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Reposted by Fritz Roth

Jeremy Berg @jeremymberg.bsky.social · 10h

Thank you, Sam. It is from the heart.

Sam Bagenstos @sbagen.bsky.social · 11h

I am really glad that @jeremymberg.bsky.social wrote this. Everybody who cares about science, and about knowledge generation and civil society generally, should read and share with their favorite administrator.

Deafening Quiet from the Scientific Establishment
open.substack.com/pub/donmoyni...

Deafening Quiet from the Scientific Establishment

Leaders are underestimating the risks of not fighting back

open.substack.com

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Reposted by Fritz Roth

The Francis Crick Institute @crick.ac.uk · 10h

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

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Reposted by Fritz Roth

Atlas of Variant Effects Alliance @varianteffect.bsky.social · 13d

📣Call for Abstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org

#FunctionalGenomics #Symposium #Australia #CallForAbstracts

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Reposted by Fritz Roth

Atlas of Variant Effects Alliance @varianteffect.bsky.social · 8d

We are #Hiring!
Communications role for our Global Alliance! 🌍🧬
Please share this post with your network, or apply if you are interested!
📍 Location: Hinxton, England
🕒 Part-time role
ℹ️ sanger.wd103.myworkdayjobs.com/en-US/Wellco...

#ScienceJobs #Communications #Genomics
#PartTimeRole #UKJobs

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Reposted by Fritz Roth

Jeremy Berg @jeremymberg.bsky.social · 13d

NSF Graduate Fellowship announcement is finally posted!

www.nsf.gov/funding/oppo...

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NSF Graduate Research Fellowship Program (GRFP)

www.nsf.gov

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Reposted by Fritz Roth

Justin Fay @justinfay.bsky.social · 15d

Very pleased to share this long term (nearly 20 years) study of yeasts isolated from vineyards and forests, now up on biorxiv:
www.biorxiv.org/content/10.1...

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Reposted by Fritz Roth

The Washington Post @washingtonpost.com · 15d

A statue of President Trump and Jeffrey Epstein holding hands has been removed from the National Mall a day after it was placed there. The statue had a permit to remain in front of the Capitol until Sunday night.

Statue of Trump and Epstein holding hands removed from National Mall

The statue, the latest installation by an anonymous group of artists critical of the president, was supposed to be on display until 8 p.m. Sunday.

www.washingtonpost.com

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Reposted by Fritz Roth

Milo B. Fasken, Ph.D. @milofasken.bsky.social · 15d

Nice!
#PolyARNA #RNA #Decay #Export #Nucleus

www.biorxiv.org/content/10.1...

Molecular basis of polyadenylated RNA fate determination in the nucleus

Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...

www.biorxiv.org

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Reposted by Fritz Roth

Elizabeth Warren @warren.senate.gov · 16d

Let's be clear: no one should be taking medical advice from the man who told Americans to inject bleach.

To moms worried about the Tylenol they took while pregnant: you deserve better than being RFK Jr's scapegoat.

And to the autism community: you are loved exactly as you are.

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Reposted by Fritz Roth

Vaughn Cooper @vscooper.micropopbio.org · 16d

🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...

Faculty Professor Associate - Full-Time | Vaughn Cooper

We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine. 1) Fundamental researc...

www.linkedin.com

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Fritz Roth @fritzroth.bsky.social · 16d

Congrats Yun will be excited to read! Did you assess performance after removing common benign variants? Perhaps the main application of variant effect predictors is classifying rare variants, but as the REVEL paper showed, common benign variants are not representative of rare benign variants.

Reposted by Fritz Roth

Dr Kathleen Millen @neurodevkathy.bsky.social · 17d

3 cheers for NIH grant staff! Regardless of everything else, they are heros!

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Reposted by Fritz Roth

Ylva Ivarsson @ivarssonlab.bsky.social · 17d

Finally out! Thrilled to share our collaboration with @kulathu.bsky.social, @orafurman.bsky.social, and N Davey. We screened auxiliary domains of USP family #deubiquitinases, revealing short linear motifs (SLiMs), contributing to specificity in complex assembly.
www.biorxiv.org/content/10.1...

Systematic Discovery of Motif-based Interactions of the Auxiliary Domains of USP Family Deubiquitinases

The ubiquitin-specific proteases (USPs) family is the largest family of human deubiquitinating enzymes (DUBs). While most USPs are agnostic to polyubiquitin linkage-type, their substrate specificity i...

www.biorxiv.org

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Reposted by Fritz Roth

Scott Delaney @scott-delaney.bsky.social · 20d

🍻🍾🎉

Side note: Gotta hand it to the student reporters at @theharvardcrimson.bsky.social. They’ve been all over this stuff for months.

