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Reposted by Bahne Bahners

Lauren Hart @laurenahart.bsky.social · Jun 24

🧠 ⚡️ Preprint alert ⚡️ 🧠

I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.

Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...

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Reposted by Bahne Bahners

Alexander Li Cohen @drdrxanderli.bsky.social · Jun 17

Thrilled our ADHD network mapping work is now out in Annals of the Child Neurology Society, and honored to be featured on the cover!
🔗 Full article: onlinelibrary.wiley.com/doi/full/10....

@childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social

Coordinate Network Mapping of Focal Brain Volume Differences in ADHD Reveals Common Patterns That Lack Specificity: A Systematic Review

Objective Attention-deficit/hyperactivity disorder (ADHD) has been associated with decreased regional brain volume, yet no consistent localization has emerged across studies. This discrepancy has be...

onlinelibrary.wiley.com

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Reposted by Bahne Bahners

Sergiu Groppa @segroppa.bsky.social · Jun 10

Take a look at our new work, providing explanations for the mechanisms of deep brain stimulation, with insights into the modulation of motor- premotor cortex activity from mouse-based and translatable research methodologies for future therapy solutions
shorturl.at/5Atjh

Frequency- and layer-specific effects of high-frequency STN stimulation on mouse motor cortical areas in vivo

Abstract. High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective evidence-based therapy for Parkinson’s disease; howe

shorturl.at

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Reposted by Bahne Bahners

Benjamin Kay @benjaminkay.bsky.social · May 22

My med school textbook says stimulants like Ritalin treat hyperactivity by “stimulating” the brain’s attention and cognitive control systems. We studied children taking stimulants in the ABCD Study, and the largest differences were actually in arousal and reward networks! Check out our preprint!

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Reposted by Bahne Bahners

Lukas Goede @lukasgoede.bsky.social · May 22

Tremor is a common symptom across many neurological disorders.

But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?

We think: yes.

Our study is out now in @natcomms.nature.com:

🔗 www.nature.com/articles/s41...

🧵 A thread.

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Reposted by Bahne Bahners

Lukas Goede @lukasgoede.bsky.social · May 19

Big thanks to @patriciazvarova.bsky.social and @bahnebahners.bsky.social for their wonderful contributions, and to @andreashorn.org for his mentorship on this project!

Read the full study here:

onlinelibrary.wiley.com/doi/10.1002/...

Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge?

Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 P....

onlinelibrary.wiley.com

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Bahne Bahners @bahnebahners.bsky.social · Apr 9

I would like to thank the #ThiemannFoundation, who support me as well as amazing young talents like @barbarahollunder.bsky.social , @lukasgoede.bsky.social and many more.

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Bahne Bahners @bahnebahners.bsky.social · Apr 9

None the least, we would like to thank all patients that devoted their time and effort to make this study possible.
Special thanks to the best #mentor you could wish for and who led me through this project: the one and only @andreashorn.org

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Bahne Bahners @bahnebahners.bsky.social · Apr 9

I would like to thank the large set of interdisciplinary #collaborators from Berlin, Düsseldorf and Boston, who contributed their clinical, neuroscientific and technical expertise and helped gather the unique dataset over the last 15(!) years.

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Bahne Bahners @bahnebahners.bsky.social · Apr 9

Our results provide cross-modal insight into the DBS response of Parkinson’s disease, showing that effective stimulation sites are maximally engaged with a specific brain network in the #highbeta frequency band.

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Bahne Bahners @bahnebahners.bsky.social · Apr 9

We show that this network, once identified, is capable of #predicting the #DBS response across DBS centers, #surgeons, and even #MEG devices.

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Bahne Bahners @bahnebahners.bsky.social · Apr 9

We show that the identified network spatially resembles the one characterized by #fMRI and that it predominantly #communicates in the #highbeta range, which has already been identified as key for DBS response, before.

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Bahne Bahners @bahnebahners.bsky.social · Apr 9

To answer this question, we analyzed the lion’s share of the globally available #MEG-LFP data (n = 100 hemispheres) to characterize the #DBS response network in Parkinson’s Disease in both, the #spatial and #temporal domain.

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Bahne Bahners @bahnebahners.bsky.social · Apr 9

While the #DBS response network is well-defined in #Parkinson’sDisease based on #fMRI network mapping studies, a big shortcoming of fMRI is temporal resolution.
Hence, we know where the network lives, but we do not know in which #frequency band(s) it operates. doi.org/10.1002/ana....

Connectivity Predicts deep brain stimulation outcome in Parkinson disease

Objective The benefit of deep brain stimulation (DBS) for Parkinson disease (PD) may depend on connectivity between the stimulation site and other brain regions, but which regions and whether connec.....

doi.org

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Bahne Bahners @bahnebahners.bsky.social · Apr 9

🚨 🥁 Preprint alert:
The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band
->> www.researchgate.net/publication/... <<--

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Reposted by Bahne Bahners

Frederic Schaper @fredschaper.bsky.social · Mar 24

Is generalized epilepsy a seizure of the whole brain or a specific brain network?

