EIRN
@eirn-health.bsky.social
Takes an environmental illness approach to conditions like #MECFS, #PTSD, chemical injury, #POTS, #MCAS and many others. Addresses issues like neuroinflammation in the CNS as an extension of inflammation in the periphery and brain regions. eirn.org
PTSD/Current Findings
(This is the best article I have read recently on PTSD.)
Yang L, Lu J, Zhao Z, Zhang Z, Yang W, Zhang G. Research Progress on Inflammation and Immune Dysregulation in PTSD.
pubmed.ncbi.nlm.nih.gov/40525295/
(This is the best article I have read recently on PTSD.)
Yang L, Lu J, Zhao Z, Zhang Z, Yang W, Zhang G. Research Progress on Inflammation and Immune Dysregulation in PTSD.
pubmed.ncbi.nlm.nih.gov/40525295/
Research Progress on Inflammation and Immune Dysregulation in PTSD - PubMed
Our findings suggest that immune system dysfunction and inflammation are integral components of PTSD pathology. Understanding the mechanisms of neuroinflammation and immune dysregulation could facilit...
pubmed.ncbi.nlm.nih.gov
June 30, 2025 at 2:18 PM
PTSD/Current Findings
(This is the best article I have read recently on PTSD.)
Yang L, Lu J, Zhao Z, Zhang Z, Yang W, Zhang G. Research Progress on Inflammation and Immune Dysregulation in PTSD.
pubmed.ncbi.nlm.nih.gov/40525295/
(This is the best article I have read recently on PTSD.)
Yang L, Lu J, Zhao Z, Zhang Z, Yang W, Zhang G. Research Progress on Inflammation and Immune Dysregulation in PTSD.
pubmed.ncbi.nlm.nih.gov/40525295/
Reposted by EIRN
This *checks notes* president once suggested *checks notes again* raking the forests *gasps* to suppress fires.
He has no credible grasp on any of the key issues. Totally unserious. And that’s why he was elected.
He has no credible grasp on any of the key issues. Totally unserious. And that’s why he was elected.
As a homeowner in North Carolina, I know first hand how this miserable human lied about the storm here and the response. Unfortunately, his lies helped get him elected. He is lying again. A true leader would focus on everything chance to help. America, the next 4 years are going to be tough.
January 8, 2025 at 11:48 PM
This *checks notes* president once suggested *checks notes again* raking the forests *gasps* to suppress fires.
He has no credible grasp on any of the key issues. Totally unserious. And that’s why he was elected.
He has no credible grasp on any of the key issues. Totally unserious. And that’s why he was elected.
SIRT1 is suppressed by inflammation and therefore is an issue in MECFS and LC. This may be why many of these conditions are prevalent in those conditions!
Activation of SIRT1 by SRT1720 Alleviates Dyslipidemia, Improves Insulin Sensitivity and Exhibits Liver-Protective Effects in Diabetic Rats on a High-Fat Diet: New Insights into the SIRT1/Nrf2/NFκB Signaling Pathway
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
January 7, 2025 at 12:30 PM
SIRT1 is suppressed by inflammation and therefore is an issue in MECFS and LC. This may be why many of these conditions are prevalent in those conditions!
SARS-CoV-2 spike protein activates NOX2-p66SHC axis via inhibiting SLAMF8 to promote thrombogenesis. www.researchsquare.com/article/rs-5572297/v1
SARS-CoV-2 spike protein activates NOX2-p66SHC axis via inhibiting SLAMF8 to promote thrombogenesis
COVID-19 associated coagulation abnormalities and thrombosis are life-threatening complications after SARS-CoV-2 infection. However, the underlying mechanisms are unclear. Here, we found that SARS-CoV...
www.researchsquare.com
January 6, 2025 at 2:41 PM
SARS-CoV-2 spike protein activates NOX2-p66SHC axis via inhibiting SLAMF8 to promote thrombogenesis. www.researchsquare.com/article/rs-5572297/v1
Reposted by EIRN
Good to see PEM/PENE finally discussed for what it is—failure of the body’s cells, tissues, and systems to accommodate and recover from loading. A simple, intuitive, and amply support shift in mindset with potentially revolutionary implications for the field.
