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The FEBS Journal @febsj.bsky.social · 2d

📗 The CRISPR-Cas9 knockout DDC SH-SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross-sectional structural and functional analysis

Read the article from our Disease Mechanisms focus issue ➡️ febs.onlinelibrary.wiley.com/doi/10.1111/...

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The FEBS Journal @febsj.bsky.social · 4d

We are pleased to spotlight a new #OA article from our Disease Mechanisms focus issue

🧠 Allosteric modulation of protein kinase A in individuals affected by NLPD-PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

Read here ➡️
febs.onlinelibrary.wiley.com/doi/10.1111/...

FEBS Press

In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism dr...

febs.onlinelibrary.wiley.com

Reposted by The FEBS Journal

Ryo Yokoyama @yokoyama-ryo.bsky.social · 9d

Phylogenetic reconciliation provides new insights into the evolutionary diversification of the glutamine synthetase gene family in seed plants febs.onlinelibrary.wiley.com/doi/10.1111/... @febsj.bsky.social

FEBS Press

Phylogenetic analyses of glutamine synthetase (GS) in seed plants revealed that all three major evolutionary lineages (GS2, GS1a, and GS1b) must have been present in the common ancestor, with GS2 bei....

febs.onlinelibrary.wiley.com

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The FEBS Journal @febsj.bsky.social · 9d

We are proud to share this new State-of-the-Art-Review from our recent Structural Insights into Disease Mechanisms focus issue 🪰🧪

📗 In vivo and in silico models of #drosophila for #parkinsonsdisease

Read the review #openaccess here ➡️ febs.onlinelibrary.wiley.com/doi/10.1111/...

Reposted by The FEBS Journal

Cristina Muñoz Pinedo @crismunozp.bsky.social · 10d

Excellent review in the FEBS Journal (@febsj.bsky.social)
"Emerging roles for integrated stress response signaling in homeostasis"
Shyama Nandakumar, Lydia Grmai, Deepika Vasudevan
febs.onlinelibrary.wiley.com/doi/full/10....

FEBS Press

Integrated stress response (ISR), an evolutionarily conserved eukaryotic stress-adaptive program in eukaryotes, has also been implicated in homeostatic functions. This review covers a broad body of l...

febs.onlinelibrary.wiley.com

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Anna-Karin Gustavsson @gustavssonlab.bsky.social · 10d

Excited that our work led by the Dere Lab is now published! This study is the first to identify KDM4A as a centrosome protein, revealing its chromatin-independent function in maintaining centrosome integrity and genomic stability!
#microscopy #nanoscale @febsj.bsky.social
doi.org/10.1111/febs...

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The FEBS Journal @febsj.bsky.social · 11d

🩺 Małgorzata Kosla and her husband Piotr established the PACS2 Research Foundation when their daughter was diagnosed with this ultrarare syndrome.

Read the interview with FEBSJ Editor @hajrah-khawaja.bsky.social and Malgorzata Kosla, here ➡️ febs.onlinelibrary.wiley.com/doi/10.1111/...

FEBS Press

In this issue of The FEBS Journal, we interviewed Małgorzata ‘Gosia’ Kosla, who together with her husband Piotr, established the PACS2 Research Foundation when their daughter Lena was diagnosed with ...

febs.onlinelibrary.wiley.com

The FEBS Journal @febsj.bsky.social · 15d

Our Disease Mechanisms Focus Issue is out now 📗🪰 febs.onlinelibrary.wiley.com/toc/17424658...

Articles combine fundamental structural insight with mechanistic implications for disease, reinforcing how structural information is essential for unravelling the basis and guiding therapeutic strategies.

Reposted by The FEBS Journal

HaitinLab @haitinlab.bsky.social · Jul 7

Excited to share our new paper in @febsj.bsky.social! 🎉
We show how a #MYELOMA-linked GGPPS mutation tweaks hexamerization, substrate binding and product inhibition, revealing an unexpected layer of protein prenylation regulation
🔗 doi.org/10.1111/febs...
@peterslab1.bsky.social

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Peter Mace @petermace.bsky.social · Jul 29

Excited to see this work led by Cameron Reddington and Annabel Walsh out in @febsj.bsky.social — ASXL proteins share a PHD domain that is not a PHD domain, evolved to bind an MBD domain that is not an MBD domain!

febs.onlinelibrary.wiley.com/doi/10.1111/...

FEBS Press

A plant homeodomain (PHD) at the C terminus of additional sex combs-like (ASXL) proteins is recurrently truncated in disease. In the current study, the ASXL PHD was shown not to bind histone modifica...

febs.onlinelibrary.wiley.com

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Ryo Yokoyama @yokoyama-ryo.bsky.social · Aug 25

Mechanism of cyanobacterial ferredoxin‐dependent flavin thioredoxin reductase reveals thiolate‐FAD charge transfer and catalytic asymmetry in a homodimer febs.onlinelibrary.wiley.com/doi/10.1111/... @febsj.bsky.social

FEBS Press

Ferredoxin-dependent flavin thioredoxin reductases (FFTRs) regenerate reduced thioredoxin, sustaining dithiol–disulfide exchange reactions that regulate protein activity in select organisms. In cyano...

febs.onlinelibrary.wiley.com

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Reposted by The FEBS Journal

Elodie Lafont @elodie-lafont.bsky.social · 18d

Out in @febsj.bsky.social, comment written with @tonyavril.bsky.social from @csignaling.bsky.social.
https://doi:10.1111/febs.70259
The SARS-CoV-2 spike protein interacts with HAX1 to modulate cellular stress responses through activation of the UPR

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The FEBS Journal @febsj.bsky.social · Jul 29

🩸 Register today for the FEBS Workshop on Aging in Hematopoiesis that will take place in ☀️ Crete on October 20-24, 2025!

