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A diverse and distinct microbiome inside living trees - Nature

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Frederickson D. Entila, PhD @fdentila.bsky.social · Aug 15

functional overlap among organ microbiota doesn’t seem to apply for trees as what we usually see in other relatively smaller plants; the internal tissues of trees are so anoxic, nutritionally restrictive, and antimicrobial-rich analogous to mammalian stomach…

www.nature.com/articles/s41...

Microbiome analyses of living trees show that a single tree can host approximately one trillion bacteria, with microbial communities distinctly partitioned between heartwood and sapwood and with minim...

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Frederickson D. Entila, PhD @fdentila.bsky.social · Jul 30

also cancer cells steal mitochondria from neurons to fuel its metastasis

www.nature.com/articles/s41...

Neural anticipation of virtual infection triggers an immune response - Nature Neuroscience

Frederickson D. Entila, PhD @fdentila.bsky.social · Jul 30

I wonder how physiological responses of people working in hospital settings are impacted since seeing sick people is customary…

Frederickson D. Entila, PhD @fdentila.bsky.social · Jul 30

even the sight of sick people elicits immune responses as an anticipation for a possible infection…

www.nature.com/articles/s41...

Serino et al. show that seeing an infectious avatar approach the body in virtual reality triggers an immune response, indicating that the brain prepares the body to fight infections even for perceived...

Apoplastic barriers are essential for nodule formation and nitrogen fixation in Lotus japonicus

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Reposted by Frederickson D. Entila, PhD

Stéphane Hacquard @hacquardst.bsky.social · Apr 10

We present MetaFlowTrain, an easy-to-build, highly parallelized, and cost-effective fluidic system for studying microbial exometabolites and their roles in modulating microbe–microbe–host interactions. Kudos to @chesneau-g.bsky.social @mpipz.bsky.social
Give it a try: www.nature.com/articles/s41...

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Reposted by Frederickson D. Entila, PhD

Tonni Andersen @tonnigrubeandersen.bsky.social · Mar 21

Finally!
Im so excited to present to culmination of many years of work from the fantastic Defeng Shen and some great collaborators. For details, I have made a digested thread below, but if you are more interested feel free to reach out (and read the paper of course).
www.science.org/doi/10.1126/...

Establishment of the apoplastic root barrier known as the Casparian strip occurs early in root development. In legumes, this area overlaps with nitrogen-fixing nodule formation, which raises the possi...

Perception of viral infections and initiation of antiviral defence in rice - Nature

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Frederickson D. Entila, PhD @fdentila.bsky.social · Mar 18

viral coat protein is perceived by RBRL, enhancing its ligase activity to ubiquitinate NINJA3 for degradation leading to de-repression of JA signalling for antiviral defense in rice

www.nature.com/articles/s41...

Viral coat proteins are perceived by the RING1–IBR–RING2-type ubiquitin ligase, initiating the first step of the natural antiviral response in rice.

Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota - Nature Plants

Frederickson D. Entila, PhD @fdentila.bsky.social · Mar 14

immune-modulation of host plants is requisite for terrestrial predominance of Xanthomonodales strains

www.nature.com/articles/s41...

The authors show that immunosuppression is highly conserved in the bacterial order Xanthomonadales. This feature, which preceded their specialization as host-adapted pathogens, probably contributes to...

A travelling-wave strategy for plant–fungal trade - Nature

Frederickson D. Entila, PhD @fdentila.bsky.social · Feb 26

the mycorrhizal highways moves in waves with trade interests at the forefront flowing dynamically in both ways within hyphae.

www.nature.com/articles/s41...

Symbiotic fungi control network-level structure and flows to meet trade demands.

The gut microbiota reprograms intestinal lipid metabolism through long noncoding RNA Snhg9

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Frederickson D. Entila, PhD @fdentila.bsky.social · Feb 12

www.science.org/doi/10.1126/...
gut microbiota represses lncRNA Snhg9 expression in the intestine to reconfigure lipid metabolism abetting diet-induced obesity in mice.

The intestinal microbiota promotes lipid absorption and storage by repressing the expression of the long noncoding RNA gene Snhg9.

Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature

Frederickson D. Entila, PhD @fdentila.bsky.social · Jan 25

cancer cells transfer ROS-resistant defective mitochondria to immune cells rendering it dysfunctional, senescent, and memory deficient to evade immunity…

www.nature.com/articles/s41...

Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

Creating coveted bioluminescence colors for simultaneous multi-color bioimaging

Frederickson D. Entila, PhD @fdentila.bsky.social · Jan 25

expanded bioluminescence spectrum for simultaneous imaging of cellular processes, even with just a smartphone

www.science.org/doi/10.1126/...

Twenty-color bioluminescent proteins have been developed for simultaneous imaging of multiple biological targets.

Streptomyces secretes a siderophore that sensitizes competitor bacteria to phage infection - Nature Microbiology

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Frederickson D. Entila, PhD @fdentila.bsky.social · Jan 18

The siderophore coelichelin from Streptomyces sp. sensitizes the competitor Bacillus subtilis to phage predation via iron-sequestration resulting to inhibition of Spo0A activation.

www.nature.com/articles/s41...

A secondary metabolite sensitizes competitor Bacillus subtilis to a wide panel of lytic phages by sequestering iron and preventing the activation of Spo0A.

Siderophore synthetase-receptor gene coevolution reveals habitat- and pathogen-specific bacterial iron interaction networks

Frederickson D. Entila, PhD @fdentila.bsky.social · Jan 16

sequence-to-ecology study of Pseudomonas siderophores reveal microbial iron heist: non-pathogenic strains are iron altruists while pathogenic strains are selfish iron hoarders.

www.science.org/doi/10.1126/...

Coevolving siderophore genes shape bacterial iron networks, unveiling the complexity of cheating across habitats and lifestyles.

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Reposted by Frederickson D. Entila, PhD

Tatsuya Nobori @tatsuyanobori.bsky.social · Jan 8

New year, new paper! Now published in @nature.com. We identified and characterised diverse immune cell states in plants under pathogen attack. My postdoc work in the Ecker lab at @salkinstitute.bsky.social. A thread (0/n)
#PlantScience
www.nature.com/articles/s41...

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Frederickson D. Entila, PhD @fdentila.bsky.social · Dec 29

Can I join too?