Frederick
@frederickreinhart.bsky.social
PhD @ Kline Lab 🇸🇬. Bacteria, cell biology, and anything in between 🧬🧫
Reposted by Frederick
There's more! @frederickreinhart.bsky.social now shows Fsr quorum sensing turns on during intracellular replication, driving GelE-dependent host cell lysis/egress, a model for how intracellular “factories” become new extracellular inocula, primed for reinfection. 5/n www.biorxiv.org/content/10.6...
Gelatinase regulates the egress of intracellular replicating populations during Enterococcus faecalis infection
Enterococcus faecalis is a common opportunistic pathogen, frequently isolated from chronic wounds, yet the mechanisms underlying its virulence and persistence in this niche remain incompletely underst...
www.biorxiv.org
December 18, 2025 at 9:19 AM
There's more! @frederickreinhart.bsky.social now shows Fsr quorum sensing turns on during intracellular replication, driving GelE-dependent host cell lysis/egress, a model for how intracellular “factories” become new extracellular inocula, primed for reinfection. 5/n www.biorxiv.org/content/10.6...
Reposted by Frederick
🧵Enterococcus faecalis is not just an extracellular organism. 🧵 A growing body of work shows it can survive + REPLICATE inside host cells, and that intracellular life may seed persistence, dissemination, and reinfection. 1/n #MMBR @asm.org journals.asm.org/doi/10.1128/...
Enterococcus faecalis: an overlooked cell invader | Microbiology and Molecular Biology Reviews
SUMMARYEnterococcus faecalis and Enterococcus faecium are human pathobionts that exhibit a dual lifestyle as commensal and pathogenic bacteria. The pathogenic lifestyle is associated with specific conditions involving host susceptibility and intestinal ...
journals.asm.org
December 18, 2025 at 9:19 AM
🧵Enterococcus faecalis is not just an extracellular organism. 🧵 A growing body of work shows it can survive + REPLICATE inside host cells, and that intracellular life may seed persistence, dissemination, and reinfection. 1/n #MMBR @asm.org journals.asm.org/doi/10.1128/...
Reposted by Frederick
Excited to share our first look at Enterococcus faecium infection biology: diabetic wounds are complex, and E. faecium persists despite early immune responses. In diabetic mice, it shows impaired clearance + sustained neutrophil recruitment, worsening healing.
Enterococcus faecium colonization and persistence in a model of diabetic wound infection https://www.biorxiv.org/content/10.1101/2025.11.20.689639v1
November 24, 2025 at 12:37 PM
Excited to share our first look at Enterococcus faecium infection biology: diabetic wounds are complex, and E. faecium persists despite early immune responses. In diabetic mice, it shows impaired clearance + sustained neutrophil recruitment, worsening healing.