F. Perry Wilson, MD
@fperrywilson.bsky.social
Director, Clinical and Translational Research Accelerator @Yale. Columnist @medscape.
How Medicine Works and When It Doesn't in bookstores now!
How Medicine Works and When It Doesn't in bookstores now!
I’ve called GLP-1 agents like Ozempic and Mounjaro "miracle drugs." But a new study forces me to re-evaluate that moniker.
The miracle has a problem: It ends when the prescription runs out.
Let's look at the data on the "Rebound Effect." 🧵
The miracle has a problem: It ends when the prescription runs out.
Let's look at the data on the "Rebound Effect." 🧵
November 24, 2025 at 11:27 PM
I’ve called GLP-1 agents like Ozempic and Mounjaro "miracle drugs." But a new study forces me to re-evaluate that moniker.
The miracle has a problem: It ends when the prescription runs out.
Let's look at the data on the "Rebound Effect." 🧵
The miracle has a problem: It ends when the prescription runs out.
Let's look at the data on the "Rebound Effect." 🧵
A new randomized trial in American Journal of Psychiatry just dropped, and the headline result is…unexpected: smoking marijuana REDUCED alcohol consumption. Yes, reduced. And before you say “that makes no sense", let’s unpack it. (🧵)
November 19, 2025 at 4:24 PM
A new randomized trial in American Journal of Psychiatry just dropped, and the headline result is…unexpected: smoking marijuana REDUCED alcohol consumption. Yes, reduced. And before you say “that makes no sense", let’s unpack it. (🧵)
Young people today have more friends than any generation before them. They also report the highest levels of loneliness.
How is that possible? Turns out the answer is fascinating and maybe a little depressing. 🧵
How is that possible? Turns out the answer is fascinating and maybe a little depressing. 🧵
November 12, 2025 at 7:53 PM
Young people today have more friends than any generation before them. They also report the highest levels of loneliness.
How is that possible? Turns out the answer is fascinating and maybe a little depressing. 🧵
How is that possible? Turns out the answer is fascinating and maybe a little depressing. 🧵
The use of doxycycline in childhood may protect against the future development of schizophrenia.
Wait... what?
This is one of those studies that makes you say "that can't be right." But maybe it is?
Let me walk you through this weird one.
Wait... what?
This is one of those studies that makes you say "that can't be right." But maybe it is?
Let me walk you through this weird one.
November 6, 2025 at 6:41 PM
The use of doxycycline in childhood may protect against the future development of schizophrenia.
Wait... what?
This is one of those studies that makes you say "that can't be right." But maybe it is?
Let me walk you through this weird one.
Wait... what?
This is one of those studies that makes you say "that can't be right." But maybe it is?
Let me walk you through this weird one.
What killed Napoleon's army in 1812? For 200+ years, history books have pointed to epidemic typhus. Turns out, they may have been completely wrong. A new study just rewrote one of military history's greatest mysteries. 🧵
October 29, 2025 at 9:07 PM
What killed Napoleon's army in 1812? For 200+ years, history books have pointed to epidemic typhus. Turns out, they may have been completely wrong. A new study just rewrote one of military history's greatest mysteries. 🧵
What killed Napoleon's army in 1812? For 200+ years, history books have pointed to epidemic typhus. Turns out, they may have been completely wrong. A new study just rewrote one of military history's greatest mysteries. 🧵
October 29, 2025 at 9:05 PM
What killed Napoleon's army in 1812? For 200+ years, history books have pointed to epidemic typhus. Turns out, they may have been completely wrong. A new study just rewrote one of military history's greatest mysteries. 🧵
A new Nature study found that people with cancer who received an mRNA COVID vaccine while on immunotherapy lived nearly twice as long. Median survival jumped from 20.6 to 37.3 months.
