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Gabriel Stine @gabrielmstine.bsky.social · 8d

Anyone know what happens with NIH deadlines during a government shut down??

Reposted by Gabriel Stine

Laureline Logiaco @laurelinelogiaco.bsky.social · 11d

Interested in doing a Ph.D. to work on building models of the brain/behavior? Consider applying to graduate schools at CU Anschutz:
1. Neuroscience www.cuanschutz.edu/graduate-pro...
2. Bioengineering engineering.ucdenver.edu/bioengineeri...

You could work with several comp neuro PIs, including me.

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Gabriel Stine @gabrielmstine.bsky.social · 21d

Congrats Thomas!

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Gabriel Stine @gabrielmstine.bsky.social · 23d

Congrats! Looking forward to reading more carefully, but it sounds like this aligns closely with how I think about things!

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Reposted by Gabriel Stine

@LaBonneLaB @labonnelab.bsky.social · Jul 26

Some journals are claiming that you need to pay big $$ for gold open access to comply with NIH's new public access policy. FYI that is total bs. You can comply by depositing the Accepted Manuscript into PubMed Central on the Date of Publication without embargo. Pass it on.

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Gabriel Stine @gabrielmstine.bsky.social · Jul 5

See you soon!

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Reposted by Gabriel Stine

Gabriel Stine @gabrielmstine.bsky.social · Jun 23

Please reach out if you want help with these probes. I benefited immensely by having early access to them, and so I feel an obligation/responsibility to help others adopt the tech. And, stay tuned for open-source hardware/software for a motorized microdrive to lower these (and other) probes!

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Reposted by Gabriel Stine

Jonathan A. Michaels @jonathanamichaels.bsky.social · Jun 23

Finally out! I've been using these probes for a few years and they have been truly transformative for us. The core experiments of my lab are based around them.

Gabriel Stine @gabrielmstine.bsky.social · Jun 23

Our paper on NHP neuropixels is finally out in Nat Neuro! These probes have already been transformative and will usher in a new era of primate neuroscience. I am extremely proud to have played a very small role in this project. I can't wait to see what our community discovers. tinyurl.com/54u3hrj8

Large-scale high-density brain-wide neural recording in nonhuman primates - Nature Neuroscience

Neuropixels 1.0 NHP is a 45-mm, high-density silicon probe capable of recording large numbers of neurons with single-neuron resolution from most areas in a macaque’s brain.

tinyurl.com

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Gabriel Stine @gabrielmstine.bsky.social · Jun 23

Please reach out if you want help with these probes. I benefited immensely by having early access to them, and so I feel an obligation/responsibility to help others adopt the tech. And, stay tuned for open-source hardware/software for a motorized microdrive to lower these (and other) probes!

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Gabriel Stine @gabrielmstine.bsky.social · Jun 23

Our paper on NHP neuropixels is finally out in Nat Neuro! These probes have already been transformative and will usher in a new era of primate neuroscience. I am extremely proud to have played a very small role in this project. I can't wait to see what our community discovers. tinyurl.com/54u3hrj8

Large-scale high-density brain-wide neural recording in nonhuman primates - Nature Neuroscience

Neuropixels 1.0 NHP is a 45-mm, high-density silicon probe capable of recording large numbers of neurons with single-neuron resolution from most areas in a macaque’s brain.

tinyurl.com

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Gabriel Stine @gabrielmstine.bsky.social · Jun 13

This is amazing.

Nature @nature.com · Jun 12

Nature research paper: An instantaneous voice-synthesis neuroprosthesis

https://go.nature.com/4kLPolK

An instantaneous voice-synthesis neuroprosthesis - Nature

A brain-to-voice neuroprosthesis enables a man with amyotrophic lateral sclerosis to synthesize his voice in real time by decoding neural activity, demonstrating the potential of brain–computer interfaces to enable people with paralysis to speak intelligibly and expressively.

go.nature.com

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Reposted by Gabriel Stine

Cullen Lab @thecullenlab.bsky.social · May 29

The cerebellar vermis keeps us balanced by integrating sensory and motor signals. In this new review, Drs. Mildren and Cullen examine how the specialized functions of the anterior and posterior vermis contribute to postural control across a variety of contexts. www.jneurosci.org/content/45/2...

Sensorimotor Transformations for Postural Control in the Vermis of the Cerebellum

The cerebellar vermis plays an essential role in maintaining posture and balance by integrating sensory inputs from multiple modalities to effectively coordinate movement. By transforming convergent s...

www.jneurosci.org

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Reposted by Gabriel Stine

Gabriel Stine @gabrielmstine.bsky.social · May 20

A reminder that the deadline for this is coming up! Please spread the word/repost!

