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ewaldlab.org
Jess Ewald
@ewaldlab.org
2K followers 1.8K following 21 posts
Computational biologist using omics data (imaging, gene expression) to investigate the impacts of environmental contaminants on biological systems Group Leader @EMBL-EBI (www.ewaldlab.org)
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ewaldlab.org
Jess Ewald @ewaldlab.org · Sep 3
It's been a great first few months at the EBI!
ebi.embl.org
EMBL-EBI @ebi.embl.org · Sep 3
Meet our newest Research Group Leader: Jess Ewald @ewaldlab.org ‬🇨🇦

Jess’s group takes a multi-disciplinary approach to identify and characterise chemical hazards to humans and ecosystems, using cell profiling data, machine learning, and integrative data analysis.

www.ebi.ac.uk/about/news/p...

🖥️🧬
Welcome: Jess Ewald
Jess Ewald, Research Group Leader at EMBL-EBI, uses cell profiling and AI to find and characterise chemical hazards to humans and ecosysystems.
www.ebi.ac.uk
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Reposted by Jess Ewald
niranjchandrasekaran.com
Niranj Chandrasekaran @niranjchandrasekaran.com · Aug 7
Morph Map is now published in Nature Methods. Excited to see what the community discovers with this resource mapping ~15,000 human genes!

rdcu.be/ezGre
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ewaldlab.org
Jess Ewald @ewaldlab.org · Aug 7
The visa is easy to obtain, for you and for any immediate family members. It allows a spouse to work in the UK.

Please reach out with any questions!
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ewaldlab.org
Jess Ewald @ewaldlab.org · Aug 7
Project 7: Predict cellular phenotypes induced by environmental contaminants based on compound structure and cellular images using generative AI, in collaboration with Mo Lotfollahi (www.sanger.ac.uk/group/lotfol...)
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ewaldlab.org
Jess Ewald @ewaldlab.org · Aug 7
Project 3: Decode morphological programmes of T cell activation through multimodal imaging and machine learning, in collaboration with @gosiatrynka.bsky.social (www.sanger.ac.uk/group/trynka...)
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ewaldlab.org
Jess Ewald @ewaldlab.org · Aug 7
Two of the projects are co-hosted by my lab (ewaldlab.org)
Ewald Lab
@ EMBL-EBI. We identify and characterize chemical hazards to both humans and ecosystems with cell profiling data, machine learning, and integrative data analysis.
ewaldlab.org
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ewaldlab.org
Jess Ewald @ewaldlab.org · Aug 7
Check out this opportunity to join my lab as a postdoc! www.ebi.ac.uk/research/pos...

Every year, faculty from EMBL-EBI and the Wellcome Sanger Institute co-develop projects that allow fellows to be part of ✨both✨ of these amazing research institutes.
EMBL-EBI-Sanger postdoctoral fellowships (ESPOD)
The ESPOD fellowship builds on the collaborative relationship between EMBL-EBI and the Wellcome Sanger Institute, offering projects that combine experimental (wet-lab) and computational (dry-lab) appr...
www.ebi.ac.uk
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ewaldlab.org
Jess Ewald @ewaldlab.org · Mar 31
Two days left before the application closes!
ewaldlab.org
Jess Ewald @ewaldlab.org · Mar 5
🚨 We're hiring! 🚨 The Ewald Lab at EMBL-EBI is looking for a postdoctoral researcher in multi-omics, machine learning, and predictive toxicology to analyze a groundbreaking toxicology dataset as part of the OASIS Consortium.

More details & application here: lnkd.in/eHD7DMdX
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Reposted by Jess Ewald
bethcimini.bsky.social
Beth Cimini 🔬💻📊 @bethcimini.bsky.social · Mar 7
We're once again hiring a summer (+?) #bioimage #bioimageanalysis #software intern! Due to requirements of the funding program, you must be a current student, as well as work onsite in MA (+ have US work permission). Details at the link below. Spend your summer making great tools with fun people!
Software engineering intern - summer/fall 2025 - Cambridge, MA USA
If you are a current student (undergraduate/masters/PhD) with permission to work in the US and ability to work in-person in Cambridge, MA, US, consider a summer internship in the Broad Institute Imagi...
forum.image.sc
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ewaldlab.org
Jess Ewald @ewaldlab.org · Mar 6
Two EMBL-specific quirks:
- EMBL salaries are "after tax", so the stated salary is roughly equivalent to $70k USD
- Employees qualify for a quick & inexpensive visa exemption that allows them and their spouse/children to work in the UK (my visa was processed in 2 days and cost me $50USD)
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ewaldlab.org
Jess Ewald @ewaldlab.org · Mar 5
🚨 We're hiring! 🚨 The Ewald Lab at EMBL-EBI is looking for a postdoctoral researcher in multi-omics, machine learning, and predictive toxicology to analyze a groundbreaking toxicology dataset as part of the OASIS Consortium.

