Lightnews — Scholar-powered news

Central Precocious Puberty Elevates Psychiatric Disorder Risk

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 25

#CentralPrecociousPuberty elevated risk for #MentalDisorders as early as 1 year before diagnosis and up to 8 years after diagnosis.

@unidue.bsky.social @ruhr-uni-bochum.de

Central precocious puberty was associated with elevated risk for psychiatric disorders including depression, ADHD, and anxiety.

GLP-1RAs Better Reduce Amputation Risk Than SGLT2is in T2D

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 25

#Amputation risk was significantly reduced among patients with #T2D who used #GLP1RAs compared with #SGLT2is.

@dgarmstrong.bsky.social @keck.usc.edu @uscsurgery.bsky.social

GLP-1RAs were associated with significantly reduced risk for amputations relative to SGLT2is among patients with type 2 diabetes.

Endocrine Society Archives

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 24

Still catching up on research from #ENDO2025? Find all of Endocrinology Advisor's coverage from this month's conference below ⬇️ @endocrinesociety.bsky.social

Presenting research from ENDO, the annual meeting of the Endocrine Society.

SGLT2 Inhibitor Use Linked to Increased Risk for Erythrocytosis, Not Thrombosis

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 23

Relative to #GLP1RA and #DPP4i use, #SGLT2i use was associated with an increased risk for #erythrocytosis but not an increased risk for #thrombosis in #T2D.

SGLT2 inhibitor use was associated with an increased risk for erythrocytosis but not thrombosis among patients with type 2 diabetes.

Weight Loss-Induced Sex Hormone Changes May Affect BMD Loss in T2D

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 23

Changes in #BoneMineralDensity were mediated by changes in E2 and testosterone among women and men, respectively, with #T2D undergoing weight loss.

@erinmichos.bsky.social @johnshopkinssph.bsky.social @jhu.edu @imperialcollegeldn.bsky.social @uthsc.bsky.social

Weight loss-induced sex hormone changes had a mediating effect on bone mineral density loss among patients with type 2 diabetes.

Academic Detailing Plus Pre-Visit Handout Improves Diabetes Deprescribing

1 1

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 22

Pre-visit patient activation enhanced the positive effect of PCP academic detailing on diabetes #deprescribing rates among older adults with #T2D.

@kaiser-permanente.bsky.social @yaleschoolofmed.bsky.social

Academic detailing plus pre-visit patient activation was associated with sustained diabetes deprescribing rates at 12 months in older adults with T2D.

Linzagolix Sustains Reduced Menstrual Bleeding in Uterine Fibroids at 1 Year

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 22

Reduced heavy menstrual bleeding was sustained with #linzagolix therapy, regardless of adjunct hormonal add-back therapy, at 1 year among patients with #UterineFibroids.

@yaleschoolofmed.bsky.social @ox.ac.uk @goetheuni.bsky.social @ub.edu

Linzagolix therapy was associated with significantly reduced heavy menstrual bleeding by week 52 among patients with uterine fibroids.

Gestational Glucose Intolerance, Diabetes Influences Childhood Obesity

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 18

#Gestational #GlucoseIntolerance was associated with increased #obesity risk, especially among children aged 11 to 18 years.

@cepowemd.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social

Gestational glucose intolerance was associated with increased risk for obesity and overweight, especially among children aged 11 to 18 years.

Paltusotine Improves Patient-Reported Acromegaly Symptoms

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 17

From #ENDO2025: There are significant reductions in patient-reported symptom severity among patients with #acromegaly treated with paltusotine.

@endocrinesociety.bsky.social

Paltusotine treatment is associated with significant reductions in patient-reported symptom severity among patients with acromegaly.

Veligrotug Safe, Efficacious for Active TED

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 17

From #ENDO2025: Veligrotug vs placebo was associated with significant improvements in #proptosis, #diplopia, and clinical activity score in active #ThyroidEyeDisease.

@endocrinesociety.bsky.social @uwmedicine.bsky.social @bcmhouston.bsky.social @keck.usc.edu @stanfordmedicine.bsky.social

Veligrotug demonstrated significant improvements in proptosis, diplopia, and clinical activity score among patients with active thyroid eye disease.

Tirzepatide Cardiometabolic Benefits Greater in Women vs Men

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 17

From #ENDO2025: Among #tirzepatide users, women experienced greater reductions in total #cholesterol, LDL cholesterol, and weight than men.

@endocrinesociety.bsky.social @mayoclinic.org

Tirzepatide yielded greater cardiometabolic benefits, especially in total cholesterol, LDL cholesterol, and weight loss, among women than men.

Diazoxide Choline Extended-Release Safe for Hyperphagia in Prader-Willi Syndrome

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 17

From #ENDO2025: Diazoxide choline extended-release tablets for #hyperphagia demonstrated favorable #glycemic safety across 4 years among patients with #PraderWilliSyndrome

@endocrinesociety.bsky.social @nationwidekids.bsky.social @seattlechildrens.org

Diazoxide choline extended-release tablets demonstrated favorable safety profile across 4 years among patients with Prader-Willi Syndrome.

