Federico Gaiti
@fgaiti.bsky.social
Cancer Researcher at Princess Margaret Cancer Centre, Assistant Professor at U of T
📖 Read here: www.sciencedirect.com/science/arti...
Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration
Glioblastoma (GBM) is an aggressive brain tumor with a highly invasive nature. Despite the clinical relevance of this behavior, the molecular underpin…
www.sciencedirect.com
May 16, 2025 at 3:47 PM
📖 Read here: www.sciencedirect.com/science/arti...
Proud to contribute to the field of #CancerNeuroscience, building on the foundational work of leaders and pioneers in the field!
May 16, 2025 at 3:47 PM
Proud to contribute to the field of #CancerNeuroscience, building on the foundational work of leaders and pioneers in the field!
🙏 Huge thanks to our incredible collaborators @uhn.ca @uhnresearch.ca @pmresearch-uhn.bsky.social , the patients & families, and our funders @CIHR @NSERC @pmresearch-uhn.bsky.social @theabta.bsky.social @oicr.on.ca @braincanada.bsky.social @src-crs.bsky.social @terryfoxresearch.bsky.social
May 16, 2025 at 3:47 PM
🙏 Huge thanks to our incredible collaborators @uhn.ca @uhnresearch.ca @pmresearch-uhn.bsky.social , the patients & families, and our funders @CIHR @NSERC @pmresearch-uhn.bsky.social @theabta.bsky.social @oicr.on.ca @braincanada.bsky.social @src-crs.bsky.social @terryfoxresearch.bsky.social
💡 What’s next? Can we target these epigenetically sustained cell states or disrupt tumor-neuron crosstalk to limit recurrence?
May 16, 2025 at 3:47 PM
💡 What’s next? Can we target these epigenetically sustained cell states or disrupt tumor-neuron crosstalk to limit recurrence?
➡️ Our findings provide insights into the neurodevelopmental hijacking that drives GBM infiltration in patients, revealing how tumor cells mimic brain development to invade.
May 16, 2025 at 3:47 PM
➡️ Our findings provide insights into the neurodevelopmental hijacking that drives GBM infiltration in patients, revealing how tumor cells mimic brain development to invade.
We found that:
🧬 Infiltrating GBM cells adopt an uncommitted oligodendrocyte progenitor-like state
⚡ They engage in synaptic signaling and neuron-tumor crosstalk
🧠 This state is epigenetically regulated and sustained by developmental transcription factors such as ZEB1, and others
🧬 Infiltrating GBM cells adopt an uncommitted oligodendrocyte progenitor-like state
⚡ They engage in synaptic signaling and neuron-tumor crosstalk
🧠 This state is epigenetically regulated and sustained by developmental transcription factors such as ZEB1, and others
May 16, 2025 at 3:47 PM
We found that:
🧬 Infiltrating GBM cells adopt an uncommitted oligodendrocyte progenitor-like state
⚡ They engage in synaptic signaling and neuron-tumor crosstalk
🧠 This state is epigenetically regulated and sustained by developmental transcription factors such as ZEB1, and others
🧬 Infiltrating GBM cells adopt an uncommitted oligodendrocyte progenitor-like state
⚡ They engage in synaptic signaling and neuron-tumor crosstalk
🧠 This state is epigenetically regulated and sustained by developmental transcription factors such as ZEB1, and others
We performed single-cell and spatial profiling of infiltrating GBM cells directly from human patients, moving beyond preclinical models to reveal how these cells behave at the invasive edge in the human brain.
May 16, 2025 at 3:47 PM
We performed single-cell and spatial profiling of infiltrating GBM cells directly from human patients, moving beyond preclinical models to reveal how these cells behave at the invasive edge in the human brain.