Gabriel Stine @gabrielmstine.bsky.social · Mar 19

The MIT BCS postdoc association in collaboration with the BCS department is excited to announce this year's rising star symposium for external postdocs! Please consider applying and send to anyone who may be interested! See the link and flyer below for more info:

mailchi.mp/be586538a6ab...

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Gabriel Stine @gabrielmstine.bsky.social · May 29

These charlatans seem to outdo their stupidity every single day.

Bill Grueskin @bgrueskin.bsky.social · May 29

RFK Jr's "MAHA" report is filled with references to studies that literally do not exist, or that completely misinterpret the studies' findings.

“We did not publish a paper.. on this topic with that co-author group, or with that title,” says one cited researcher.

www.notus.org/health-scien...

The MAHA Report Cites Studies That Don’t Exist

The Trump administration’s “Make America Healthy Again” report misinterprets some studies and cites others that don’t exist, according to the listed authors.

www.notus.org

Reposted by Gabriel Stine

Lynn Sörensen @lynnkasorensen.bsky.social · May 27

The deadline for this is ⏰THIS SATURDAY!⏰ Please consider applying and share your science with the MIT BCS community!🧠

Gabriel Stine @gabrielmstine.bsky.social · Mar 19

The MIT BCS postdoc association in collaboration with the BCS department is excited to announce this year's rising star symposium for external postdocs! Please consider applying and send to anyone who may be interested! See the link and flyer below for more info:

mailchi.mp/be586538a6ab...

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Reposted by Gabriel Stine

Ed Boyden @eboyden3.bsky.social · May 22

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Reposted by Gabriel Stine

Reza Shadmehr @rezashadmehr.bsky.social · May 22

Neuronal computation in the cerebellum via a vector calculus.

Work of Mohammad Amin Fakharian, Alden Shoup, Paul Hage, and Hisham Elseweifi

www.science.org/doi/10.1126/...

A vector calculus for neural computation in the cerebellum

Null space theory predicts that neurons generate spikes not only to produce behavior but also to prevent the undesirable effect of other neurons on behavior. In this work, we show that this competitiv...

www.science.org

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Gabriel Stine @gabrielmstine.bsky.social · May 20

A reminder that the deadline for this is coming up! Please spread the word/repost!

Gabriel Stine @gabrielmstine.bsky.social · Mar 19

The MIT BCS postdoc association in collaboration with the BCS department is excited to announce this year's rising star symposium for external postdocs! Please consider applying and send to anyone who may be interested! See the link and flyer below for more info:

mailchi.mp/be586538a6ab...

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Gabriel Stine @gabrielmstine.bsky.social · May 18

No, I mean your brain! We have some neural data and we're trying to understand how it relates to behavior. That's the process that is severely under constrained.

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Gabriel Stine @gabrielmstine.bsky.social · May 18

How are the subspaces defined? How do you know whether or not trajectories are moving through a null space with regard to the output? You still have to make assumptions about how neurons are combined/what signals are relevant to behavior/computation.

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Gabriel Stine @gabrielmstine.bsky.social · May 18

The manifold view (in its purest form) would miss this organizing principle entirely. One reason is because it doesn't actually define what a "population" is, beyond whatever neurons you happen to record from. Then, all bets are on for how this "pop." is linked to behavior. DOF = # of neurons.

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Gabriel Stine @gabrielmstine.bsky.social · May 18

An example where we've done this successfully is the primate visual system, where the receptive field of a neuron is informative about how it is combined downstream. I.e. there's a relationship between functional properties and connectivity that is critical to how we analyze and interpret data.

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Gabriel Stine @gabrielmstine.bsky.social · May 18

Not sure I agree re: manifolds, beyond it being trivial that structured connectivity will lead to the observation of manifolds. More important to identify the organizing principles of the system that constrain the link between brain & behav. In most cases this link is severely underconstrained.

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Gabriel Stine @gabrielmstine.bsky.social · May 18

Some examples:
www.science.org/doi/full/10....
www.jneurosci.org/content/29/2...
elifesciences.org/articles/67258
www.biorxiv.org/content/10.1...

www.science.org

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Reposted by Gabriel Stine

Gabriel Stine @gabrielmstine.bsky.social · May 18

Agreed. IMO, the key question is how much flexibility does the brain have to extract information that is present in the population activity? For a variety of reasons, I think this read-out is highly constrained, and so the brain figures out solutions that are robust and generalizable.

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