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Elizabeth Arkema @elizabetharkema.bsky.social · 10d

There has been a suggestion of a shared genetic risk between some cancers and sarcoidosis. This might explain the slightly increased risk of cancer associated with sarcoidosis that persists for years.

Elizabeth Arkema @elizabetharkema.bsky.social · 10d

We need a better evidence base for choosing treatments. If someone has a history of cancer, what treatment for sarcoidosis is best? Do sarcoidosis treatments increase cancer risk? We show that sarcoidosis, regardless of treatment is associated with cancer. How should people be screened?

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Elizabeth Arkema @elizabetharkema.bsky.social · 10d

Really enjoyed presenting my poster on malignancy risk associated with sarcoidosis. I got some great questions and comments from people - and now I have like 10 more study ideas 😂 first I need to finish this study! #ERS2025

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Elizabeth Arkema @elizabetharkema.bsky.social · 13d

“Don’t look for certainty in the science of uncertainty- it’s like looking for snow in the dessert” - Nicola Orsini ending his talk on statistical thinking in public health #episky

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Elizabeth Arkema @elizabetharkema.bsky.social · 13d

How to predict prolonged pregnancy outcomes, to identify who should be induced at week 41? When you introduce a new intervention, planning ahead and making time/space and having funding should be considered

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Elizabeth Arkema @elizabetharkema.bsky.social · 13d

We still need more data to build good prediction models - they are still not good enough (e.g. predicting vaginal birth after a first birth via cesarean )

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Elizabeth Arkema @elizabetharkema.bsky.social · 13d

In 2017 results from a randomized trial showed aspirin reduced preeclampsia risk in high risk pregnancies. First preventative medicine for PE
Now women in Sweden at high rusk are receiving aspirin during pregnancy www.nejm.org/doi/full/10....

Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia | NEJM

Preterm preeclampsia is an important cause of maternal and perinatal death and complications. It is uncertain whether the intake of low-dose aspirin during pregnancy reduces the risk of preterm pre...

www.nejm.org

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Elizabeth Arkema @elizabetharkema.bsky.social · 13d

A lot of effort has been put into predicting preeclampsia - using all the information we already collect, we can improve prediction.

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Elizabeth Arkema @elizabetharkema.bsky.social · 13d

Next: NIPT test - a blood sample which detects cell-free fetal DNA if KUB shows high risk. Now only 1% of pregnancies have amniocentesis.

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Elizabeth Arkema @elizabetharkema.bsky.social · 13d

Professor Olof Stephansson from Karolinska is our next speaker - we need precision medicine in obstetrics. One example: trisomy detection (Down’s syndrome). Initially only maternal age was used to identify pregnancies for amniocentesis. Then ultrasound was added and now KUB, improves accuracy.

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Elizabeth Arkema @elizabetharkema.bsky.social · 13d

We need to be more rigorous - need to test and validate in multiple cohorts. How do we take what we learn in academia into clinical care?

Elizabeth Arkema @elizabetharkema.bsky.social · 13d

He gave really good examples of identifying preclinical biomarkers in IBD. Signatures for treatment response did not pan out. Future: get longitudinal samples to capture dynamics. The heterogeneity of patients is a challenge.

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Elizabeth Arkema @elizabetharkema.bsky.social · 13d

Next presentation: Professor Jonas Halfvarsson from Örebro University on precision medicine in inflammatory bowel disease. They have developed diagnostic lipid and protein signatures

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Elizabeth Arkema @elizabetharkema.bsky.social · 13d

www.sciencedirect.com/science/arti...

Precision medicine for cardiometabolic disease: a framework for clinical translation

Cardiometabolic disease is a major threat to global health. Precision medicine has great potential to help to reduce the burden of this common and com…

www.sciencedirect.com

Elizabeth Arkema @elizabetharkema.bsky.social · 13d

A framework for clinical translation in precision medicine

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Elizabeth Arkema @elizabetharkema.bsky.social · 13d

An example: using unsupervised clustering to identify novel subgroups of diabetes. However the clusters identified were not clinically useful.

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Elizabeth Arkema @elizabetharkema.bsky.social · 13d

The next speaker is Professor Paul Franks from Lund University who explains why we need precision medicine for cardiometabolic diseases like diabetes. #episky

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Elizabeth Arkema @elizabetharkema.bsky.social · 13d

It takes 17 years for interventions to reach 14% of the populations. It takes a long time for them to be included in clinical guidelines- stakeholders should be involved earlier to make sure the interventions are acceptable

Elizabeth Arkema @elizabetharkema.bsky.social · 13d

There is a free online conference you can attend about precision public health in November #episky register here: events.humanitix.com/precision-pu...

Precision Public Health Transdisciplinary Conference 2025

This is a free virtual conference, funded by the National Institutes of Health and hosted by the Precision Public Health Network, The University of Technology.

events.humanitix.com

Elizabeth Arkema @elizabetharkema.bsky.social · 13d

Implementation science goes from pre-intervention, efficacy studies, effectiveness studies and implementation. It should be thought of earlier so that interventions can reach people quicker

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Elizabeth Arkema @elizabetharkema.bsky.social · 13d

We should do more investigation of the effectiveness of population public health interventions

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Elizabeth Arkema @elizabetharkema.bsky.social · 13d

There are opportunities in different areas to move forward with precision public health: capacity building, equity research, implementation science, data science & AI, ELSI research

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Elizabeth Arkema @elizabetharkema.bsky.social · 13d

First speaker of the day, Assistant Professor Megan Roberts from University of North Carolina explains what precision public health is: the right intervention at the right time to the right population. #episky

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Elizabeth Arkema @elizabetharkema.bsky.social · 13d

Strategic research in epidemiology day has started! @ki.se
The theme is precision medicine and we have a great line-up of speakers

Elizabeth Arkema @elizabetharkema.bsky.social · 16d

At a responsible internationalization seminar:
It is a national security risk to _not_ collaborate internationally - we will otherwise not understand eachother, and not have connections to experts in other countries.