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Reposted by Elliott Bernard

Broz Lab @brozlab.bsky.social · Feb 26

Registration opens soon for the second Pattern Recognition receptor symposium in Lausanne Switzerland in October 2025. Check out the link for the great list of speakers.

wp.unil.ch/immunobiolog...

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Reposted by Elliott Bernard

Rebsamen Lab @UNIL @rebsamenlab.bsky.social · Jan 28

We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland.

Registrations open March 1 - Attendance limited to 150 participants.

More info: wp.unil.ch/immunobiolog...

#ImmunoSky

Symposium immunobiology

wp.unil.ch

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Elliott Bernard @elliottbernard.bsky.social · Jan 28

#Pathogens #Lysosomes #CellDeath what's not to like? Check out our latest work deciphering how the protein NLRP6 links all of these to protect your gut from infections like Listeria.

Broz Lab @brozlab.bsky.social · Jan 28

Check out our latest pre print! Alexandra and colleagues show that the enigmatic inflammasome receptor, NLRP6 is activated by sterile and pathogen induced endolysosomal damage. Hot off the press!

www.biorxiv.org/content/10.1...

Sterile- or pathogen-induced endolysosomal damage activate the NLRP6 inflammasome in human intestinal epithelial cells

NLRP6 controls host defense against bacteria and viruses in the gastrointestinal tract by a poorly understood mechanism. Here, we report that NLRP6 forms an inflammasome upon endolysosomal damage caus...

www.biorxiv.org

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Elliott Bernard @elliottbernard.bsky.social · Dec 5

And for our latest insights into how NINJ1 is activated and forms membrane-rupturing filaments during cells death, check out our recent preprint.
www.biorxiv.org/content/10.1...

Ninjurin-1 mediated plasma membrane rupture is a two-step process requiring cell swelling

Plasma membrane rupture (PMR) and the release of cytosolic content are hallmarks of necrotic cell death. The plasma membrane protein ninjurin-1 (NINJ1) actively promotes cell lysis by polymerizing int...

www.biorxiv.org

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Elliott Bernard @elliottbernard.bsky.social · Dec 5

Interested in learning more about NINJ1? My colleagues in the @brozlab.bsky.social, including @ehartenian.bsky.social, wrote a nice review of our current knowledge. www.cell.com/trends/bioch...

www.cell.com

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Elliott Bernard @elliottbernard.bsky.social · Dec 5

New research revealed how NINJ1 is kept inactive in living cells. Head over to Nature News & Views to check out our thoughts on these cool findings. Free to read at rdcu.be/d2nqH

Broz Lab @brozlab.bsky.social · Dec 4

First real bluesky post 🥳 Did you know that NINJ1 exists as an autoinhibited dimer in the PM of cells? In a News & Views, @elliottbernard.bsky.social and Petr describe new results from Dixit & Deshpande, including a resting structure of NINJ1 with 3 helices! Check it out here: rdcu.be/d2nqH

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Elliott Bernard @elliottbernard.bsky.social · Nov 16

If you're interested in knowing what I'm currently working on in the lab, we recently posted a preprint of our findings www.biorxiv.org/content/10.1...

I study cell death and inflammation and am also interested in how cells defend themselves against infection.

Ninjurin-1 mediated plasma membrane rupture is a two-step process requiring cell swelling

Plasma membrane rupture (PMR) and the release of cytosolic content are hallmarks of necrotic cell death. The plasma membrane protein ninjurin-1 (NINJ1) actively promotes cell lysis by polymerizing int...

www.biorxiv.org

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