Adolescents With PCOS Show Modest Weight Loss After Bariatric Surgery

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 16

From #ENDO2025: #BariatricSurgery #WeightLoss outcomes were comparable between adolescent girls with and without #PCOS.

@endocrinesociety.bsky.social @nufeinbergmed.bsky.social @umnsph.bsky.social @tamu.bsky.social @cincychildrens.bsky.social @luriechildrens.bsky.social

Adolescents with PCOS demonstrated comparable weight loss to their reproductively normal peers after undergoing bariatric surgery.

Thyroid Cancer Burden Due to High BMI on the Rise in US

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 16

From #ENDO2025: #ThyroidCancer attributable to high #BMI increased from 1990 to 2021, especially among older adults and men.

@endocrinesociety.bsky.social

Thyroid cancer burden attributable to high BMI was increasing between 1990 and 2021 in the US, especially among men and older adults.

Adrenal Adenomas May Attenuate Weight Loss With Incretin-Based Therapy

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 16

From #ENDO2025: Presence of #adrenal #adenoma was associated with lower #WeightLoss among patients with #obesity using #GLP1 or GIP/GLP-1 receptor agonists.

@endocrinesociety.bsky.social

Adrenal adenomas were associated with attenuated weight loss among patients with obesity or overweight using GLP-1 or GIP/GLP-1 RAs.

Tirzepatide Superior to Semaglutide in T2D Therapy Targets

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 16

From #ENDO2025: #Tirzepatide was superior to #semaglutide in achieving standard and intensive #cardiometabolic targets among patients with #T2D.

@endocrinesociety.bsky.social

Tirzepatide was superior to semaglutide in achieving standard and intensive cardiometabolic targets among patients with type 2 diabetes.

Glucopilot Dynamic Dosing Algorithm for IV Insulin Therapy Improves Hypoglycemia

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 15

From #ENDO2025: Glucopilot dynamic dosing algorithm improved #glycemia management, especially among patients with #diabetic #ketoacidosis, #sepsis, and #steroid use.

@endocrinesociety.bsky.social @jhu.edu

Glucopilot dynamic dosing algorithm was associated with improved glycemic control especially among subgroups with hard-to-manage glycemia.

Crinecerfont Maintains A4, GC Reductions in Pediatric CAH at 1 Year

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 15

From #ENDO2025: In pediatric #CongenitalAdrenalHyperplasia, crinecerfont is associated with sustained reductions in androstenedione levels and #glucocorticoid doses at 1 year.

@endocrinesociety.bsky.social

Crinecerfont is associated with sustained reductions in androstenedione and GC doses at 1 year in congenital adrenal hyperplasia.

PCOS May Increase Vascular Event Risk in Thrombotic Disease

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 15

From #ENDO2025: Women with #thrombotic disease and comorbid #PCOS had higher rates of #vascular events and presented at a younger age than those with thrombotic disease and no PCOS.

@endocrinesociety.bsky.social

PCOS was associated with an increased risk for vascular events including stroke among women with thrombotic disease, and a lower mean age.

COCPs Improve Obesity Outcomes in Hyperandrogenic PCOS

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 15

From #ENDO2025: Although the addition of #metformin offered little benefit, combined #OralContraceptive pills were associated with improved #obesity outcomes in hyperandrogenic #PCOS.

@endocrinesociety.bsky.social @upenn.edu

COCPs were associated with improved obesity outcomes among patients with hyperandrogenic PCOS, but metformin added little benefit.

Hormone Therapy Plus Tirzepatide Enhances Postmenopausal Weight Loss

4

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 15

From #ENDO2025: #HormoneTherapy plus #tirzepatide was associated with greater #WeightLoss than tirzepatide among #postmenopausal women.

@endocrinesociety.bsky.social @mayoclinic.org

Hormone therapy as an adjunctive to tirzepatide was associated with greater weight loss than tirzepatide alone among postmenopausal women.

Osteoporosis Treatment After Fragility Fracture Lowers Mortality Risk

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 14

From #ENDO2025: #Osteoporosis treatment following fragility #Fracture was associated with significantly reduced #hospitalization and mortality risks among patients aged 80 years and older.

@endocrinesociety.bsky.social @clevelandclinic.bsky.social @upstatemedical.bsky.social

Osteoporosis treatment was associated with reduced hospitalization and mortality risks following fragility fracture after 80 years of age.

Setmelanotide Safe, Efficacious in Treating Acquired Hypothalamic Obesity

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 14

From #ENDO2025: #Setmelanotide was associated with significant #WeightReduction among adult and pediatric patients with acquired #HypothalamicObesity.

@endocrinesociety.bsky.social @ucsdhealth.bsky.social @themaximacenter.bsky.social @sickkidsto.bsky.social @childrensphila.bsky.social

Setmelanotide was associated with significant weight reduction among patients aged 4 years and older with acquired hypothalamic obesity.

Test Your Knowledge on Nutritional Support Strategies in GLP-1 Drug Use

Endocrinology Advisor @endocrinologyadv.bsky.social · Jul 11

Quiz Time! Test your knowledge on #nutritional support strategies in #GLP1 use. #EndoSky

Which of the statements about nutritional support strategies for patients using GLP-1 drugs are correct?