That’s not a typo. Let’s talk about how, and why, that might be. 🧵
That’s not a typo. Let’s talk about how, and why, that might be. 🧵
October 22, 2025 at 3:26 PM
A new Nature study found that people with cancer who received an mRNA COVID vaccine while on immunotherapy lived nearly twice as long. Median survival jumped from 20.6 to 37.3 months.
That’s not a typo. Let’s talk about how, and why, that might be. 🧵
That’s not a typo. Let’s talk about how, and why, that might be. 🧵
There's a problem with BMI, and I can illustrate it like this: Seth Rogen (comedic legend, dad bod) has about the same BMI as Jalen Hurts (elite NFL QB, built like a tank). Both would be classified as "overweight" or nearly "obese." Clearly, something is wrong here. (🧵)
October 15, 2025 at 2:48 PM
There's a problem with BMI, and I can illustrate it like this: Seth Rogen (comedic legend, dad bod) has about the same BMI as Jalen Hurts (elite NFL QB, built like a tank). Both would be classified as "overweight" or nearly "obese." Clearly, something is wrong here. (🧵)
I woke up in Las Vegas last week with some mysterious symptoms: pounding headache, nausea, feeling like I hadn't slept at all. Who knows what could cause such a thing? As I searched for coffee, I saw a sign promising salvation: IV fluids. On demand. For $248. 🧵
October 6, 2025 at 11:21 PM
I woke up in Las Vegas last week with some mysterious symptoms: pounding headache, nausea, feeling like I hadn't slept at all. Who knows what could cause such a thing? As I searched for coffee, I saw a sign promising salvation: IV fluids. On demand. For $248. 🧵
🧵 New headlines say rising cancer rates in young people might be... fake? Before you panic (or un-panic), let's talk about why this is both more complicated AND more interesting than it sounds. Spoiler: I'm still getting my colonoscopy. 1/
October 1, 2025 at 10:16 PM
🧵 New headlines say rising cancer rates in young people might be... fake? Before you panic (or un-panic), let's talk about why this is both more complicated AND more interesting than it sounds. Spoiler: I'm still getting my colonoscopy. 1/
🧵 Walk into any pharmacy and you'll see supplement bottles claiming to "support heart health" or "boost immune function." These vague promises are everywhere. But here's the thing: a new study just proved these weasel words are fooling millions of Americans.
September 23, 2025 at 2:37 PM
🧵 Walk into any pharmacy and you'll see supplement bottles claiming to "support heart health" or "boost immune function." These vague promises are everywhere. But here's the thing: a new study just proved these weasel words are fooling millions of Americans.
Childhood obesity has quadrupled since the 1960s. Now over 20% of kids meet the definition (>95th percentile of BMI).
This is driving type 2 diabetes in children, and increases the risk of other diseases as adults.
We need to talk about weight-loss drugs for kids. 🧵
This is driving type 2 diabetes in children, and increases the risk of other diseases as adults.
We need to talk about weight-loss drugs for kids. 🧵
September 16, 2025 at 5:36 PM
Childhood obesity has quadrupled since the 1960s. Now over 20% of kids meet the definition (>95th percentile of BMI).
This is driving type 2 diabetes in children, and increases the risk of other diseases as adults.
We need to talk about weight-loss drugs for kids. 🧵
This is driving type 2 diabetes in children, and increases the risk of other diseases as adults.
We need to talk about weight-loss drugs for kids. 🧵
Really excited to be speaking at @Medium Day this Friday.
I'll be talking about how to write about medicine while maintaining both skepticism and joy. Tons of amazing talks / discussions.
You can sign up for free here: www.mediumday.com
I'll be talking about how to write about medicine while maintaining both skepticism and joy. Tons of amazing talks / discussions.
You can sign up for free here: www.mediumday.com
September 16, 2025 at 1:47 PM
Really excited to be speaking at @Medium Day this Friday.
I'll be talking about how to write about medicine while maintaining both skepticism and joy. Tons of amazing talks / discussions.
