Eddie Cliff
@eddiecliff.bsky.social
660 followers 190 following 15 posts
haematology registrar PMCC & RMH | research affiliate, PORTAL, BWH/HMS | evidence-based medicine & policy | lymphoma | myeloma | Fulbright | writer
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Reposted by Eddie Cliff
amarkelkar.bsky.social
The urgency is real—but the “Most Favored Nation” drug pricing policy is unlikely to deliver lasting reform. In @jama.com, @eddiecliff.bsky.social and I propose accelerating and strengthening Medicare drug price negotiation to align prices with value.
🔗 jamanetwork.com/journals/jam...
Reposted by Eddie Cliff
jama.com
JAMA @jama.com · Jul 28
Viewpoint: The reintroduction of the most favored nation pricing policy aims to curb high US drug prices but faces legal and operational challenges.

ja.ma/4lXJcYs
eddiecliff.bsky.social
Just out @jama.com, led by Ian Liu we review 10 years of nononcology accelerated approvals

12/50 vaccines
10 nonmalignant haem
11 neurology
5 nonvaccine ID

>60% conversions to regular approval based on surrogate endpoints
jamanetwork.com/journals/jam... @portalresearch.org @akesselheim.bsky.social
Reposted by Eddie Cliff
jama.com
JAMA @jama.com · Jul 14
The US FDA accelerated approval pathway spans many nononcologic diseases, especially nonmalignant hematology and neurology, with 25% for infectious disease vaccines.

https://ja.ma/4lRpuge
Regulatory and Clinical Outcomes of Nononcology Accelerated Approvals
Reposted by Eddie Cliff
majorajay.bsky.social
Currently at #EHA2025: @broeckelmann.bsky.social presenting our recent @thelancethaem.bsky.social commission on adverse events, starting with our paper (with @biostatgirl.bsky.social) on advancing the measurement & dissemination of AE data HT @eddiecliff.bsky.social #EHA25
Reposted by Eddie Cliff
eclinicalmed.bsky.social
🔍Presenting at #ASCO25 as a #poster and now LIVE on our website

Predictors of withdrawal of anticancer drug indications granted accelerated approval: a retrospective cohort study

Read the whole paper here: www.thelancet.com/journals/ecl...
#TheLancet #Oncology #OncologyResearch #MedSky
Reposted by Eddie Cliff
majorajay.bsky.social
Announcing the 1st paper of ‪@thelancethaem.bsky.social‬ Commission on Adverse Events, with Drs. @biostatgirl.bsky.social‬ & Thanarajasingam.

We review advances in measuring & reporting newly-described AEs and provide analytic & AE visualization tools for dissemination.

buff.ly/SchRHhq
Thread ⬇️🧵
eddiecliff.bsky.social
What steps can trialists, regulators, journals, editors, reviewers, sponsors & academics take to improve toxicity reporting & identification?

👇 check out this figure from our @thelancethaem.bsky.social adverse event commission

www.thelancet.com/journals/lan... @broeckelmann.bsky.social
Reposted by Eddie Cliff
broeckelmann.bsky.social
For the third (open access) paper, I was humbled to coordinate an international author panel to comprehensively summarize challenges, lessons learned and outline future strategies for tolerability assessment with novel, targeted therapeutic approaches: doi.org/10.1016/S235...
eddiecliff.bsky.social
The latest in a trio of meta-analyses by Tobias, David & Kai just out at Molecular Therapy, on non-relapse mortality after bispecific antibodies in lymphoma & myeloma.

>70% of non-relapse deaths are due to infection.

Need to prioritise measurement, reporting, prophylaxis, early intervention.
eddiecliff.bsky.social
Just out @jama.com

Led by Dr Hwang we show when oncology drugs withdrawn due to negative trials are still accessible off-abel, prescribing plummets anyway

Romidepsin a notable exception, unsurprising to lymphoma docs who use it in TFH lymphomas

jamanetwork.com/journals/jam... @portalresearch.org
eddiecliff.bsky.social
Delighted Piers Blombery joined us to discuss CAR transgenic T-cell lymphoproliferative neoplasms & all things post-CAR-T malignancies on Blood Cancer Talks, with a side helping of molecular haematology. We discuss Piers' recent NEJM paper plus recent MSKCC case w transgene integration into TP53.
eddiecliff.bsky.social
A real honour to have Dr Hagop Kantarjian, M.D. on the podcast to talk all things CML, including the recent ASCEMBL trial - a really enjoyable hour packed full of wisdom!

podcasts.apple.com/us/podcast/b...

Check out Blood Cancer Talks on your favourite podcast platform. #leusm #leukemia #cml
Blood Cancer Talks
Education Podcast · 57 Episodes · Updated Semimonthly
podcasts.apple.com
eddiecliff.bsky.social
Enticing data for axi-cel in high risk upfront DLBCL in ZUMA-12 3 year followup @BloodJournal

75% 3-year progression free survival

ashpublications.org/blood/articl...

Randomised ZUMA-23 data eagerly awaited

#lymsm #lymphoma
eddiecliff.bsky.social
Disappointing outcomes for CAR T cells in 31 patients with relapsed/refractory Burkitt lymphoma

Tricky disease to treat. Perhaps combo of chemo and bispecific might offer better long term control

ashpublications.org/blood/articl... #lymsm #lymphoma
Outcomes Among Adult Recipients of CAR T-cell Therapy for Burkitt Lymphoma
Key Points. Despite having relatively favorable disease kinetics, patients with relapsed/refractory BL who receive CAR T-cells have poor outcomes.Future tr
ashpublications.org
eddiecliff.bsky.social
SYMPATICO trial - RCT of venetoclax + ibrutinib vs ibr+placebo in R/R mantle cell lymphoma just out in Lancet Oncology

www.sciencedirect.com/science/arti... #lymphoma #lymsm
Reposted by Eddie Cliff
Also the importance of actually assessing clinical endpoints in confirmatory studies (pubmed.ncbi.nlm.nih.gov/38583175/) ... and completing them in a timely fashion (pubmed.ncbi.nlm.nih.gov/39373384/) - studies from @eddiecliff.bsky.social Ian Liu Joseph Daval at @portalresearch.org