🩸 An outstanding scientific program in a beautiful location! More info: buff.ly/bSHhzR3

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The FEBS Journal @febsj.bsky.social · Jul 24

⏱️ ONE WEEK LEFT!
Travel Grants available for the FEBS Workshop on Aging in Hematopoiesis that will take place in Crete on October 20-24, 2025!
Phenomenal speakers, beautiful location & lots of opportunities to network!

⏱️ Deadline for applications: July 31. To apply ▶️: buff.ly/C1Ar5Sx

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Reposted by The FEBS Journal

Marcin J. Suskiewicz @msuskiewicz.bsky.social · Jun 5

Very happy that our SIAH1 article - published online in February - was now chosen for the cover of the new issue of the @febsj.bsky.social . Thank you @spartelab.bsky.social for the wonderful collaboration and the lovely cellular images. febs.onlinelibrary.wiley.com/toc/17424658...

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The FEBS Journal @febsj.bsky.social · May 9

🍬 Looking for #WeekendReads?
Our latest issue is ready!

🍬 #CancerMetabolism takes centre-stage in our Reviews section
🕸️ A new Viewpoint discusses #ECM preparations' effects on the environment
📰 Rich crop of #MolecularLifeSicences research articles

🍬 buff.ly/wRbis26

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Reposted by The FEBS Journal

Jose P. López-Atalaya @jplopez-atalaya.bsky.social · Apr 30

New review out with Aysha in @febsj.bsky.social. We discuss how dysregulated type-I interferon signalling affects brain function, with a focus on the IFN-responsive state of microglia. Experimental work coming soon, stay tuned! febs.onlinelibrary.wiley.com/doi/10.1111/...

FEBS Press

Recent insights reveal that type I interferon (IFN-I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN-I activity is increasingly linked to neurologica...

febs.onlinelibrary.wiley.com

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Reposted by The FEBS Journal

Review Commons @reviewcommons.org · Apr 30

Now published @febsj.bsky.social @febspress.bsky.social

--> doi.org/10.1111/febs...

FEBS Press

Metastatic progression is characterised by extensive remodelling of the extracellular matrix, primarily mediated by secreted proteases, including ADAMTS family members. Rainero and colleagues found t...

doi.org

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The FEBS Journal @febsj.bsky.social · Apr 28

🧬 @febspress.bsky.social is hiring!

Join The FEBS Journal as a full-time Editor 📚

🌍 Fully remote, UK-based, permanent role
📅 Deadline: 31 May 2025
📩 Send your CV, cover letter, and a 200-word research highlight to: [email protected]

Learn more ➡️ febs.org/news/jobs-po...

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Reposted by The FEBS Journal

Cristina Muñoz Pinedo @crismunozp.bsky.social · Apr 24

A reviewer asked: but why is IRE1 activated when glucose is low?
A committee member for Mabel Cruz's PhD asked: why is the UPR activated upon glucose deprivation?
So we wrote a review about it.
Here it is!
@ericchevet.bsky.social @febsj.bsky.social
febs.onlinelibrary.wiley.com/doi/10.1111/...

FEBS Press

The unfolded protein response (UPR) is engaged by perturbations of protein folding in the endoplasmic reticulum (ER). Here, we compile evidence that the UPR is activated by physiological and patholog...

febs.onlinelibrary.wiley.com

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The FEBS Journal @febsj.bsky.social · Apr 24

🔋 Adipocytes are much more than energy storage.
@mcsinton.bsky.social & Shingo Kajimura make the case for their role as immune hubs:

🔋 buff.ly/LZpiByg
Part of our latest issue w/ #immunology focussed front half:
📗 buff.ly/6W7NkMV

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The FEBS Journal @febsj.bsky.social · Apr 23

🦠 Fix your #HumpDay blues with our latest issue:
Your journey starts with a healthy helping of #immunology reviews & takes you through the best and brightest original research in the molecular life sciences:

🦠 buff.ly/6W7NkMV

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The FEBS Journal @febsj.bsky.social · Apr 16

🌦️ April showers have come to England, but we shan't let puddles bring us down. We're cheering ourselves up with our #MostRead papers.

Join the fun here:
🌦️ buff.ly/BxPu2Uy

Reposted by The FEBS Journal

UK Cellular Microbiology @ukcellmicro.bsky.social · Apr 14

🏆 We are pleased to offer ECR prizes at the meeting:

- 2 prizes for outstanding talks, sponsored by the Company of Biologists (Disease Models & Mechanisms and Journal of Cell Science)

- 2 prizes for exceptional posters, sponsored by the FEBS Journal.

@biologists.bsky.social
@febsj.bsky.social

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The Meshwork @themeshwork.bsky.social · Apr 1

🎉 Exciting new research out of the @erainerolab.bsky.social available now in @febsj.bsky.social OPEN access!!! A great read for ECM aficionados and those interested in the role of ADAMTS5 in ovarian cancer! 👏 Congrats to the authors! 🧬🔬

Rainero lab @erainerolab.bsky.social · Apr 1

Excited to share that our latest paper is out today!!!
'The protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25' - great effort by Sherry and Rachele (1/6)
@febsj.bsky.social
@mcb-sheffield.bsky.social
febs.onlinelibrary.wiley.com/doi/full/10....

FEBS Press

Metastatic progression is characterised by extensive remodelling of the extracellular matrix, primarily mediated by secreted proteases, including ADAMTS family members. Rainero and colleagues found t....

febs.onlinelibrary.wiley.com

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