Also our thanks to #Gerry_Nicholaes #Hector_Bueno and many others who were important collaborators
Support always from #CNIC #Yale_VBT @yaleschoolofmed.bsky.social
And very special to @caixaresearch.bsky.social for funding this work

Kudos to @Aleejandra__ and the amazing #Sandra_Martin that performed tons of MI work including a full circadian experiment!
This would have not been possible with the generous support of @casanova-acebes.bsky.social and @mariangelesmoro.bsky.social

Find out more here
rupress.org/jem/article/...

We then use a skin model to visualize the mechanism of this protection. The excitement came from finding that blocking the circadian clock repositions neutrophils right into the injury zone - thereby sparing the healthy tissue from the cytotoxicity of neutrophils

With #Lidiane_Torres we show this also protects the vasculature in sickle cell disease by blunting aggressive behaviors

We uncover a circadian “checkpoint” in neutrophils that naturally reduces inflammation by targeting their intrinsic circadian clock!
Activating CXCR4 represses circadian-related activation of neutrophils, critically reducing inflammatory injury to the infarcted heart

@yaleschoolofmed.bsky.social and importantly also #CNIC_Cardio

Our gratitude to those who helped us polish our ideas into a more decent text
@snarasimhan.bsky.social and the anonymous reviewers at @cp-cell.bsky.social
@casanova-acebes.bsky.social #Daniela_Quail @dcerezowallis.bsky.social #Laiguan_Ng

For a better understanding of where these ideas came from, check out our recent paper modeling the entire neutrophil compartment with @dcerezowallis.bsky.social #AndreaRubio and #Laiguan_Ng
www.nature.com/articles/s41...

Spoiler: We model the power of neutrophils as a reflection of their Collective behavior. Yes, just like insects… they become powerful. Here’s an idea of how this works

Kudos to the wonderful people in our labs who made this possible
@dcerezowallis.bsky.social #andrea_rubio #ivanbamartin #LaiguanNg

and to the many collaborators who helped us along the way and many many others.
Science is a team sport.

Kudos to @alazozcan.bsky.social, Tommaso, Yuval and Veronique for their insights and work for this review.

Immune cells are more than aggressors; they are also diplomats that prevent conflict by improving the barrier capacity, the ECM, and the mechanical properties of tissues. We are just beginning to scratch the true impact of immune cells on tissues and overall organismal physiology.