A 2024 #MECFS Year in Review Points to Progress – A Profound Disruption in Energy Production www.healthrising.org/blog/2025/01... In study after study, two themes popped up again & again. Cells across #pwME’s bodies are exhausted & exhibit a “failure to respond” when exposed to stress"
A 2024 ME/CFS Year in Review Points to Progress - and a Profound Disruption in Energy Production - Health Rising
A year in review for chronic fatigue syndrome or ME/CFS findings evidence of cellular exhaustion in many levels caused by mitochondrial dysfunction.
www.healthrising.org
January 5, 2025 at 8:40 PM
Good to see PEM/PENE finally discussed for what it is—failure of the body’s cells, tissues, and systems to accommodate and recover from loading. A simple, intuitive, and amply support shift in mindset with potentially revolutionary implications for the field.
Reposted by EIRN
January 3, 2025 at 1:31 PM
Reposted by EIRN
Thanks to @thesicktimes.bsky.social @longcovidjustice.bsky.social @betsyladyzhets.bsky.social @mileswgriffis.bsky.social for the chance to contribute to this fact sheet.
New factsheet from The Sick Times @thesicktimes.bsky.social team:
"What are fatigue and Post-Exertional Malaise (PEM)?"
longcovidjustice.org/PEM
3-page PDF:
longcovidjustice.org/wp-content/u...
#LongCovid #MEcfs @betsyladyzhets.bsky.social ts.bsky.social @mileswgriffis.bsky.social
"What are fatigue and Post-Exertional Malaise (PEM)?"
longcovidjustice.org/PEM
3-page PDF:
longcovidjustice.org/wp-content/u...
#LongCovid #MEcfs @betsyladyzhets.bsky.social ts.bsky.social @mileswgriffis.bsky.social
December 27, 2024 at 5:06 PM
Thanks to @thesicktimes.bsky.social @longcovidjustice.bsky.social @betsyladyzhets.bsky.social @mileswgriffis.bsky.social for the chance to contribute to this fact sheet.
How do you handle a "stress test" with MECFS? My HR went up in the GP office and has referred me. I think it is POTS but want to be sure...
December 21, 2024 at 10:58 AM
How do you handle a "stress test" with MECFS? My HR went up in the GP office and has referred me. I think it is POTS but want to be sure...
The "clock" gene has been shown to be disturbed in MECFS and long covid. This study suggests that the disturbed "clock:" gene may influence inflammatory bowel disease. Not much of an abstract! www.cell.com/trends/molecular-medicine/abstract/S1471-4914(24)00309-5
The circadian clock in inflammatory bowel diseases
Inflammatory bowel diseases (IBDs) involve relapsing–remitting immune activation and inflammation. Both immune system activity and digestive tract function exhibit diurnal variations, regulated by the circadian clock. Disruption of this clock is linked to inflammation, suggesting that circadian regulators may play a pivotal role in the inflammatory process of IBD.
www.cell.com
December 8, 2024 at 12:38 PM
The "clock" gene has been shown to be disturbed in MECFS and long covid. This study suggests that the disturbed "clock:" gene may influence inflammatory bowel disease. Not much of an abstract! www.cell.com/trends/molecular-medicine/abstract/S1471-4914(24)00309-5
Melatonin may have benefits for Covid-19 by controlling the purinergic system link.springer.com/article/10.1007/s12031-024-02292-6
Melatonin’s Impact on Cytokine Storm and Modulation of Purinergic Receptors for COVID-19 Prognosis: A Mental Health Perspective - Journal of Molecular Neuroscience
In 2019, coronavirus disease 2019 (COVID-19) started a global health crisis and was associated with high rates of depression and anxiety. Both mental disorders and COVID-19 exhibit similarities in pat...
link.springer.com
December 8, 2024 at 12:37 PM
Melatonin may have benefits for Covid-19 by controlling the purinergic system link.springer.com/article/10.1007/s12031-024-02292-6
The supplement NAC shows benefits on the muscular system after exercise by reducing lactate. Implications for MECFS and LC! pmc.ncbi.nlm.nih.gov/articles/PMC11617117/
The impact of N‐acetylcysteine on lactate, biomarkers of oxidative stress, immune response, and muscle damage: A systematic review and meta‐analysis
N‐acetylcysteine (NAC) is a compound whose mechanism of action is intricately linked to the provision of cysteine for glutathione synthesis. It has been used in medicine and has also made significant ...
