Ezequiel Ruiz-Mateos Carmona
@ezequielruizmateos.bsky.social
Científico Titular del CSIC. Instituto de Biomedicina de Sevilla (IBiS).
Scientist of the Spanish National Research Council (CSIC). Institute of Biomedicine of Seville (IBiS). Spain.
De Rota (Cádiz).
From Rota (Cádiz).
Scientist of the Spanish National Research Council (CSIC). Institute of Biomedicine of Seville (IBiS). Spain.
De Rota (Cádiz).
From Rota (Cádiz).
4/4
Our findings reveal a cooperative network between pDCs, CD141+ mDCs, and CD8+ T cells in lymphoid tissue during HIV infection.
This crosstalk may boost immune control of HIV and supports DC-based immunotherapies as a promising strategy.
#HIV #Immunotherapy #DCresearch
Our findings reveal a cooperative network between pDCs, CD141+ mDCs, and CD8+ T cells in lymphoid tissue during HIV infection.
This crosstalk may boost immune control of HIV and supports DC-based immunotherapies as a promising strategy.
#HIV #Immunotherapy #DCresearch
October 1, 2025 at 11:50 AM
4/4
Our findings reveal a cooperative network between pDCs, CD141+ mDCs, and CD8+ T cells in lymphoid tissue during HIV infection.
This crosstalk may boost immune control of HIV and supports DC-based immunotherapies as a promising strategy.
#HIV #Immunotherapy #DCresearch
Our findings reveal a cooperative network between pDCs, CD141+ mDCs, and CD8+ T cells in lymphoid tissue during HIV infection.
This crosstalk may boost immune control of HIV and supports DC-based immunotherapies as a promising strategy.
#HIV #Immunotherapy #DCresearch
3/4
When we co-cultured TLR-primed pDCs and CD141+ mDCs with CD8+ T cells, we observed stronger and more polyfunctional responses to both superantigens and HIV.
Blocking PD-1 with pembrolizumab enhanced these responses even further.
When we co-cultured TLR-primed pDCs and CD141+ mDCs with CD8+ T cells, we observed stronger and more polyfunctional responses to both superantigens and HIV.
Blocking PD-1 with pembrolizumab enhanced these responses even further.
October 1, 2025 at 11:50 AM
3/4
When we co-cultured TLR-primed pDCs and CD141+ mDCs with CD8+ T cells, we observed stronger and more polyfunctional responses to both superantigens and HIV.
Blocking PD-1 with pembrolizumab enhanced these responses even further.
When we co-cultured TLR-primed pDCs and CD141+ mDCs with CD8+ T cells, we observed stronger and more polyfunctional responses to both superantigens and HIV.
Blocking PD-1 with pembrolizumab enhanced these responses even further.
2/4
In lymph nodes from people living with HIV, we found that pDCs and CD141+ mDCs physically interact with CD8+ T cells — and that these interactions correlate with HIV levels in both blood and tissue.
This suggests a direct role in viral control.
In lymph nodes from people living with HIV, we found that pDCs and CD141+ mDCs physically interact with CD8+ T cells — and that these interactions correlate with HIV levels in both blood and tissue.
This suggests a direct role in viral control.
October 1, 2025 at 11:49 AM
2/4
In lymph nodes from people living with HIV, we found that pDCs and CD141+ mDCs physically interact with CD8+ T cells — and that these interactions correlate with HIV levels in both blood and tissue.
This suggests a direct role in viral control.
In lymph nodes from people living with HIV, we found that pDCs and CD141+ mDCs physically interact with CD8+ T cells — and that these interactions correlate with HIV levels in both blood and tissue.
This suggests a direct role in viral control.
1/4
Using flow cytometry, we suspected an interaction among plasmacytoid dendritic cells (pDCs), CD141+ myeloid DCs (mDCs), and CD8+ T cells — and that the PD-1/PD-L1 axis played a key role in antiviral function.
So we turned to the tissue morphology for answers.
Using flow cytometry, we suspected an interaction among plasmacytoid dendritic cells (pDCs), CD141+ myeloid DCs (mDCs), and CD8+ T cells — and that the PD-1/PD-L1 axis played a key role in antiviral function.
So we turned to the tissue morphology for answers.
October 1, 2025 at 11:49 AM
1/4
Using flow cytometry, we suspected an interaction among plasmacytoid dendritic cells (pDCs), CD141+ myeloid DCs (mDCs), and CD8+ T cells — and that the PD-1/PD-L1 axis played a key role in antiviral function.
So we turned to the tissue morphology for answers.
Using flow cytometry, we suspected an interaction among plasmacytoid dendritic cells (pDCs), CD141+ myeloid DCs (mDCs), and CD8+ T cells — and that the PD-1/PD-L1 axis played a key role in antiviral function.
So we turned to the tissue morphology for answers.