Lightnews — Scholar-powered news

Reposted by Elisabetta Mereu

Stefanie Grosswendt @stefaniegrosswendt.bsky.social · May 13

The Berlin crew Ashley Sanders @simonhaas.bsky.social @leifludwig.bsky.social @stefaniegrosswendt.bsky.social is passing the torch to our co-organizers and partners in crime @elimereu.bsky.social @larsplus.bsky.social @alejofraticelli.bsky.social for ISCO 2026 in Barcelona
www.isco-conference.eu

2 9

Reposted by Elisabetta Mereu

Itai Yanai @itaiyanai.bsky.social · May 13

The Innovations in Single Cell Omics conference in Berlin was amazing! Great talks and we even had a Night Science workshop! 🙏 @stefaniegrosswendt.bsky.social, Ashley Sanders, @simonhaas.bsky.social, @leifludwig.bsky.social, @elimereu.bsky.social, @larsplus.bsky.social & @alejofraticelli.bsky.social

Stefanie Grosswendt @stefaniegrosswendt.bsky.social · May 13

Just wrapped up 2 inspiring days at ISCO – Innovations in Single Cell Omics! A great community came together to share science and fun. A big THANK YOU to all our fantastic speakers and interactive participants

(Some of the) speakers and co-organizers of the ISCO conference 2025

4 31

Reposted by Elisabetta Mereu

CarrerasLeaders @carrerasleaders.bsky.social · May 8

Meet Alessia Buratin 👩‍🔬

She focuses on Single Cell Multi Omics and Deep Learning Approach to reverse immunosuppression in Multiple Myeloma, under the supervision of Dra @elimereu.bsky.social at @carrerasijc.bsky.social.

Read about Alessia and her project: carrerasleaders.eu/postdoctoral...

1 5

Elisabetta Mereu @elimereu.bsky.social · May 6

Congrats Sergi, María & the whole team!

Reposted by Elisabetta Mereu

Josep Carreras Leukaemia Research Institute @carrerasijc.bsky.social · Apr 22

We're pleased to announce that Dr Ari Melnick has been appointed new Director of the Josep Carreras Institute.

Dr Melnick will lead IJC in our mission to advance #research in #leukaemia and other malignant blood diseases.

Read the full release here: www.carrerasresearch.org/en/news/dr-a...

6 13

Reposted by Elisabetta Mereu

Elana Fertig, PhD @fertiglab.bsky.social · Apr 15

Proud of our new perspective describing the role of mathematical biology for immunotherapy www.nature.com/articles/s41... @natbiotech.nature.com

Virtual cells for predictive immunotherapy - Nature Biotechnology

Synergizing advances in artificial intelligence with mathematical modeling will improve our ability to computationally predict immunotherapy outcomes.

www.nature.com

1 7 41

Reposted by Elisabetta Mereu

Ming Tommy Tang @tommytang.bsky.social · Mar 30

Epigenetic enhancement of adoptive T cell immunotherapy www.cell.com/cancer-cell...

2 2

Elisabetta Mereu @elimereu.bsky.social · Mar 24

Ohh sure!! Nice to hear from you Davis! 😎

1

Reposted by Elisabetta Mereu

Luciano Martelotto @lgmartelotto.bsky.social · Mar 23

www.biorxiv.org/content/10.1...

Protocol Optimization Improves the Performance of Multiplexed RNA Imaging

Spatial transcriptomics has emerged as a powerful tool to define the cellular structure of diverse tissues. One such method is multiplexed error robust fluorescence in situ hybridization (MERFISH). ME...

www.biorxiv.org

2 5

Elisabetta Mereu @elimereu.bsky.social · Mar 23

On my way to #Ascona in Switzerland) for this exciting congress, where we will discuss about modern benchmarking strategies to advance molecular biology!! Happy also to present our findings on the latest systematic evaluation of #singlecell multimodal data integrations in complex tissues. 🧬🔬👩🏻‍💻👩🏻‍🔬

Mark Robinson @markrobinsonca.bsky.social · Mar 5

Quick update. We have a pretty exciting lineup of topics/speakers in and around benchmarking that will be presented in Ascona at the end of the month:

sites.google.com/view/ascona2...

There are few registration slots left, so if you are interested to join us, get in touch.

1 2

Reposted by Elisabetta Mereu

Elisabetta Mereu @elimereu.bsky.social · Mar 10

🔬 Curious about the impact of #singlecell multimodal data on cell-type discovery? Check out our latest study: www.mereulab.org/post/do-we-r... .
📖 Too tired to read? No problem! 🎧 Listen to the NotebookLM #podcast included at the end of the post instead!

Do we really know the impact of multiple single-cell data types?

