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Reposted by The French Purine Club

Eric Boué-Grabot @bouegrabot.bsky.social · Jan 25

Our editorial article published today @FrontiersIn closes the ResearchTopic: Purinergic signaling function in the #CNS in health and #diseases with 22 articles thanks to my co-editors and 145 contributing authors. #P2X #Adenosine #P2Y Front.Cell.Neurosci|

doi.org/10.3389/fncel.…

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Reposted by The French Purine Club

Nature Cell Biology @natcellbio.nature.com · 4d

💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly/4gX6njF

Remote control of AMPK via extracellular adenosine controls tissue growth - Nature Cell Biology

Zhang et al. demonstrate that AMPK can be activated by signalling metabolite, adenosine, under non-stress conditions during Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.

bit.ly

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The French Purine Club @frenchpurine.bsky.social · 29d

The next European #Purine Meeting will be hosted by the French Purine Club in Bordeaux in 2026 with the important support of the EU COST Presto coordinated by Prof. Elena Adinolfi.

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The French Purine Club @frenchpurine.bsky.social · Sep 9

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The French Purine Club @frenchpurine.bsky.social · Sep 9

The French Purine Club is present at the World Congress on Purines 🇨🇳

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Reposted by The French Purine Club

thetranscendedman @atranscendedman.bsky.social · Jan 13

A study by researchers in China introduced a new purine nucleotide prodrug targeting SARS-CoV-2.

Tested on rats, the oral drug showed strong antiviral activity, safety at high doses, and lung-targeting efficacy.

pubs.acs.org/doi/10.1021/...

Discovery of a 2′-α-Fluoro-2′-β-C-(fluoromethyl) Purine Nucleotide Prodrug as a Potential Oral Anti-SARS-CoV-2 Agent

A novel 2′-α-fluoro-2′-β-C-(fluoromethyl) purine nucleoside phosphoramidate prodrug 15 has been designed and synthesized to treat SARS-CoV-2 infection. The SARS-CoV-2 central replication transcription...

pubs.acs.org

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The French Purine Club @frenchpurine.bsky.social · Jul 9

The French Purine Club is present at #Glia2025 #Marseille

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The French Purine Club @frenchpurine.bsky.social · Jul 7

A great first scientific day of the French Purine Club at ESPCI ! #FPC2025

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Reposted by The French Purine Club

Ischemia @ischemia1327.bsky.social · Jul 1

Members of INSERM UMR1327 Ischemia: Mohammed ELMALLAH, Marylou PICHONNIERE and Oumnia BENOUNA were pleased to present their work yesterday, at the Annual meeting of the @frenchpurine.bsky.social in Paris. A meeting enriched by relevant scientific discussions.

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The French Purine Club @frenchpurine.bsky.social · Jun 30

Karine Massé (Université de Bordeaux, IMN CNRS UMR5293)
"Eye and kidney embryonic development regulation: Role of alkaline phosphatase alpl"
👁️🩺 Linking ALPL to organogenesis via purinergic control.
#FPC2025 #DevelopmentalBiology

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The French Purine Club @frenchpurine.bsky.social · Jun 30

David Blum (INSERM UMR-S1172, Lille) -le vrai -.
"Adenosine A2A receptor in astrocytes triggers multicellular dysfunction in Alzheimer’s Disease"
🧠 From glial dysregulation to network-wide pathology and neuronal hyperexytability
#FPC2025 #AlzheimersResearch

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The French Purine Club @frenchpurine.bsky.social · Jun 30

Anne-Sophie Rolland (Lil'N'Cog, INSERM UMR-S1172, Lille)
"Newly diagnosed ALS patients may benefit from regular caffeine consumption" well her liming!
☕ Could coffee slow ALS progression?
#FPC2025 #Neurodegeneration #ALS #Neuroprotection

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The French Purine Club @frenchpurine.bsky.social · Jun 30

Solène Rimbert (ESPCI, CNRS UMR8249)
“The role of adenosine A2A receptor in the stabilisation and elimination of glutamatergic synapses”
#FPC2025 #A2a #development

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The French Purine Club @frenchpurine.bsky.social · Jun 30