Harvard Receives $46 Million in Federal Grants, Ending 4-Month Freeze | News | The Harvard Crimson

Millions of dollars in federal research grants from the National Institutes of Health have begun to flow to Harvard, the first grant money to return to the University since the Trump administration’s ...

www.thecrimson.com

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Reposted by Fritz Roth

The American Journal of Human Genetics @ajhgnews.bsky.social · 24d

📣New today!
📄Landscapes of missense variant impact for human superoxide dismutase 1
🧑‍🤝‍🧑 @axakova.bsky.social @fritzroth.bsky.social & co

Landscapes of missense variant impact for human superoxide dismutase 1

SOD1 variants cause the motor neuron disease amyotrophic lateral sclerosis. Axakova et al. functionally assay ∼86% of all possible SOD1 missense variants, producing a variant-effect map resource that ...

www.cell.com

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Reposted by Fritz Roth

Jenna Norton @jenna-m-norton.bsky.social · 25d

I am deeply saddened and angered by news that more NIH RIFs may happen next week. This is unacceptable, especially after NIH staff have worked nights & weekends to dig out from the backlog created by this admin's incompetence.

Tell your Congress people NIH needs its staff to keep delivering cures

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Fritz Roth @fritzroth.bsky.social · 26d

bsky.app/profile/jere...

Jeremy Berg @jeremymberg.bsky.social · 26d

From 2015-2024, NHLBI has averaged 9.7 4 year multi-year funded R01s. Almost all of these are non-competitive renewals.

In FY2025, NHLBI has made 3 4 multi-year funded R01s, all competitive (new or competitive renewal).

Almost all NHLBI R01s are funded annually (like other institutes and centers)

Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 26d

I'd like to see that argument made quantitatively.

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Reposted by Fritz Roth

The New York Times @nytimes.com · 26d

Democratic lawmakers in California want the state to restore funding for scientific research that has been slashed by the Trump administration, creating an ambitious plan to use tens of billions of dollars in voter-approved bonds to fill the void.

California’s $23 Billion Plan to Restore Federal Cuts to Scientific Research

Democrats are calling for the creation of a state equivalent of the National Institutes of Health, but first state lawmakers and then voters would need to approve it.

nyti.ms

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Fritz Roth @fritzroth.bsky.social · 26d

Likely scenario:
-NIH budget is flat in FY26,
-NIH continues out-year funding for ALL grants in FY26.

The extra budget freed up in FY26 by out-year funding in FY25 will come nowhere near restoring the number of new projects funded in FY26 to what it was FY25 (much less what it was in FY24).

Reposted by Fritz Roth

Jeremy Berg @jeremymberg.bsky.social · 26d

These a 4-year R01s WITH ALL FOUR YEARS FUNDED OUT OF THIS YEAR'S APPROPRIATION.

No need for non-competitive renewal awards.

Andy Vaughan @vaughandy.bsky.social · 26d

I don’t quite understand this… NHLBI has been doing 4 year R01s almost exclusively for the last at least 6-7 years, excepting only ESI / NI R01s that get 5 years. Doesn’t seem to be reflected here

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Fritz Roth @fritzroth.bsky.social · 26d

And thus each fully-funded 4-year R01 reduces what could have been four R01 research projects next year into only one. :(

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Reposted by Fritz Roth

bioRxiv Genomics @biorxiv-genomic.bsky.social · 26d

Assembly of the complete horse genome reveals variants associated with reproduction and temperamental traits https://www.biorxiv.org/content/10.1101/2025.09.10.675315v1

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Reposted by Fritz Roth

Michael Baym @baym.lol · 26d

Some good news: the NIH has now reinstated my R35 since the termination was found unconstitutional (still waiting on NSF), though the government continues to withhold the contractually obligated funds

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Fritz Roth @fritzroth.bsky.social · 27d

Thanks. Of course, even if we assumed benign intent (cough cough) and that there will be more funds available for awards next year, the amount of actual NIH-funded research on the ground next year will be reduced by the fact that fewer awards were made this year.

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Fritz Roth @fritzroth.bsky.social · 27d

Thanks @jeremymberg.bsky.social for this...your graph strongly suggests that "successfully spending the budget" is actually a thin veil of frontloaded-award smoke over a bloodbath when it comes to NIH-funded research being carried out next fiscal year.

PS I am hoping that you tell me I'm wrong!

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