We often assume that single-cell sequencing gives us a complete picture of cellular diversity, but actually, we already saw in previous publications, like here and here, that one protocol is not reall...

www.mereulab.org

3 9

Reposted by Elisabetta Mereu

Itai Yanai @itaiyanai.bsky.social · Mar 13

Join us at "Innovations in Single Cell Omics" in Berlin 5.12-13 (+ night science workshop!)
www.isco-conference.eu
Organizers:
@stefaniegrosswendt.bsky.social, @simonhaas.bsky.social
@leifludwig.bsky.social, Ashley Sanders, @larsplus.bsky.social, @elimereu.bsky.social, @alejofraticelli.bsky.social

6 19

Elisabetta Mereu @elimereu.bsky.social · Mar 12

@leifludwig.bsky.social @simonhaas.bsky.social @stefaniegrosswendt.bsky.social

Reposted by Elisabetta Mereu

Elisabetta Mereu @elimereu.bsky.social · Mar 12

🚀 Join the #ISCO2025 community at @mdc-berlin.bsky.social on May 12-13! 🚀
Don't miss this incredible opportunity to connect with top #singlecell & #spatial omics experts and participate in a special Workshop led by @itaiyanai.bsky.social.
⏳Abstract submissions: March 21)
www.isco-conference.eu

ISCO - ISCO

www.isco-conference.eu

1 8 9

Elisabetta Mereu @elimereu.bsky.social · Mar 12

🚀 Join the #ISCO2025 community at @mdc-berlin.bsky.social on May 12-13! 🚀
Don't miss this incredible opportunity to connect with top #singlecell & #spatial omics experts and participate in a special Workshop led by @itaiyanai.bsky.social.
⏳Abstract submissions: March 21)
www.isco-conference.eu

ISCO - ISCO

www.isco-conference.eu

1 8 9

Elisabetta Mereu @elimereu.bsky.social · Mar 10

📖 Too tired to read? No problem! 🎧 Listen to the #NotebookLM podcast at the end of the post here: www.mereulab.org/post/do-we-r...

1 7

Elisabetta Mereu @elimereu.bsky.social · Mar 10

🔬 Curious about the impact of #singlecell multimodal data on cell-type discovery? Check out our latest study: www.mereulab.org/post/do-we-r... .
📖 Too tired to read? No problem! 🎧 Listen to the NotebookLM #podcast included at the end of the post instead!

Do we really know the impact of multiple single-cell data types?

We often assume that single-cell sequencing gives us a complete picture of cellular diversity, but actually, we already saw in previous publications, like here and here, that one protocol is not reall...

www.mereulab.org

3 9

Reposted by Elisabetta Mereu

Holger Heyn @hoheyn.bsky.social · Mar 7

Ever wondered why we do all these #Omics?
Here is your answer: biorxiv.org/content/10.1... 📜

Multi-Omics integration of a Human Cell Atlas
@humancellatlas.org of the Kidney, coordinated by the #HCA Standards and Technology Working Group and co-led by
@elimereu.bsky.social.

Systematic evaluation of single-cell multimodal data integration for comprehensive human reference atlas.

The integration of multimodal single-cell data enables comprehensive organ reference atlases, yet its impact remains largely unexplored, particularly in complex tissues. We generated a benchmarking da...

biorxiv.org

1 1 4

Elisabetta Mereu @elimereu.bsky.social · Mar 7

Led by @marioacera.bsky.social and #JessicaLi from my group @carrerasijc.bsky.social, alongside #XianAdiconis from #JoshuaLevin’s lab at @broadinstitute.org , and supported by many collaborators, this study is a multidisciplinary effort, bridging kidney biology, genomics, and computational science.

1

Elisabetta Mereu @elimereu.bsky.social · Mar 7

✅ Introducing #scOMM, a new interpretable machine learning tool for multimodal cell-type classification & benchmarking.

github.com/mereulab/scOMM

GitHub - mereulab/scOMM: Source code for scOMM

Source code for scOMM. Contribute to mereulab/scOMM development by creating an account on GitHub.

github.com

2 1 1

Elisabetta Mereu @elimereu.bsky.social · Mar 7

✅ Quantitative evaluation of integration strategies for sn/scRNA- and snATAC-seq.
✅ Identifying rare & clinically relevant cell types, including WFDC2+ thick ascending limb and Norn cells (EPO-producing fibroblasts).
✅ Enhancing kidney disease trait heritability analysis.
And last but not least..👇

1 1

Elisabetta Mereu @elimereu.bsky.social · Mar 7

Our preprint provides essential guidance on multimodal #singlecell data integration and human organ atlas generation, using the kidney as a model system. Key insights 👇:

1

Elisabetta Mereu @elimereu.bsky.social · Mar 7

🚀 New Preprint Alert! 🚀 With the Standards and Technology Working Group of the @humancellatlas.org, we present a new preprint guiding multimodal #singlecell data integration and human organ atlas generation! 📄
Read the preprint: www.biorxiv.org/content/10.1...

Systematic evaluation of single-cell multimodal data integration for comprehensive human reference atlas.

The integration of multimodal single-cell data enables comprehensive organ reference atlases, yet its impact remains largely unexplored, particularly in complex tissues. We generated a benchmarking da...

www.biorxiv.org

1 6 13

Reposted by Elisabetta Mereu

Josep Carreras Leukaemia Research Institute @carrerasijc.bsky.social · Feb 25

Today, 2 postdoctoral researchers from #CarrerasLeaders have led our Young Researcher Seminars🙌

🧑‍🔬👩‍🔬 Gerard Martínez (@scuartero.bsky.social lab) has presented his work on myeloid leukemia of Down syndrome and Alessia Buratin ( @elimereu.bsky.social lab) on machine learning to enhance CAR-T therapies

2 5

Elisabetta Mereu @elimereu.bsky.social · Feb 18

Could you add me please?

1 1