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fabiololicato.com
Fabio Lolicato
@fabiololicato.com
1.1K followers 480 following 35 posts
Group Leader at the Heidelberg University Biochemistry Center (BZH) A computational physicist lost into a biochemistry Lab. Find me on Mastodon: @[email protected] https://fabiololicato.com
fabiololicato.com
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Reposted by Fabio Lolicato
dimovalab.bsky.social
Dimova Lab @dimovalab.bsky.social · 5d
🎉 Congratulations to the winners of the Best Poster Awards at #BiomembraneDays2025 sponsored by @lipotype.bsky.social

🏆Manpreet Kaur (with @fabiololicato.com &W. Nickel)
🏆Jana Kroll (@janakroll.bsky.social @mdc-berlin.bsky.social)
🏆Ha Ngoc Anh Nguyen (with @jamessaenz.bsky.social)

🚀Science rocks!
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Reposted by Fabio Lolicato
dgfb.bsky.social
Deutsche Gesellschaft für Biophysik e.V. (DGfB) @dgfb.bsky.social · 13d
❗Hello Bluesky World❗

🚀 Excited to share that the German Biophysics Society (DGfB) is now on social!
We bring together scientists at the interface of physics, chemistry & biology!

Stay tuned for news, events & meetings! ✨
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Reposted by Fabio Lolicato
plantophagy.bsky.social
Yasin Dagdas @plantophagy.bsky.social · 16d
Now @bzh-hd.bsky.social Jonathan Friedman is talking in #mitochondria organization
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fabiololicato.com
Fabio Lolicato @fabiololicato.com · 22d
@bzh-hd.bsky.social @uniheidelberg.bsky.social @sfb1638.bsky.social @manpreet0700.bsky.social @walter-nickel-bzh.bsky.social
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fabiololicato.com
Fabio Lolicato @fabiololicato.com · 22d
🚨 Preprint Alert 🚨 #LipidTime

Excited to share our new preprint! 🎉 We propose a hypothesis for how FGF2 crosses the plasma membrane — a mechanism that may reflect a general principle of membrane remodeling.

🔑 Key idea: Non-bilayer lipid accumulation alters membrane properties, driving remodeling.
biorxivpreprint.bsky.social
bioRxivpreprint @biorxivpreprint.bsky.social · 22d
Nanoscale PI(4,5)P2 partitioning driven by FGF2 oligomerization triggers membrane pore formation https://www.biorxiv.org/content/10.1101/2025.09.11.675533v1
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fabiololicato.com
Fabio Lolicato @fabiololicato.com · Aug 22
Thrilled to have contributed to this amazing work! Thanks for having us on board 🙌 Huge shoutout to our super-talented postdoc #MelanieKönig for her outstanding efforts 💫. And big congratulations to everyone involved in this terrific team effort! 🎉 @sfb1638.bsky.social @bzh-hd.bsky.social
pfeffercryolab.bsky.social
PfefferCryoLab @pfeffercryolab.bsky.social · Aug 22
We are excited to share our latest work elucidating the structural basis for how augmin binds to microtubules. Out just now @natcomms.nature.com :

www.nature.com/articles/s41...
Conserved function of the HAUS6 calponin homology domain in anchoring augmin for microtubule branching - Nature Communications
Augmin is essential for microtubule nucleation during cell division. This study reveals how the conserved calponin homology domain of the augmin subunit HAUS6 binds to microtubules to orient augmin fo...
www.nature.com
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fabiololicato.com
Fabio Lolicato @fabiololicato.com · Jul 21
Too generous :) Thanks!
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fabiololicato.com
Fabio Lolicato @fabiololicato.com · Jul 21
A bit late—but better late than never!
Honored to present my work at #EBSA2025 in Rome a few weeks ago.

I first attended EBSA in 2017 in Edinburgh and haven’t missed one since. This year in Rome—my first home—was especially meaningful. 🇮🇹

Already looking forward to Berlin 2027—my new home! 🇩🇪
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Reposted by Fabio Lolicato
bzh-hd.bsky.social
Heidelberg University Biochemistry Center @bzh-hd.bsky.social · Jul 21
Looking for a PhD position?

The Schuck lab has an opening for a student interested in finding out how human cells control the size of their endoplasmic reticulum. Please visit www.bzh.uni-heidelberg.de/schuck and navigate to 'Open Positions'.
Universit�t Heidelberg - BZH
www.bzh.uni-heidelberg.de
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Reposted by Fabio Lolicato
bzh-hd.bsky.social
Heidelberg University Biochemistry Center @bzh-hd.bsky.social · May 27
Do you want to become our colleague?

We are looking to fill a part-time (50%) permanent position for a Technical Laboratory Assistant, starting September 15, 2025.

See below for further details on the role and responsibilities

👇👇👇👇👇👇👇👇👇👇👇👇👇👇👇👇👇👇👇👇👇
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fabiololicato.com
Fabio Lolicato @fabiololicato.com · May 22
It was an honor and a real pleasure to be the first speaker at the inaugural @bitsinbio.bsky.social meetup in Berlin!A fantastic opportunity to share my past work and future research directions with such an inspiring and engaged audience!

Huge thanks to @instadeep.bsky.social for making it happen!
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Reposted by Fabio Lolicato
sfb1638.bsky.social
SFB1638 @sfb1638.bsky.social · May 16
Just back from the Jacques Monod Conference on Membrane Remodeling in Roscoff—an inspiring trip for Sebastian Schuck and Michael Meinecke (@meineckelab)! We had exciting science, engaged in inspiring discussions, and enjoyed the stunning setting. There’s nothing quite like membrane research.
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fabiololicato.com
Fabio Lolicato @fabiololicato.com · May 7
If you’re in vibrant Berlin next Friday, May 16, come to visit me!

