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David Weiss

@dweisslab.bsky.social

160 followers 110 following 6 posts

Professor of Infectious Diseases, Emory University School of Medicine. Director, Emory Antibiotic Resistance Center

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David Weiss @dweisslab.bsky.social · Jul 2

We show how bacteria can adapt to B-lactam stress by increasing the copy number of "wimpy" beta-lactamases to overcome new drugs/B-lactamase inhibitors, without de novo evolution. This threatens the beta-lactam dominated antibiotic pipeline.

Congrats @jakechoby.bsky.social and team!
rdcu.be/euijW

Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline

Nature Communications - Choby et al. show that dynamic increases in the copy number of preexisting β-lactamase genes in heteroresistance enables resistance of continua of cellular...

rdcu.be

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David Weiss @dweisslab.bsky.social · Jul 2

@jakechoby.bsky.social is a rockstar - I encourage students/postdocs looking for an amazing mentor and excited to investigate a new frontier in antibiotic resistance to join Jake at UNC to study heteroresistance and defeat superbugs!

Congrats, Jake and team on this exciting paper.

Jake Choby @jakechoby.bsky.social · Jul 2

Excited to share the work with @dweisslab.bsky.social‬ and great collaborators on how gene amplification generates dynamic heteroresistance to new beta-lactams, like cefiderocol. We hope drug developers will consider heteroresistance during antibiotic development rdcu.be/euijW

Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline

Nature Communications - Choby et al. show that dynamic increases in the copy number of preexisting β-lactamase genes in heteroresistance enables resistance of continua of cellular...

rdcu.be

Reposted by David Weiss

Victor J. Torres @torreslab.bsky.social · Jun 23

Alert! The abstract deadline for the Microbial Pathogenesis & Host Response meeting has been extended to July 7 meetings.cshl.edu/meetings.asp...

Microbial Pathogenesis & Host Response

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu

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David Weiss @dweisslab.bsky.social · Dec 10

Thanks, Jeff!

David Weiss @dweisslab.bsky.social · Dec 10

Thanks, Sunny!

David Weiss @dweisslab.bsky.social · Dec 2

Thanks so much, Lauren! We agree and had never considered this. Big kudos to Julia who was set on investigating this question and persisted through many ups and downs.

David Weiss @dweisslab.bsky.social · Dec 2

Bactericidal antibiotics release bacterial DNA that activates TLR9, while static antibiotics do not. This can profoundly impact treatment outcome. Should clinicians consider this when choosing antibiotics to prescribe?

Amazing work by Julia Gross and collaboration with Iain Fraser!
rdcu.be/d1Phk

Bactericidal antibiotic treatment induces damaging inflammation via TLR9 sensing of bacterial DNA

Nature Communications - The immunologic differences induced by bactericidal versus bacteriostatic antibiotics remain unclear. Gross et al. show that, in contrast to static antibiotics, cidal...

rdcu.be

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