FinnGen
@finngen.bsky.social
300 followers
140 following
47 posts
A forerunner in the global landscape of genomics research projects. The study has collected and analysed genome and health data from >500,000 Finnish biobank donors to understand the genetic basis of diseases.
www.finngen.fi
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FinnGen
@finngen.bsky.social
· Aug 18
<em>Acta Obstetricia et Gynecologica Scandinavica</em> | NFOG Women's Health Journal | Wiley Online Library
FinnGen data of 213 942 women was utilized in order to investigate the risk of cardiovascular disease in women with and without hypertensive disorders of pregnancy and with diverse genetic risks for ...
doi.org
FinnGen
@finngen.bsky.social
· Aug 18
Genome-wide association study of pulpal and apical diseases - Nature Communications
Here the authors aim to further increase our understanding of host genetic variants predisposition to endodontic infections and perform a GWAS on FinnGen participants with diagnosis codes of pulpal an...
doi.org
FinnGen
@finngen.bsky.social
· Aug 18
Genetic Loci Associated With Periodontitis: The FinnGen Study Based on National Health Registers
Aim
To perform a genome-wide association study (GWAS) for periodontitis in the FinnGen cohort, as genetic factors contribute to periodontitis.
Materials and Methods
We included nearly 250,000 Finn.....
doi.org
FinnGen
@finngen.bsky.social
· Aug 18
Recessive FANCM cancer syndrome with high cancer risks, chemotherapy toxicity, chromosome fragility, and gonadal failure
Heterozygous FANCM variants have been associated with breast cancer. Only a few studies have examined other cancer types. Biallelic truncating variant…
www.sciencedirect.com
FinnGen
@finngen.bsky.social
· Aug 18
Loss of CFHR5 function reduces the risk for age-related macular degeneration - Nature Communications
This study in the Finnish population reveals genetic reduction of the complement factor CFHR5 as enhancing retinal health and reducing the risk for age-related macular degeneration (AMD), suggesting n...
doi.org
FinnGen
@finngen.bsky.social
· Aug 6
Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty - Nature Aging
To better understand the etiology of frailty, the authors perform a large genetic study. They identified 45 additional variants and implicated MET, CHST9, ILRUN, APOE, CGREF1 and PPP6C as potential ca...
www.nature.com
FinnGen
@finngen.bsky.social
· Aug 6
Genes reveal why some older people suffer from frailty
A new study has identified genetic variants linked to brain function, immune defence and metabolism that contribute to the development of frailty in older people. The study, published in Nature Aging ...
news.ki.se
FinnGen
@finngen.bsky.social
· Jul 4
Polygenic scores for obstructive sleep apnoea reveal pathways contributing to cardiovascular disease
Obstructive sleep apnoea (OSA) is a common chronic condition, with obesity its strongest risk factor. Polygenic scores (PGSs) summarise the genetic li…
www.sciencedirect.com
FinnGen
@finngen.bsky.social
· Jul 4
Incorporating genetic data improves target trial emulations and informs the use of polygenic scores in randomized controlled trial design - Nature Genetics
This study integrates polygenic risk scores with four emulated clinical trials using FinnGen data and shows the feasibility of this approach while highlighting potential pitfalls.
www.nature.com
FinnGen
@finngen.bsky.social
· Jul 4
Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression - Molecular Psychiatry
Molecular Psychiatry - Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression
www.nature.com
FinnGen
@finngen.bsky.social
· Jun 11
Twin Study Provides Heritability Estimates for 2321 Plasma Proteins and Assesses Missing SNP Heritability
Assessing how much variability in blood plasma proteins is due to genetic or environmental factors is essential for advancing personalized medicine. While large-scale studies have established SNP-base...
pubs.acs.org
FinnGen
@finngen.bsky.social
· Jun 11
Genome-wide association study of long COVID - Nature Genetics
A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.
www.nature.com
FinnGen
@finngen.bsky.social
· Jun 11
Cross‐sectional study of plasma phosphorylated tau 217 in persons without dementia
INTRODUCTION Little is known about plasma phosphorylated tau 217 (p-tau217) in individuals without a clinical diagnosis of Alzheimer's disease (AD). We studied associations of plasma p-tau217 with a...
alz-journals.onlinelibrary.wiley.com
FinnGen
@finngen.bsky.social
· Jun 11
Chromatin state origins of uterine leiomyoma - Nature Communications
The chromatin state origins of uterine leiomyoma (UL) remain to be explored. Here, the authors integrate data from genome-wide association studies and deep regulatory genomics data from myometrium and...
www.nature.com
FinnGen
@finngen.bsky.social
· Jun 11
Rare genetic variation in PTPRB is associated with central serous chorioretinopathy, varicose veins and glaucoma - Nature Communications
Central serous chorioretinopathy is an eye disease whose etiology is not well known. Here, the authors performed genetic association studies and identified vascular endothelial protein tyrosine phosph...
www.nature.com