You can sign up for free here: www.mediumday.com
I'll be talking about how to write about medicine while maintaining both skepticism and joy. Tons of amazing talks / discussions.
You can sign up for free here: www.mediumday.com
We've all had this conversation before:
"Dude, we both agree this is red... but how do I know what I see as red is what you see as red? Maybe you see red as I see blue."
Mind blown lol.
But we finally have some research that sheds light (and color) on the issue. (Thread)
"Dude, we both agree this is red... but how do I know what I see as red is what you see as red? Maybe you see red as I see blue."
Mind blown lol.
But we finally have some research that sheds light (and color) on the issue. (Thread)
September 9, 2025 at 6:53 PM
We've all had this conversation before:
"Dude, we both agree this is red... but how do I know what I see as red is what you see as red? Maybe you see red as I see blue."
Mind blown lol.
But we finally have some research that sheds light (and color) on the issue. (Thread)
"Dude, we both agree this is red... but how do I know what I see as red is what you see as red? Maybe you see red as I see blue."
Mind blown lol.
But we finally have some research that sheds light (and color) on the issue. (Thread)
Ok, this study has some pretty predictable conclusions. But I have some serious questions. (Thread):
September 3, 2025 at 8:57 PM
Ok, this study has some pretty predictable conclusions. But I have some serious questions. (Thread):
Marijuana ain't what it used to be. Not by a long shot. In 1995, weed had about 4% THC. Today? We're pushing 20%.And that's just from breeding. We can extract THC to 70, 80, even 95% purity.
Should we be worried? 🧵
Should we be worried? 🧵
August 26, 2025 at 10:19 PM
Marijuana ain't what it used to be. Not by a long shot. In 1995, weed had about 4% THC. Today? We're pushing 20%.And that's just from breeding. We can extract THC to 70, 80, even 95% purity.
Should we be worried? 🧵
Should we be worried? 🧵
63% of physicians are burnt out, the highest rate of any US profession.
When docs burn out, patients suffer: more medical errors, more malpractice suits, even increased racial biases.
A new Mayo Clinic study says smartwatches might cut burnout in half. Really? 🧵
When docs burn out, patients suffer: more medical errors, more malpractice suits, even increased racial biases.
A new Mayo Clinic study says smartwatches might cut burnout in half. Really? 🧵
August 19, 2025 at 11:32 PM
63% of physicians are burnt out, the highest rate of any US profession.
When docs burn out, patients suffer: more medical errors, more malpractice suits, even increased racial biases.
A new Mayo Clinic study says smartwatches might cut burnout in half. Really? 🧵
When docs burn out, patients suffer: more medical errors, more malpractice suits, even increased racial biases.
A new Mayo Clinic study says smartwatches might cut burnout in half. Really? 🧵
About a year ago, I joked with a friend about Ozempic's miracle benefits. Weight loss! Better hearts! Less drinking!
"What about side effects?" he asked.
"Maybe after 10 years your eyes fall out," I joked.
Well, about that... 🧵
"What about side effects?" he asked.
"Maybe after 10 years your eyes fall out," I joked.
Well, about that... 🧵
August 17, 2025 at 4:27 PM
About a year ago, I joked with a friend about Ozempic's miracle benefits. Weight loss! Better hearts! Less drinking!
"What about side effects?" he asked.
"Maybe after 10 years your eyes fall out," I joked.
Well, about that... 🧵
"What about side effects?" he asked.
"Maybe after 10 years your eyes fall out," I joked.
Well, about that... 🧵
Check out the incidence of colorectal cancers among 45-49 year old's over time.
Scary, right?
This week, I wrote about a trio of papers in @jamacurrent trying to explain this phenomonon.
Full details @medscape here: www.medscape.com/viewarticle/...
Scary, right?
This week, I wrote about a trio of papers in @jamacurrent trying to explain this phenomonon.
Full details @medscape here: www.medscape.com/viewarticle/...
