Frederik Post
@freddyomics.bsky.social
38 followers 50 following 1 posts
Deep Visual Proteomics in the Mann Lab, Copenhagen
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freddyomics.bsky.social
My first PhD paper on the spatial characterization of colon organoids is finally out!
Thanks to @hausmannannika.bsky.social for spearheading this collaboration with me. Read more about the study in the post by @mannlab.bsky.social.
mannlab.bsky.social
Out in @cp-cellsystems.bsky.social‬: Deep Visual Proteomics shows xenotransplantation drives colon #organoids toward in-vivo-like proteomes supporting their use in regenerative medicine; culture tweaks can mimic this shift. With @kimbakjensen.bsky.social. Lead author Frederik Post explains below:
Reposted by Frederik Post
hausmannannika.bsky.social
Very happy to share that part of my postdoc work @ucph.bsky.social @kimbakjensen.bsky.social lab is out now in @cp-cellsystems.bsky.social!

In close collaboration with @freddyomics.bsky.social @mannlab.bsky.social we show that orthotopically transplanted organoids recapitulate in vivo phenotypes 👇🏼
Reposted by Frederik Post
mannlab.bsky.social
Our paper is out in Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution.
Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time.
www.nature.com/articles/s41...
Deep Visual Proteomics maps proteotoxicity in a genetic liver disease - Nature
High-resolution spatial proteomics were used to map molecular events during hepatocyte stress in pseudotime across all fibrosis stages, recapitulating known disease progression markers and revealing e...
www.nature.com
Reposted by Frederik Post