FOR5596 - SAM-dependent enzyme chemistry
@for5596.bsky.social
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"Unfolding the potential of SAM-dependent enzyme chemistry" Research group funded by the DFG https://for5596.uni-freiburg.de/
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for5596.bsky.social
We are also looking forward to the presentations by Dr. Anna Vagstad and our group member, Tenure-Track Professor Dr. Lena Barra @barra-lab.bsky.social, at the Young Researchers Session in Irsee.
for5596.bsky.social
We are organizing a session on SAM-dependent enzymes at the 38th Irsee Natural Product Symposium, February 25-27, 2026. We are pleased to welcome the following speakers:
Prof. Andrea Rentmeister, Prof. Jörg Pietruszka, and Prof. Andreas Kirschning.

Please spread the news and join us in Irsee!
for5596.bsky.social
Greetings to all the doctoral researchers of the FOR5596 research unit who spent the last week at a summer school in Berlin!
for5596.bsky.social
Congratulations to FOR5596 member Andrea @rentmeisterlab.bsky.social for receiving the Wittig-Grignard Award!! 🎉
rentmeisterlab.bsky.social
It was an honour to give a talk today in the historic lecture hall of Université Paris Cité, Faculté de Pharmacie after receiving the Wittig-Grignard Award yesterday. Thank you very much Bruno Sargueil and Mélanie Ethève-Quelquejeu for the invitation 🤩
Reposted by FOR5596 - SAM-dependent enzyme chemistry
rentmeisterlab.bsky.social
Ever wondered why prenylation and methylation use different cofactor scaffolds? We now show that the SAM scaffold enables both: Chimeric cofactors enable methyltransferase-catalyzed prenylation: Chem www.cell.com/chem/fulltex... Kudos to @nicocorn.bsky.social & Arne Hoffmann and all authors 👌👏🤩
Chimeric cofactors enable methyltransferase-catalyzed prenylation
In nature, many methyltransferases (C1) use S-adenosyl-l-methionine (AdoMet or SAM) as a cofactor for methyl transfer, whereas prenyltransferases (C5) use dimethylallyl diphosphate (DMAPP). We enginee...
www.cell.com
for5596.bsky.social
New FOR5596 paper from the Müller, Garcia Borràs and Andexer groups!
Reposted by FOR5596 - SAM-dependent enzyme chemistry
for5596.bsky.social
FOR 5596 is now on BlueSky! Follow us to stay informed about our collaborative project "Unfolding the potential of SAM-dependent enzyme chemistry".
logo of research group FOR 5596 on SAM-dependent enzyme chemistry showing the chemical structure of S-adenosylmethionine