Erik Cumps
@erikcumps.bsky.social
Denk na. Kritisch denken is zelf denken en niet zomaar aannemen wat anderen denken.
That depends on the variant's degree of conservation of the antigen epitopes to which the neutralizing antibodies (nAbs) bind.
With lower conservation, i.e. more changes, current nAbs are less effective and a new immune challenge with updated antigen makes sense.
But still, remember nAbs wane.
With lower conservation, i.e. more changes, current nAbs are less effective and a new immune challenge with updated antigen makes sense.
But still, remember nAbs wane.
November 24, 2025 at 11:02 PM
That depends on the variant's degree of conservation of the antigen epitopes to which the neutralizing antibodies (nAbs) bind.
With lower conservation, i.e. more changes, current nAbs are less effective and a new immune challenge with updated antigen makes sense.
But still, remember nAbs wane.
With lower conservation, i.e. more changes, current nAbs are less effective and a new immune challenge with updated antigen makes sense.
But still, remember nAbs wane.
4) to crank up protection against infection, more neutralizing antibodies are needed.
5) to produce more antibodies, an immune challenge is needed. That means a (booster) vaccination, or an infection.
2/2
5) to produce more antibodies, an immune challenge is needed. That means a (booster) vaccination, or an infection.
2/2
November 24, 2025 at 10:00 PM
4) to crank up protection against infection, more neutralizing antibodies are needed.
5) to produce more antibodies, an immune challenge is needed. That means a (booster) vaccination, or an infection.
2/2
5) to produce more antibodies, an immune challenge is needed. That means a (booster) vaccination, or an infection.
2/2
That doesn't really matter.
As Marc explained:
1) preventing infection requires neutralizing antibodies.
2) antibodies always diminish over time (waning).
3) ergo, protection against infection also diminishes over time.
1/2
As Marc explained:
1) preventing infection requires neutralizing antibodies.
2) antibodies always diminish over time (waning).
3) ergo, protection against infection also diminishes over time.
1/2
November 24, 2025 at 9:53 PM
That doesn't really matter.
As Marc explained:
1) preventing infection requires neutralizing antibodies.
2) antibodies always diminish over time (waning).
3) ergo, protection against infection also diminishes over time.
1/2
As Marc explained:
1) preventing infection requires neutralizing antibodies.
2) antibodies always diminish over time (waning).
3) ergo, protection against infection also diminishes over time.
1/2