Reduction of HCC risk with GLP-1RA in diabetics? Comparisons between the GLP-1RA use group (n = 215,970) and the usual care group who continued use of non-GLP-1RA antihyperglycemics (n = 1,203,097), from the VA database. Risk reduction 18%.
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In compensated MASLD-cirrhosis metabolic surgery reduces the 15 year cumulative incidence of major adverse liver outcomes (MALO) (21% vs 46% without surgery) !⚠️observational study.
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Autologous macrophage therapy for cirrhosis: phase 2 open-label randomized controlled trial: During 360-d follow-up, control group developed 4 liver related events, and 3 deaths (2 liver related), whereas no liver-related severe adverse events or deaths occurred in the treatment group.

More on coffee benefits. Timing. Beginning your day with a coffee rather than finishing your day with a coffee is associated with a reduced mortality risk. shorturl.at/WGErS

In contrast to liver-specific MASLD (blue), cardiometabolic MASLD (red, characterized by dyslipidemia, hypertension, dysglycemia) results in a high risk of incident cardiovascular disease. shorturl.at/ZhFRC

Hepatic TM6SF2 activates antitumour immunity to
suppress MASLD-related HCC shorturl.at/M33WJ

Generally, women live longer than men, but not after the diagnosis of HCC. See doi: 10.3390/cancers16234023.