Please check out this exciting story that I was happy to contribute to alongside an amazing team. A huge thank you to our collaborators as well as @valendraica.bsky.social and Heather Folkwein for their training and guidance that prepared me for such an amazing project.

A wonderful collaboration between Jess Tyler lab, @epicypher.bsky.social, @gcloner.bsky.social, James Kadonaga and our lab at PSU. In this article, we provide the significance of the nucleosome acidic patch. 

doi.org/10.64898/202...

Our laboratory contributed to this work by resolving acidic patch-binding nanobodies developed by @epicypher.bsky.social. I’d like to thank our wonderful collaborators, and Emma Saccone (@emmasaccone.bsky.social)(data analysis, interprt., figs) and Heather Folkwein (@hjf3.bsky.social)(sample prep)

We did a thing... We purified native transcriptional complexes from Drosophila embryos, obtaining +/- stalk Pol II elongation complexes, native nucleosomes, as well as a nucleosome elongation complex. For more details please check out: doi.org/10.1101/2025...