In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.

Paper: nature.com/articles/s41...

A 🧵 below:

A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications

Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...

nature.com

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Reposted by Bahne Bahners

Jim Thompson @jimthommo.bsky.social · Mar 25

This is amazing work!

Frederic Schaper @fredschaper.bsky.social · Mar 24

Is generalized epilepsy a seizure of the whole brain or a specific brain network?

In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.

Paper: nature.com/articles/s41...

A 🧵 below:

A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications

Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...

nature.com

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Reposted by Bahne Bahners

Andreas Horn @andreashorn.org · Apr 4

Congratulations to *Dr.* @barbarahollunder.bsky.social for a summa cum laude in her PhD earned at Charité today!

Barbara is already a rock-star with multiple awards including the @dbsthinktank.bsky.social rising star award, an @ohbmofficial.bsky.social merit award and multiple German awards. …

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Prof. Vladimir Litvak @vlitvak.bsky.social · Apr 4

Well done @barbarahollunder.bsky.social and I believe the excellent mentors deserve a lot of credit as well.

Andreas Horn @andreashorn.org · Apr 4

Congratulations to *Dr.* @barbarahollunder.bsky.social for a summa cum laude in her PhD earned at Charité today!

Barbara is already a rock-star with multiple awards including the @dbsthinktank.bsky.social rising star award, an @ohbmofficial.bsky.social merit award and multiple German awards. …

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Reposted by Bahne Bahners

Colin Hoy @colinwhoy.bsky.social · Mar 1

Very helpful to see this comprehensive view of what dopamine and DBS are doing in the cortico-basal ganglia loops!

Thomas S. Binns @tsbinns.com · Feb 18

Excited to have my PhD project paper exploring the network mechanisms of neuromodulation accepted for publication!

We show how deep brain stimulation and medication exert a shared modulation of motor network synchrony in Parkinson's disease.

Schematic summary of therapeutic effects of dopamine and deep brain stimulation (DBS) across spatial, spectral, and temporal scales in Parkinson's disease.

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Reposted by Bahne Bahners

Andreas Horn @andreashorn.org · Mar 21

Interested in an update on connectomic and adaptive deep brain stimulation for obsessive compulsive disorder?

Take a look at our summary of this exciting field and how things could be brought together out now in BPS:

www.biologicalpsychiatryjournal.com/article/S000...

A brief 🧵

Deep Brain Stimulation response circuits in Obsessive Compulsive Disorder

In the field of deep brain stimulation (DBS), two major themes are currently making significant progress. First, the framework of connectomic DBS, in which circuits that are associated with improvemen...

www.biologicalpsychiatryjournal.com

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Earl K. Miller @earlkmiller.bsky.social · Mar 12

Yeah they do
Traveling Waves Integrate Spatial Information Through Time
Blog:
kempnerinstitute.harvard.edu/research/dee...
Paper:
arxiv.org/abs/2502.06034
#neuroscience

Traveling Waves Integrate Spatial Information Through Time - Kempner Institute

The act of vision is a coordinated activity involving millions of neurons in the visual cortex, which communicate over distances spanning up to centimeters on the cortical surface. How do […]

kempnerinstitute.harvard.edu

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Andreas Horn @andreashorn.org · Mar 3

Had a wonderful conversation with Jonathan Downar on @stimulatingbrains.org – Jonathan is one of the folks who may make you feel you have been wasting your time for the last years – but does so in a positive, very inspiring way. Certainly one of the key thought leaders in the neuromod space! Tune in

Stimulating Brains @stimulatingbrains.org · Mar 3

Can an entire treatment course of TMS for depression be condensed into a single day? Find out in this very inspiring conversation with Jonathan Downar here:

stimulatingbrains.org/67-jonathan-...

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Reposted by Bahne Bahners

Thomas S. Binns @tsbinns.com · Feb 18

Excited to have my PhD project paper exploring the network mechanisms of neuromodulation accepted for publication!

We show how deep brain stimulation and medication exert a shared modulation of motor network synchrony in Parkinson's disease.

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Reposted by Bahne Bahners

Andreas Horn @andreashorn.org · Feb 28

Very excited by this paper led by Savir Madan & @laurenahart.bsky.social, which introduces the first self-train dataset for learning Lead-DBS and a nice tool to self-assess how well localizations compare to expert solutions.

Aperture Neuro @apertureohbm.bsky.social · Feb 28

Madan and Hart et al. introduce Lead-Tutor, an open-access educational resource that combines an imaging dataset of anonymized DBS cases with a software tool for self-teaching: doi.org/10.52294/001...

@laurenahart.bsky.social @andreashorn.org @jordytasserie.bsky.social @ohbmofficial.bsky.social

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