be helpful for some people; but starting or
stopping requires care

Knowing about types of possible withdrawal problems helps prescribers guide patients in 🛑 more safely
drug-evidence.bsky.social
🚨ICYMI - #Deprescribing webinar recording! 😍

When making decisions about 🛑#statins, consider:

✅ patient values, preferences
✅ health status
✅ current evidence

Watch as the TI's Dr. Wade Thompson summarizes current evidence: tiny.cc/StatinDepres...
drug-evidence.bsky.social
See also: UBC TI Therapeutics Letter 158:

Improving how we prescribe zopiclone & trazodone for insomnia ti.ubc.ca/letter158
drug-evidence.bsky.social
🆕 TI #BestEvidence webinar recording

Using your TI Portrait & mysleepwell.ca for optimal #insomnia management

🎤 Speakers: Dr. Aaron Tejani + Dr. David Gardner
👩🏽‍💻 Video: www.ti.ubc.ca/insomnia-por...

#PrescribingPortraits #MedEd #deprescribing
@deprescribing.bsky.social @deprescribeus.bsky.social
drug-evidence.bsky.social
TI #BestEvidence Webinar

How can we think more critically about choosing #antibiotic treatment durations?

"Antimicrobial Durations in Practice: A Product of Magical Thinking in Medicine"

🕛 Oct 15 @ noon Pacific
🎤 Dr. Davie Wong
✍️ Register:
www.ti.ubc.ca/2025/09/24/a...

@absteward.bsky.social
drug-evidence.bsky.social
🚨TI #BestEvidence Webinar

How can we think more critically about choosing #antibiotic treatment durations?

"Antimicrobial Durations in Practice – A Product of Magical Thinking in Medicine"

🕛 Oct 15 @ noon Pacific

🎤 Speaker: Dr. Davie Wong

✍️ Details + Register:
www.ti.ubc.ca/2025/09/24/a...
Reposted by Therapeutics Initiative
drug-evidence.bsky.social
Patient Self-Guided Interventions to Reduce Sedative Use and Improve Sleep

"As a simple, scalable, direct-to-patient intervention, YAWNS-1 substantially reduced BZRA use and improved sleep outcomes"

pubmed.ncbi.nlm.nih.gov/39292452/

#insomnia #deprescribing #CBT
a kitten is sleeping under a blanket on a bed .
ALT: a kitten is sleeping under a blanket on a bed .
media.tenor.com
Reposted by Therapeutics Initiative
cochranehtn.bsky.social
🆕 @cochrane.org Review update 🆕

Pharmacotherapy for mild hypertension www.cochranelibrary.com/cdsr/doi/10....

In ppl w/ mildly elevated blood pressure (BP) w/out cardiovascular disease (CVD) or related health risks, BP meds may not reduce risk of death or of developing major CVD

#SystematicReview
Pharmacotherapy for mild hypertension - Wang, D - 2025 | Cochrane Library
Select your preferred language for Cochrane reviews and other content. Sections without translation will be in English.
www.cochranelibrary.com
drug-evidence.bsky.social
ICYMI - TI #BestEvidence Webinar recording: Oral vs IV Antibiotics
ti.ubc.ca/antibiotics-...

See also:

TI Therapeutics Letter on #antibiotics:
ti.ubc.ca/letter155

Patient handout: When are oral antibiotics the right choice?
ti.ubc.ca/antibiotics-...

#MedEd #CME #BetterPrescribing
Dr. Davie Wong: Oral vs IV antibiotics
YouTube video by Therapeutics Initiative
www.youtube.com
drug-evidence.bsky.social
Patient Self-Guided Interventions to Reduce Sedative Use and Improve Sleep

"As a simple, scalable, direct-to-patient intervention, YAWNS-1 substantially reduced BZRA use and improved sleep outcomes"

pubmed.ncbi.nlm.nih.gov/39292452/

#insomnia #deprescribing #CBT
a kitten is sleeping under a blanket on a bed .
ALT: a kitten is sleeping under a blanket on a bed .
media.tenor.com
drug-evidence.bsky.social
🚨TI #BestEvidence Webinar

How can we think more critically about choosing #antibiotic treatment durations?