I’ll be giving a talk on how computer simulations help us understand lipid-driven membrane remodeling events!

Plus, word has it there will be pizza and drinks after the talks! 🍕🍻

👇👇👇👇👇👇👇

lu.ma/gcrpy5fg
Chips & Cells: Advancing discoveries in cell membrane biology through AI & physics-based computational methods · Luma
Join us for the inaugural Bits in Bio meetup in Berlin! ✨ We’re bringing together curious minds at the intersection of biology, software, and big data —…
lu.ma
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Reposted by Fabio Lolicato
bzh-hd.bsky.social
Heidelberg University Biochemistry Center @bzh-hd.bsky.social · Apr 28
The Schuck lab is looking for a PhD student or postdoc who is keen to understand how cells control organelle size and shape.

For more information, please visit www.bzh.uni-heidelberg.de/schuck and have a look at 'open positions’.
Universität Heidelberg - BZH
Diese Seite verwendet Frames. Frames werden von Ihrem Browser aber nicht unterstützt. Gehen Sie direkt zu https://bzh.db-engine.de/group/80/sebastian%20schuck
www.bzh.uni-heidelberg.de
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fabiololicato.com
Fabio Lolicato @fabiololicato.com · Apr 21
This work is the result of a shared @dfg.de grant between @walter-nickel-bzh.bsky.social and me, carried out by our joint PhD student @manpreet0700.bsky.social at @uniheidelberg.bsky.social @bzh-hd.bsky.social . A great team effort! 🙌
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fabiololicato.com
Fabio Lolicato @fabiololicato.com · Apr 21
FGF2 secretion depends on PI(4,5)P₂ asymmetry across the plasma membrane. Disrupting this asymmetry with exogenous PI(4,5)P₂ blocks FGF2 translocation—an effect that reverses as cells restore asymmetry over time
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fabiololicato.com
Fabio Lolicato @fabiololicato.com · Apr 21
To quantify FGF2 translocation kinetics, we developed a new single-cell confocal assay. Following doxycycline induction, we removed surface FGF2-GFP with heparin wash and tracked its rapid reappearance—capturing a fresh wave of secretion at different incubation times
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fabiololicato.com
Fabio Lolicato @fabiololicato.com · Apr 21
If our hypothesis holds, disrupting PI(4,5)P₂ asymmetry in cells should slow FGF2 translocation. To test this, @manpreet0700.bsky.social introduced PI(4,5)P₂ micelles in the media—enriching the outer leaflet and disturbing the natural asymmetry. And yes, it made a difference.
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fabiololicato.com
Fabio Lolicato @fabiololicato.com · Apr 21
Cells vs. reconstitution systems: Asymmetric PI(4,5)P₂ distribution in living cells accelerates FGF2 translocation—something symmetric GUVs can’t replicate. But when we enzymatically introduced asymmetry into GUVs, the magic finally happened 🪄🎩🐇
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Fabio Lolicato @fabiololicato.com · Apr 21
FGF2 translocates in 200ms in cells—but takes ~1hr in reconstitution systems. What drives this rapid kinetics in cells? 🏃‍♂️⏩⏩
Many auxiliary factors are missing in reconstituted systems. We pinpoint transbilayer PI(4,5)P₂ asymmetry as a key contributor to efficient membrane translocation.
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fabiololicato.com
Fabio Lolicato @fabiololicato.com · Apr 21
🚨 Lipid Time! 🚨
Excited to share our latest story now on @biorxiv-biochem.bsky.social !
Our brilliant PhD student @manpreet0700.bsky.social , together with @walter-nickel-bzh.bsky.social and myself, shows how PI(4,5)P₂ asymmetry in the plasma membrane drives the unconventional secretion of FGF2!
👇👇👇
Plasma membrane transbilayer asymmetry of PI(4,5)P2 drives unconventional secretion of Fibroblast Growth Factor 2
Unconventional secretion of Fibroblast Growth Factor 2 (FGF2) is based upon direct self-translocation across the plasma membrane, a process that involves the transient formation of a lipidic membrane ...
www.biorxiv.org
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Reposted by Fabio Lolicato
labvanni.bsky.social
Vanni Lab at UNIFR, Switzerland @labvanni.bsky.social · Apr 15
Our lab is hiring 1 PhD and 1 Postdoc to study the mechanism of lipid transport using computational methods (Molecular Dynamics, AI). Fully funded by @snsf-ch.bsky.social for 4 years, with amazing collaborators and excellent life and working conditions. Apply by email. Please share and repost!
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Reposted by Fabio Lolicato
sfb1638.bsky.social
SFB1638 @sfb1638.bsky.social · Apr 11
Hello Science World,
Our SFB1638 is now on bluesky. We study cellular membrane remodelling pathways.
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fabiololicato.com
Fabio Lolicato @fabiololicato.com · Apr 11
🚨Lipid Time🚨 Proud to be part of this amazing consortium focus on membrane remodeling!! 🔬Excited to contribute as a key computer simulations hub 🧑‍💻 connecting and supporting all the projects in this collaborative effort! 💪
#SFB1638 @uniheidelberg.bsky.social @bzh-hd.bsky.social
sfb1638.bsky.social
SFB1638 @sfb1638.bsky.social · Apr 11
Wrapped up our first Spring School — such a fun and inspiring event! Amazing science, great people, perfect weather and lots of good vibes all around. Already looking forward to the next one.
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Reposted by Fabio Lolicato
sfb1638.bsky.social
SFB1638 @sfb1638.bsky.social · Apr 11
Wrapped up our first Spring School — such a fun and inspiring event! Amazing science, great people, perfect weather and lots of good vibes all around. Already looking forward to the next one.
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