Holger Heyn
@hoheyn.bsky.social
350 followers
39 following
6 posts
Scientist. Single Cell Genomics Group Leader at CNAG. Co-founder & CSO at Omniscope. ICREA Professor.
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Reposted by Holger Heyn
CNAG
@cnag-eu.bsky.social
· Apr 3
Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes - Oncogene
Oncogene - Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes
www.nature.com
Reposted by Holger Heyn
CNAG
@cnag-eu.bsky.social
· Apr 4
Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer - Nature Communications
‘T cell engagers promote antitumor immunity, but how macrophage modulates this activity in tumor is still unclear. Here the authors show, using biopsies from patients with uveal melanoma and single ce...
www.nature.com
Reposted by Holger Heyn
Reposted by Holger Heyn
Holger Heyn
@hoheyn.bsky.social
· Mar 7
Systematic evaluation of single-cell multimodal data integration for comprehensive human reference atlas.
The integration of multimodal single-cell data enables comprehensive organ reference atlases, yet its impact remains largely unexplored, particularly in complex tissues. We generated a benchmarking da...
biorxiv.org
Reposted by Holger Heyn
Holger Heyn
@hoheyn.bsky.social
· Nov 29
Holger Heyn
@hoheyn.bsky.social
· Nov 29
Spatio-temporal T cell tracking for personalized TCR-T designs in childhood cancer
Immune checkpoint inhibition (ICI) has revolutionized oncology, offering extended survival and long-term remission in previously incurable cancers. While highly effective in tumors with high mutationa...
www.biorxiv.org
Holger Heyn
@hoheyn.bsky.social
· Nov 29
Adaptation in human immune cells residing in tissues at the frontline of infections - Nature Communications
Immune cells are under evolutionary pressure due to their anti-infective defence role. Here Salvador-Martínez and Murga-Moreno et al. combine population genetics approaches and Human Cell Atlas data, ...
www.nature.com