pmc.ncbi.nlm.nih.gov
December 8, 2024 at 12:36 PM
The supplement NAC shows benefits on the muscular system after exercise by reducing lactate. Implications for MECFS and LC! pmc.ncbi.nlm.nih.gov/articles/PMC11617117/
A new video on the itaconate shunt research for MECFS. New findings..https://t.co/GcB29u6HDR
December 6, 2024 at 11:54 AM
A new video on the itaconate shunt research for MECFS. New findings..https://t.co/GcB29u6HDR
" Particulate matter causes increased symptoms in MECFS and fibromyalgia. This new study shows nitrolysation that " leads to decreased expression of the major regulators of fatty acid oxidation, lipolysis and anti-inflammatory response" journals.physiology.org/doi/abs/10.1152/ajpcell.00385.2024
Inhalation Exposure to Airborne PM2.5 Attenuates Hepatic Metabolic Pathways through S-Nitrosylation of the Primary ER Stress Sensor | American Journal of Physiology-Cell Physiology
Inhalation exposure to airborne fine particulate matter (aerodynamic diameter < 2.5 µm, PM2.5) is known to cause metabolic dysfunction-associated steatohepatitis (MASH) and the associated metabolic sy...
journals.physiology.org
December 1, 2024 at 12:08 PM
" Particulate matter causes increased symptoms in MECFS and fibromyalgia. This new study shows nitrolysation that " leads to decreased expression of the major regulators of fatty acid oxidation, lipolysis and anti-inflammatory response" journals.physiology.org/doi/abs/10.1152/ajpcell.00385.2024
"airborne UPM (ultra fine particulate matter) can exacerbate type 1 hypersensitivity reactions by enhancing the IgE-mediated signaling pathways within mast cells. t.co/iqKwmIdaJR
http://www.sciencedirect.com/science/article/abs/pii/S0304389424032862
t.co
December 1, 2024 at 12:07 PM
"airborne UPM (ultra fine particulate matter) can exacerbate type 1 hypersensitivity reactions by enhancing the IgE-mediated signaling pathways within mast cells. t.co/iqKwmIdaJR
Reposted by EIRN
#Circadian Intervention Improves #Parkinson’s Disease and May Slow Disease Progression: A Ten Year Retrospective Study
www.mdpi.com/3068018
www.mdpi.com/3068018
November 30, 2024 at 3:18 PM
#Circadian Intervention Improves #Parkinson’s Disease and May Slow Disease Progression: A Ten Year Retrospective Study
www.mdpi.com/3068018
www.mdpi.com/3068018
Cold, Flu Virus Can Trigger Long COVID Relapses
Tinker Ready. You have to provide email to read..
www.medscape.com/viewarticle/cold-flu-virus-can-trigger-long-covid-relapses-2024a1000cau?st=fpf_login&scode=msp&socialSite=facebook&form=login&icd=login_success_fb_match_fpf
Tinker Ready. You have to provide email to read..
www.medscape.com/viewarticle/cold-flu-virus-can-trigger-long-covid-relapses-2024a1000cau?st=fpf_login&scode=msp&socialSite=facebook&form=login&icd=login_success_fb_match_fpf
Cold, Flu Virus Can Trigger Long COVID Relapses
Those who treat and research long COVID warn that viral persistence and reactivation are real risks for some patients.
www.medscape.com
November 30, 2024 at 1:39 PM
Cold, Flu Virus Can Trigger Long COVID Relapses
Tinker Ready. You have to provide email to read..
www.medscape.com/viewarticle/cold-flu-virus-can-trigger-long-covid-relapses-2024a1000cau?st=fpf_login&scode=msp&socialSite=facebook&form=login&icd=login_success_fb_match_fpf
Tinker Ready. You have to provide email to read..
www.medscape.com/viewarticle/cold-flu-virus-can-trigger-long-covid-relapses-2024a1000cau?st=fpf_login&scode=msp&socialSite=facebook&form=login&icd=login_success_fb_match_fpf
Diet and stress are two environmental factors that most impact inflammatory bowel disease!
medauth2.mdedge.com/content/environmental-factors-ibd-diet-and-stress
medauth2.mdedge.com/content/environmental-factors-ibd-diet-and-stress
Environmental Factors in IBD: Diet and Stress | MDedge
medauth2.mdedge.com
November 30, 2024 at 12:58 PM
Diet and stress are two environmental factors that most impact inflammatory bowel disease!
medauth2.mdedge.com/content/environmental-factors-ibd-diet-and-stress
medauth2.mdedge.com/content/environmental-factors-ibd-diet-and-stress
Mapping the Potential Genes and Associated Pathways Involved in Long COVID-Associated Brain Fog Using Integrative Bioinformatics and Systems Biology Strategy.