Elena Dossi (Collège de France, INSERM U1050)
"Differential contribution of astroglial connexins to chronic seizures in mice and humans: a role for ATP?"
⚡ ATP as a hidden player in astroglial communication and epileptogenesis.
#FPC2025 #Neuroglia #Epilepsy #Astrocytes

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The French Purine Club @frenchpurine.bsky.social · Jun 30

Sara Carracedo (Université de Bordeaux)
"P2X4 receptor modifies lysosomal properties and autophagy in microglia"
P2X4 increases lysosomal size while decreasing their number
#FPC2025 #Neuroinflammation #Microglia #Lysosomes

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The French Purine Club @frenchpurine.bsky.social · Jun 30

Oumnia Benouna (Université de Tours)
"P2X4 modulates autophagy in renal tubular cells under ischemia-reperfusion"
🧪 New insights into P2X4's role in cell survival.
#FPC2025 #KidneyResearch #Autophagy #RenalCells

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The French Purine Club @frenchpurine.bsky.social · Jun 30

Thomas Grutter (Université de Strasbourg)
"New labeling method for revealing endogenous P2X7 at single-molecule level in BV2 microglia"
🔍 Cutting-edge imaging meets purinergic biology.
#FPC2025 #Neuroimaging #P2X7 #SingleMolecule

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The French Purine Club @frenchpurine.bsky.social · Jun 30

Marylou Pichonnière (UMR1327 ISCHEMIA, Tours)
"Extracellular nanovesicles as potential biomarkers of kidney-graft function recovery"
📊 EVs as a non-invasive window into renal recovery.
#FPC2025 #Transplantation #Biomarkers #P2X4 #P2X7 #KidneyTransplantation

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The French Purine Club @frenchpurine.bsky.social · Jun 30

Mohammed Elmallah (Inserm UMR1327, Tours)
"Immunomodulatory effects of breast cancer MDA-MB-231- cell-derived extracellular vesicles on monocyte-derived dendritic cells: Implication of P2X4 purinergoc receptor"
#FPC2025 #PurinergicSignaling | #BreastCancer #Immunomodulation

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The French Purine Club @frenchpurine.bsky.social · Jun 30

Valérie Vouret-Craviari (IRCAN, Nice)
"Expression of purinergic checkpoints in response to treatments in lung cancers"
💡 Toward a personalized medicine including modulators of purinergic checkpoints
#FPC2025 #CancerImmunology
#PurinergicCheckpoints

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The French Purine Club @frenchpurine.bsky.social · Jun 30

Kicking off the 3rd Annual French Purine Club Meeting in Paris,
David Blum, President of the Club, welcomes researchers to two days of cutting-edge insights on purinergic signaling in health and disease.
📍Live from ESPCI – Let the science begin!
#FPC2025

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The French Purine Club @frenchpurine.bsky.social · Jun 29

📢 Scientific Program Now Live | #FPC2025
From purinergic checkpoints in cancer to ATP signaling in neurodegeneration, the 3rd Scientific Days of the French Purine Club bring cutting-edge talks across immunology, oncology & neuroscience.
📍June 30–July 1 | ESPCI Paris

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Reposted by The French Purine Club

The French Purine Club @frenchpurine.bsky.social · Feb 12

Nous avons le plaisir de vous inviter aux 3ᵉ Journées Scientifiques du French Purine Club !
📅 30 juin à 14h au 1er juillet à 12h
📍 ESPCI, 10 rue Vauquelin, 75005 Paris
🔗 docs.google.com/forms/d/e/1F...

💡 Pensez aussi à votre cotisation annuelle
➡️ bit.ly/4hOcar6

Nous espérons vous y voir nombreux !

3e Journées Scientifiques du French Purine Club

ESPCI, 10 rue Vauquelin, 75005 Paris

docs.google.com

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The French Purine Club @frenchpurine.bsky.social · Mar 7

We stand in solidarity with the #StandUpForScience movement and with all researchers working in the United States, where academic freedom is currently being challenged.

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Reposted by The French Purine Club

Eric Boué-Grabot @bouegrabot.bsky.social · Jan 25

P2X4 contribute to ALS !or as a PDF here

link.springer.com/content/pdf/10… doi.org/10.1007/s00018…

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