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Reposted by Frederic Schaper

Michael Fox @foxmdphd.bsky.social · 13d

Honored to moderate a panel on noninvasive mapping of human brain circuits at MGB Neuroscience Day.
Great insights from @anastasiayendiki.bsky.social
@mghmartinos.bsky.social, @fredschaper.bsky.social
@braincircuits.bsky.social, Alex Golby and Pravan Nanda @mgbneurosurgres.bsky.social.

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Reposted by Frederic Schaper

Michael Fox @foxmdphd.bsky.social · Jul 21

Honored to highlight our work @braincircuits.bsky.social @massgenbrigham.bsky.social Neuro Research Day. Thank you @shansiddiqi.bsky.social @fredschaper.bsky.social Sheena Baratano and Sam Snider for sharing your experience.

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Reposted by Frederic Schaper

Andreas Horn @andreashorn.org · Jun 24

Massive, Herculanean work by @laurenahart.bsky.social and Garance Meyer to compile and integrate findings from DBS for epilepsy (20 targets!) including meta-analytical evidence for optimal stimulation sites for the two main targets (ANT & CM). Preprint out now 👇👇

Lauren Hart @laurenahart.bsky.social · Jun 24

🧠 ⚡️ Preprint alert ⚡️ 🧠

I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.

Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...

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Reposted by Frederic Schaper

Lauren Hart @laurenahart.bsky.social · Jun 24

🧠 ⚡️ Preprint alert ⚡️ 🧠

I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.

Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...

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Reposted by Frederic Schaper

Andreas Horn @andreashorn.org · Apr 16

Very hard to say goodbye to these fantastic people.
I will miss you guys! @braincircuits.bsky.social!

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Reposted by Frederic Schaper

Bahne Bahners @bahnebahners.bsky.social · Apr 9

🚨 🥁 Preprint alert:
The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band
->> www.researchgate.net/publication/... <<--

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Reposted by Frederic Schaper

Isaiah Kletenik @isaiahneuro.bsky.social · Apr 7

How does early life adversity impact white matter brain connections and subsequent cognitive abilities?

Adversity was associated with lower white matter integrity and later difficulty with arithmetic & receptive language yet interpersonal resilience was protective.

www.pnas.org/doi/epub/10....

www.pnas.org

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Reposted by Frederic Schaper

Isaiah Kletenik @isaiahneuro.bsky.social · Mar 30

Was fun to do a podcast about our recent paper on creativity and brain disease with Dr Norman Swan @abcnewsbot.bsky.social @braincircuits.bsky.social @foxmdphd.bsky.social @harvardmed.bsky.social www.abc.net.au/listen/progr...

What brain damage tells us about creativity - ABC listen

Scientists have long been aware of a paradox of neurodegenerative disease – that as the brain deteriorates, in some patients creativity flourishes. Researchers have used imaging techniques to map cre...

www.abc.net.au

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Frederic Schaper @fredschaper.bsky.social · Mar 27

Thanks so much Barbara! Looking forward to your arrival here :)

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Frederic Schaper @fredschaper.bsky.social · Mar 25

Hi thanks for your suggestion! Great point. Doing the analysis on one hemisphere did not change results and I agree it’s important to look into laterality when doing a lesion or coordinate analysis! ☺️

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Frederic Schaper @fredschaper.bsky.social · Mar 25

Thank you so much!

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Reposted by Frederic Schaper

Anne Lipton, MD, PhD @annelipton.bsky.social · Mar 25

Epic thread!🧵 #Neurology #NeuroSky #Epilepsy #Neuroscience

Frederic Schaper @fredschaper.bsky.social · Mar 24

Is generalized epilepsy a seizure of the whole brain or a specific brain network?

In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.

Paper: nature.com/articles/s41...

A 🧵 below:

A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications

Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...

nature.com

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Frederic Schaper @fredschaper.bsky.social · Mar 25

Thanks!

Reposted by Frederic Schaper

Laveena Singla @lsingla.bsky.social · Mar 25

An amazing read and what a concise thread !!

Frederic Schaper @fredschaper.bsky.social · Mar 24

Is generalized epilepsy a seizure of the whole brain or a specific brain network?

In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.

Paper: nature.com/articles/s41...

A 🧵 below:

A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications

Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...

nature.com

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Frederic Schaper @fredschaper.bsky.social · Mar 25

Thank you!!

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Reposted by Frederic Schaper

Jim Thompson @jimthommo.bsky.social · Mar 25

This is amazing work!

Frederic Schaper @fredschaper.bsky.social · Mar 24

Is generalized epilepsy a seizure of the whole brain or a specific brain network?

In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.

Paper: nature.com/articles/s41...

A 🧵 below:

A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications

Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...

nature.com

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Reposted by Frederic Schaper

Michael Fox @foxmdphd.bsky.social · Mar 25

Lesions causing epilepsy map to a brain circuit, but what about generalized epilepsy? Great new paper (and thread) by @fredschaper.bsky.social identifies this circuit with implications for #DBS. @braincircuits.bsky.social

Frederic Schaper @fredschaper.bsky.social · Mar 24

Is generalized epilepsy a seizure of the whole brain or a specific brain network?

In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.

Paper: nature.com/articles/s41...

A 🧵 below:

A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications

Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...

nature.com

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Reposted by Frederic Schaper

Center for Brain Circuit Therapeutics @braincircuits.bsky.social · Mar 24

New @braincircuits.bsky.social paper out at @naturecomms.bsky.social 👇👇

Frederic Schaper @fredschaper.bsky.social · Mar 24

Is generalized epilepsy a seizure of the whole brain or a specific brain network?

In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.

Paper: nature.com/articles/s41...

A 🧵 below:

A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications

Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...

nature.com

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Reposted by Frederic Schaper

Andreas Horn @andreashorn.org · Mar 24

Fantastic new work by @fredschaper.bsky.social on mapping epilepsy onto brain networks! Congratulations Fred & team!

Frederic Schaper @fredschaper.bsky.social · Mar 24

Is generalized epilepsy a seizure of the whole brain or a specific brain network?

In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.

Paper: nature.com/articles/s41...

A 🧵 below:

A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications

Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...

nature.com

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Frederic Schaper @fredschaper.bsky.social · Mar 24

Thanks so much Andy! ☺️

Frederic Schaper @fredschaper.bsky.social · Mar 24

a cartoon that says that 's all folks in white letters

ALT: a cartoon that says that 's all folks in white letters

media.tenor.com

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Frederic Schaper @fredschaper.bsky.social · Mar 24

Huge thank you to first author Gongjun Ji for leading this study, to @foxmdphd.bsky.social for his invaluable mentorship at @braincircuits.bsky.social, and all collaborators for their support and generous sharing of their data:

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Frederic Schaper @fredschaper.bsky.social · Mar 24

We then combined the networks of brain abnormalities in IGE with the CM DBS data and identified a convergent IGE network, which could represent a brain stimulation target to better control generalized seizures.

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Frederic Schaper @fredschaper.bsky.social · Mar 24

The thalamic peak in our IGE network even converged on the same MNI coordinate as a recently identified DBS sweet-spot for IGE, potentially suggesting an optimal DBS target based on connectivity of brain abnormalities in IGE.

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