link.springer.com/article/10.1007/s12033-024-01324-1
link.springer.com/article/10.1007/s12033-024-01324-1
Mapping the Potential Genes and Associated Pathways Involved in Long COVID-Associated Brain Fog Using Integrative Bioinformatics and Systems Biology Strategy - Molecular Biotechnology
One of the recent emerging global health issues is long COVID. Among long COVID patients, long COVID-associated brain fog is an important area. We noted an immense gap in understanding the genes and a...
link.springer.com
November 30, 2024 at 12:57 PM
Mapping the Potential Genes and Associated Pathways Involved in Long COVID-Associated Brain Fog Using Integrative Bioinformatics and Systems Biology Strategy.
link.springer.com/article/10.1007/s12033-024-01324-1
link.springer.com/article/10.1007/s12033-024-01324-1
Microbial melatonin metabolism in the human intestine as a therapeutic target for dysbiosis and rhythm disorders www.nature.com/articles/s41522-024-00605-6
Microbial melatonin metabolism in the human intestine as a therapeutic target for dysbiosis and rhythm disorders - npj Biofilms and Microbiomes
npj Biofilms and Microbiomes - Microbial melatonin metabolism in the human intestine as a therapeutic target for dysbiosis and rhythm disorders
www.nature.com
November 30, 2024 at 12:56 PM
Microbial melatonin metabolism in the human intestine as a therapeutic target for dysbiosis and rhythm disorders www.nature.com/articles/s41522-024-00605-6
Reposted by EIRN
I wrote this for a friend who needed a low cognitive load explanation of genes and genetic variants to help her understand a genetic report.
Sharing in case it helps anyone else 🧬
- Genes 🧬 are like recipes that tell the body how to make something
- We all have the same set of genes
Sharing in case it helps anyone else 🧬
- Genes 🧬 are like recipes that tell the body how to make something
- We all have the same set of genes
November 26, 2024 at 9:46 AM
I wrote this for a friend who needed a low cognitive load explanation of genes and genetic variants to help her understand a genetic report.
Sharing in case it helps anyone else 🧬
- Genes 🧬 are like recipes that tell the body how to make something
- We all have the same set of genes
Sharing in case it helps anyone else 🧬
- Genes 🧬 are like recipes that tell the body how to make something
- We all have the same set of genes
Thus, we propose that macrophage-derived itaconate promotes anemia during an inflammatory response in the erythroid compartment. ashpublications.org/bloodadvances/article/5/23/4831/476803/The-immunometabolite-itaconate-inhibits-heme
The immunometabolite itaconate inhibits heme synthesis and remodels cellular metabolism in erythroid precursors
Key Points. The immunometabolite itaconate is taken up by erythroid precursors and converted to itaconyl-CoA by the CoA transferase SUGCT.Itaconyl-CoA is a
ashpublications.org
November 24, 2024 at 2:10 PM
Thus, we propose that macrophage-derived itaconate promotes anemia during an inflammatory response in the erythroid compartment. ashpublications.org/bloodadvances/article/5/23/4831/476803/The-immunometabolite-itaconate-inhibits-heme
"Itaconate, therefore, alters the balance of CoA species in mitochondria through its impacts on TCA, amino acid, vitamin B12, and CoA metabolism." www.mdpi.com/2218-1989/11/2/117
Itaconate Alters Succinate and Coenzyme A Metabolism via Inhibition of Mitochondrial Complex II and Methylmalonyl-CoA Mutase
Itaconate is a small molecule metabolite that is endogenously produced by cis-aconitate decarboxylase-1 (ACOD1) in mammalian cells and influences numerous cellular processes. The metabolic consequence...
www.mdpi.com
November 24, 2024 at 1:48 PM
"Itaconate, therefore, alters the balance of CoA species in mitochondria through its impacts on TCA, amino acid, vitamin B12, and CoA metabolism." www.mdpi.com/2218-1989/11/2/117
Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-024-00599-5
Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier - Fluids and Barriers of the CNS
Background The Blood-Brain Barrier (BBB) is a complex and dynamic interface that regulates the exchange of molecules and cells between the blood and the central nervous system. It undergoes structural...
fluidsbarrierscns.biomedcentral.com
November 24, 2024 at 1:27 PM
Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-024-00599-5