August 6, 2025 at 12:20 AM
Check out the incidence of colorectal cancers among 45-49 year old's over time.
Scary, right?
This week, I wrote about a trio of papers in @jamacurrent trying to explain this phenomonon.
Full details @medscape here: www.medscape.com/viewarticle/...
Scary, right?
This week, I wrote about a trio of papers in @jamacurrent trying to explain this phenomonon.
Full details @medscape here: www.medscape.com/viewarticle/...
Thanks to a clever use of mass spectroscopy, scientists seem to have uncovered the actual "scent of a woman" - a cocktail of compounds, released during ovulation, that actually changes men's behavior. Brief thread:
July 29, 2025 at 7:55 PM
Thanks to a clever use of mass spectroscopy, scientists seem to have uncovered the actual "scent of a woman" - a cocktail of compounds, released during ovulation, that actually changes men's behavior. Brief thread:
The COVID pandemic AGED your brain by 5.5 months, on average, according to a new study. That... sounds bad. But what does "brain age" mean? And what does a brain that is aging more rapidly mean to you?
Using what's left of my brain to break down this new study.
(1/N)
Using what's left of my brain to break down this new study.
(1/N)
July 22, 2025 at 4:55 PM
The COVID pandemic AGED your brain by 5.5 months, on average, according to a new study. That... sounds bad. But what does "brain age" mean? And what does a brain that is aging more rapidly mean to you?
Using what's left of my brain to break down this new study.
(1/N)
Using what's left of my brain to break down this new study.
(1/N)
Cannabis Hyperemesis Syndrome (CHS) is rising. Wait, not rising. Skyrocketing. At least in adolescents. So... is it real?
Brief thread discussing this new study. 🧵
Brief thread discussing this new study. 🧵
July 14, 2025 at 11:58 PM
Cannabis Hyperemesis Syndrome (CHS) is rising. Wait, not rising. Skyrocketing. At least in adolescents. So... is it real?
Brief thread discussing this new study. 🧵
Brief thread discussing this new study. 🧵
Does the dinner plate affect the dream state? Does a midnight stack make your dreams more wack?
This week - some evidence for the old idea that certain foods predispose to nightmares. Here's what you need to know:
🧵
This week - some evidence for the old idea that certain foods predispose to nightmares. Here's what you need to know:
🧵
July 1, 2025 at 3:47 PM
Does the dinner plate affect the dream state? Does a midnight stack make your dreams more wack?
This week - some evidence for the old idea that certain foods predispose to nightmares. Here's what you need to know:
🧵
This week - some evidence for the old idea that certain foods predispose to nightmares. Here's what you need to know:
🧵
To a Gen X'er like me, this is an A-ha moment.
But to the rest of the world, "Aha moments are sudden flashes of insight; instances of "Eureka" where, abruptly, the solution to a problem presents itself. A new study suggests we can actually game the system... here's how:
🧵
But to the rest of the world, "Aha moments are sudden flashes of insight; instances of "Eureka" where, abruptly, the solution to a problem presents itself. A new study suggests we can actually game the system... here's how:
🧵
June 26, 2025 at 7:35 PM
To a Gen X'er like me, this is an A-ha moment.
But to the rest of the world, "Aha moments are sudden flashes of insight; instances of "Eureka" where, abruptly, the solution to a problem presents itself. A new study suggests we can actually game the system... here's how:
🧵
But to the rest of the world, "Aha moments are sudden flashes of insight; instances of "Eureka" where, abruptly, the solution to a problem presents itself. A new study suggests we can actually game the system... here's how:
🧵
Another psilocybin study out this week, and I have to admit I find this stuff completely fascinating. A single dose of an agent with potentially YEARS-long improvement in depression? (Brief thread):
June 17, 2025 at 12:52 PM
Another psilocybin study out this week, and I have to admit I find this stuff completely fascinating. A single dose of an agent with potentially YEARS-long improvement in depression? (Brief thread):