"Antimicrobial Durations in Practice – A Product of Magical Thinking in Medicine"

🕛 Oct 15 @ noon Pacific

🎤 Speaker: Dr. Davie Wong

✍️ Details + Register:
www.ti.ubc.ca/2025/09/24/a...
drug-evidence.bsky.social
🚨TI #BestEvidence Webinar

How can we think more critically about choosing #antibiotic treatment durations?

"Antimicrobial Durations in Practice – A Product of Magical Thinking in Medicine"

🕛 Oct 15 @ noon Pacific

🎤 Speaker: Dr. Davie Wong

✍️ Details + Register:
ubc.zoom.us/meeting/regi...
Reposted by Therapeutics Initiative
lisamccarthy.bsky.social
I am always up for a chat with @jonathanunderhill.pharmsky.app! Kindred spirits united by a cranky elevator (aka lift) and @eahpofficial.bsky.social. Listen to the @prescqipp.info podcast... #deprescribing #ICOD2026
@deprescribing.bsky.social
@caden-recad.bsky.social @deprescribeus.bsky.social
deprescribing.bsky.social
Looking for a new podcast for your commute? 🎧

Check out the latest @prescqipp.info info #TalkingMeds podcast where our @deprescribing.bsky.social Co-Director @lisamccarthy.bsky.social and host @jonathanunderhill.pharmsky.app discuss person-centered deprescribing, ICOD 2026, and more!
prescqipp.info
Our next #TalkingMeds podcast drops tomorrow, 19 Sept!

Join @jonathanunderhill.pharmsky.app as he talks to University of Toronto Professor @lisamccarthy.bsky.social about deprescribing lessons we can learn from Canada.

Listen here: www.prescqipp.info/our-resource...

@deprescribing.bsky.social
drug-evidence.bsky.social
⌛ TODAY (Sept 24) @ Noon Pacific! 🕛

TI #BestEvidence webinar

Can we improve how we use zopiclone & trazodone for #insomnia? 💊🥱

🎤 Speakers: Dr Aaron Tejani + Dr David Gardner

✍️ Details + Register
www.ti.ubc.ca/2025/09/17/i...

#MedEd #prescribing #deprescribing #CME
Reposted by Therapeutics Initiative
drug-evidence.bsky.social
🚨Clinicians, how can you improve your #prescribing of zopiclone and trazodone for #insomnia?

✅ TI Therapeutics Letter 158: ti.ubc.ca/letter158

✅ TI Prescribing Portrait: www.ti.ubc.ca/2025/09/17/i...

✅ TI #BestEvidence webinar: www.ti.ubc.ca/2025/09/17/i...
drug-evidence.bsky.social
⌛ TOMORROW (Sept 24) @ Noon Pacific! 🕛

TI #BestEvidence webinar

Can we improve how we use zopiclone & trazodone for #insomnia? 💊🥱

🎤 Speakers: Dr Aaron Tejani + Dr David Gardner

✍️ Details + Register
www.ti.ubc.ca/2025/09/17/i...

#MedEd #prescribing #deprescribing #CME
drug-evidence.bsky.social
🚨Clinicians, how can you improve your #prescribing of zopiclone and trazodone for #insomnia?

✅ TI Therapeutics Letter 158: ti.ubc.ca/letter158

✅ TI Prescribing Portrait: www.ti.ubc.ca/2025/09/17/i...

✅ TI #BestEvidence webinar: www.ti.ubc.ca/2025/09/17/i...
Reposted by Therapeutics Initiative
prescqipp.info
Our next #TalkingMeds podcast drops tomorrow, 19 Sept!

Join @jonathanunderhill.pharmsky.app as he talks to University of Toronto Professor @lisamccarthy.bsky.social about deprescribing lessons we can learn from Canada.

Listen here: www.prescqipp.info/our-resource...

@deprescribing.bsky.social
Reposted by Therapeutics Initiative
drug-evidence.bsky.social
🚨Clinicians, how can you improve your #prescribing of zopiclone and trazodone for #insomnia?

✅ TI Therapeutics Letter 158: ti.ubc.ca/letter158

✅ TI Prescribing Portrait: www.ti.ubc.ca/2025/09/17/i...

✅ TI #BestEvidence webinar: www.ti.ubc.ca/2025/09/17/improve-use-zopiclone-trazodone-for-insomnia