More details & application here: lnkd.in/eHD7DMdX
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Reposted by Jess Ewald
bcellorg.bsky.social
Patrick MacDonald🇨🇦 @bcellorg.bsky.social · Feb 21
We link molecular and functional phenotypes of islet cells from donors with type 1 diabetes to understand impaired insulin and glucagon secretion. Immune signalling, nuclear exclusion, mTOR and lysosomes in alpha cell dysfunction.

https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1
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ewaldlab.org
Jess Ewald @ewaldlab.org · Feb 3
6/ Huge thank you to my co-authors at Axiom who were wonderful to work with, as well as to the entire OASIS Consortium.
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ewaldlab.org
Jess Ewald @ewaldlab.org · Feb 3
5/ These findings demonstrate the potential of image-based profiling as a sensitive, animal-free, early-stage screening tool for compound toxicity.
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ewaldlab.org
Jess Ewald @ewaldlab.org · Feb 3
4/ We found that the morphological profiles detect compound bioactivity at lower concentrations than standard cytotoxicity assays. In supervised analyses, they predict cytotoxicity and targeted cell-based assay readouts, but not cell-free assay readouts.
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ewaldlab.org
Jess Ewald @ewaldlab.org · Feb 3
3/ We then use supervised machine learning to predict diverse in vitro assay readouts relevant to mode-of-action and cell state using image-based profiles. We also investigate optimal strategies for extracting information from images to make mode-of-action predictions.
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ewaldlab.org
Jess Ewald @ewaldlab.org · Feb 3
2/ High-throughput, human-relevant approaches for predicting chemical toxicity are urgently needed.

In our new preprint, we use Cell Painting and cytotoxicity assays to profile >1000 compounds in primary human hepatocytes, including pharmaceuticals, pesticides, and industrial chemicals.
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ewaldlab.org
Jess Ewald @ewaldlab.org · Feb 3
First large-scale analysis of chemical toxicity in primary human hepatocytes!

www.biorxiv.org/content/10.1...
Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes
High-throughput, human-relevant approaches for predicting chemical toxicity are urgently needed for better decision-making in human health. Here, we apply image-based profiling (the Cell Painting assa...
www.biorxiv.org
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Reposted by Jess Ewald
drannecarpenter.bsky.social
Anne Carpenter @drannecarpenter.bsky.social · Dec 18
We've a postdoc opening for our lab at the Broad: Cambridge MA!

Must have experience in toxicology + data science

Work on the wonderful OASIS dataset we are producing... Cell Painting, transcriptomics, proteomics in various liver cell and tissue models!

broad.io/mlcbpostdoc
Image of the job posting (see URL for full text instead)
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Reposted by Jess Ewald
bethcimini.bsky.social
Beth Cimini 🔬💻📊 @bethcimini.bsky.social · Dec 16
New Year, new job? Delighted to announce two early-career-level (post-BA/BS or MA) positions in my lab, and an open call for computational postdocs at the Broad!

First, an image analysis associate - work on high content screens for all kinds of cells and dimensionalities! See more at link (1/4)
Image analysis associate job description
Image Analysis Associate Broad Institute of MIT and Harvard, Cambridge, MA Impact the discovery of new disease therapies in the Cimini laboratory at the Imaging Platform Join our vibrant, world-clas...
docs.google.com
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ewaldlab.org
Jess Ewald @ewaldlab.org · Dec 15
Thanks, I'll try make it out! This is right after I move.
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ewaldlab.org
Jess Ewald @ewaldlab.org · Dec 13
I think about macromolecules a lot, but mainly as either targets of small molecules that cause target-mediated toxicity, or as something that we can measure at scale (omics data) to detect toxicity.
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ewaldlab.org
Jess Ewald @ewaldlab.org · Dec 13
Thanks! Looking forward to starting!
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ewaldlab.org
Jess Ewald @ewaldlab.org · Dec 13
🎉 I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) 🎉

We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.

I am beginning the search for two postdocs now - stay tuned for more details!

ewaldlab.org
Ewald Lab
@ EMBL-EBI. We identify and characterize chemical hazards to both humans and ecosystems with cell profiling data, machine learning, and integrative data analysis.
ewaldlab.org
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Reposted by Jess Ewald
johnarevalo.bsky.social
John Arevalo @johnarevalo.bsky.social · Dec 13
Excited to present our spotlight paper at #NeurIPS!

MOTIVE is a new dataset + benchmark for predicting drug-target interactions, using Cell Painting data

Location: Fri 13 Dec 4:30 p.m. PST @ East Exhibit Hall A-C #4208
Poster: neurips.cc/virtual/2024...
Paper: arxiv.org/abs/2406.08649
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