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Steven Cook @dumpyunc.bsky.social · 12h

I’m super excited about what we can achieve using light microscopy for human connectomics and projectomics and would discuss with anyone interested!

Steven Cook @dumpyunc.bsky.social · 12h

There are so many facets of a connectomics pipeline to work on — histology, imaging, analysis, automation and more.

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Steven Cook @dumpyunc.bsky.social · 13h

Our group at the Allen Institute is recruiting a technician and postdoc to work on light microscopy-based connectomics. Please DM me or share with anyone you think may be interested in this NIH BRAIN CONNECTS funded project.

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Reposted by Steven Cook

Andrew Payne @andrewcpayne.bsky.social · 6d

E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.

Read more: e11.bio/blog/prism

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Reposted by Steven Cook

Nature Reviews Neuroscience @natrevneuro.nature.com · Aug 14

Synaptic connectomics: status and prospects — a Comment article by Davi D. Bock

@dddavi.bsky.social

#neuroscience #neuroskyence

www.nature.com/articles/s41...

Synaptic connectomics: status and prospects - Nature Reviews Neuroscience

High-throughput volume electron microscopy and deep learning-driven automated segmentation have revolutionized the mapping of neural circuits at the level of individual neurons and synapses, revealing...

www.nature.com

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Reposted by Steven Cook

Wei-Chung Allen Lee @darbly.bsky.social · Aug 3

With @megyounger.bsky.social's lab, et al., we present the first connectomics work in the disease-vector mosquito Aedes aegypti, revealing how its brain is wired to detect host cues.

Preprint: doi.org/10.1101/2025...

#Neuroscience #Connectomics #vEM #VectorBiology 🧪

Diagrams (top-left) of an adult female Ae. aegypti head and (bottom) a basiconic sensillum on maxillary palp (gray) which contain dendritic processes of olfactory sensory neurons (OSNs), including CO2-sensitive Gr3-expressing OSNs. OSN axons project centrally to the antennal lobes in the brain. On the right is a volumetric rendering of the mosquito brain neuropils including the antennal lobes (light blue) (Heinze et al., 2021; Matthews et al., 2019). Scale bar 100 μm.

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Reposted by Steven Cook

Wei-Chung Allen Lee @darbly.bsky.social · Aug 3

How is the nervous system organized to coordinate behavior? To approach this massive question, a team led by @asbates.bsky.social, @jasper-tms.bsky.social, @mindyisminsu.bsky.social, & Helen Yang present the BANC: a Brain and Nerve Cord connectome.

Preprint: doi.org/10.1101/2025...

🧪#Neuroskyence

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Steven Cook @dumpyunc.bsky.social · Jul 31

Nice perspective by Ahmed and Hiesinger here: www.science.org/doi/10.1126/...

The mind of a predatory worm

Widespread neural connectivity changes underlie a behavioral switch between worm species

www.science.org

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Steven Cook @dumpyunc.bsky.social · Jul 31

Happy to share our publication - Comparative connectomics of two distantly related nematode species reveals patterns of nervous system evolution www.science.org/doi/10.1126/...

Comparative connectomics of two distantly related nematode species reveals patterns of nervous system evolution

Understanding the evolution of the bilaterian brain requires a detailed exploration of the precise nature of cellular and subcellular differences between related species. We undertook an electron micr...

www.science.org

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Steven Cook @dumpyunc.bsky.social · Jun 30

No

John Murray @jisaacmurray.bsky.social · Jun 30

Worm25 has been absolutely fantastic so far-congrats to everyone for your amazing work! One striking change in the talks this year is it seems like the consensus number of neurons in the adult hermaphrodite has returned to 302 after a few years at 300. Is CAN back?

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Steven Cook @dumpyunc.bsky.social · Jun 30

I may not be at #worm25 but the real discussion endures

Michael Hendricks 🇨🇦 @michaelhendricks.bsky.social · Jun 30

The number of C. elegans neurons must always be contested, unknowable, liminal in order to maintain humility in our efforts to list, label, and categorize nature, which is indifferent to our schemas.

John Murray @jisaacmurray.bsky.social · Jun 30

Worm25 has been absolutely fantastic so far-congrats to everyone for your amazing work! One striking change in the talks this year is it seems like the consensus number of neurons in the adult hermaphrodite has returned to 302 after a few years at 300. Is CAN back?

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Steven Cook @dumpyunc.bsky.social · Mar 7

Credit to Curtis Loer for the running title!

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Steven Cook @dumpyunc.bsky.social · Mar 7

Thanks for bringing this to my attention, it’s sad to see that disinformation continues

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Steven Cook @dumpyunc.bsky.social · Jan 1

First bird of 2025: yellow-rumped warbler on the suet feeder

Steven Cook @dumpyunc.bsky.social · Dec 29

Glad we’re not the only household the intermingles real and LEGO plants

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Steven Cook @dumpyunc.bsky.social · Dec 29

Winter break’s challenge: organize and rebuild my LEGO sets from the early 90s

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Steven Cook @dumpyunc.bsky.social · Dec 16

We're looking for an Allen Institute summer intern interested in mapping single neuron projectomes/proteomes in the human brain! Happy to chat with anyone about the opportunity and please share with anyone you think may be interested.

alleninstitute.org/careers/inte...

Internship & Postbaccalaureate Programs

Students and early-career professionals in lab research, biology, neuroscience, immunology, and others should apply for our internships and fellowships.

alleninstitute.org

Steven Cook @dumpyunc.bsky.social · Dec 15

Yeah

Michael Eisen @mbeisen.bsky.social · Dec 15

I can haz $250m please

Steven Cook @dumpyunc.bsky.social · Dec 3

New social media platform, same truth: CAN isn’t a neuron

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