GAN Renyou
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GAN Renyou
@ganry.bsky.social
19 followers 12 following 41 posts
Asst. Prof. & Presidential Young Scholar, Hong Kong Polytechnic Univ.;
R&D of food functional ingredients and probiotics with translational potential;
Exec. Ed. of #iMetaOmics and #Curr.Res.Biotechnol.; Sec. EIC of #Fermentation; Exec. Assoc. Ed. of #iMeta
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Reposted by GAN Renyou
imetascience.bsky.social
🫀🦠 Gut–heart axis in #CAD: distinct microbial & metabolic shifts across normal, sCAD & ACS;
ACS signatures partly reversible.
Multi-omics #ML outperforms clinical risk factors in stratifying CAD subtypes.
🔗 onlinelibrary.wiley.com/doi/10.1002/... #microbiome
onlinelibrary.wiley.com
September 20, 2025 at 3:53 AM
Reposted by GAN Renyou
imetascience.bsky.social
🚀 317 R scripts for biomedical research, no coding barrier
⏱️ Standardized design saves time
✅ Verified, annotated, reproducible
🧬 Covers #scRNA-seq, spatial #transcriptomics, #ML & more
🔗 doi.org/10.1002/imm3...
#Bioinformatics
FigureYa: A Standardized Visualization Framework for Enhancing Biomedical Data Interpretation and Research Efficiency
FigureYa integrates 317 visualization tools across diverse biomedical domains, categorized by research type, analytical method, and output format. This resource streamlines data interpretation and en...
doi.org
September 22, 2025 at 3:29 PM
Reposted by GAN Renyou
imetascience.bsky.social
🧩 New insights into the #gut–#brain axis:
🦠L-lysine boosts barrier function & eases anxiety via tryptophan metabolism
😟H. biformis strengthens the barrier but worsens #anxiety
💻Multi-omics reveal lysine degradation as a key mechanism
🔗 doi.org/10.1002/imo2...
#microbiome #Bioinformatics
A reciprocal interaction between L‐lysine and Holdemanella biformis modulates intestinal barrier function and anxiety in irritable bowel syndrome
This study uncovers a complex interaction between l-lysine and Holdemanella biformis (H. biformis) in irritable bowel syndrome (IBS). l-lysine enhances intestinal barrier function and alleviates anxi....
doi.org
September 26, 2025 at 3:59 PM
Reposted by GAN Renyou
imetascience.bsky.social
🌏 #Soil pH shapes microbial #nitrogen cycling in Japanese forests 🌲
🧪 Acidic soils host stress-tolerant microbes retaining N
⚙️ Neutral soils favor energy-efficient taxa releasing #ammonium & driving #nitrification
🔗 doi.org/10.1002/imo2...

#SoilHealth #Microbiome #metabolism
Soil pH modulates microbial nitrogen allocation in soil via compositional and metabolic shifts across forests in Japan
This study reveals how soil pH regulates microbial N allocation in forest soils across Japan. We show that microbial abundance controls the overall rate of N cycling, while microbial composition and ...
doi.org
October 19, 2025 at 3:06 PM
Reposted by GAN Renyou
imetascience.bsky.social
🧬 Benchmarking 14 spatial clustering methods across ~600 #SpatialTranscriptomics datasets
🧫 10 technologies, 8 organs — consistent insights
⚙️ Clear guidance for method choice & preprocessing
🔗 doi.org/10.1002/imt2...
#Bioinformatics #SpatialOmics #scRNA
A comprehensive benchmarking for spatially resolved transcriptomics clustering methods across variable technologies, organs, and replicates
Spatial clustering is a critical step in spatially resolved transcriptomics. Here, we conducted a comprehensive benchmarking analysis of 14 spatial clustering methods using ~600 datasets, including b...
doi.org
October 19, 2025 at 3:14 PM
Reposted by GAN Renyou
imetascience.bsky.social
Abnormal membrane potentials & ion channel signatures drive #tumor growth, metastasis & immune evasion
💊 Ion channel drugs, tumor-treating fields & nano-delivery offer new precision therapies
🧠 Electro-immunotherapy reshapes the TME
🔗 doi.org/10.1002/imm3...
#CancerResearch #Immunotherapy
Tumor Electrophysiology in Precision Tumor Therapy
This review highlights tumor electrophysiological hallmarks as therapeutic targets in precision oncology. We examine how membrane potential alterations and ion channel fingerprints drive malignancy, ...
doi.org
October 19, 2025 at 3:18 PM
Reposted by GAN Renyou
imetascience.bsky.social
🚀 #iMeta is reshaping academic communication!
📲 Multi-platform + bilingual strategy expands global reach.
📈 1.36M full-text downloads, >10K citations, IF 33.2 (2024)!
🌐 New sub-journals & events foster a vibrant research ecosystem.
🔗 doi.org/10.1002/imt2...
#Journal
iMeta: Boosting academic sharing and collaboration via social media
Social media platforms have revolutionized scientific communication by bridging gaps between researchers, academic journals, and global audiences. This article showcases iMeta, an open-access journal...
doi.org
October 21, 2025 at 2:15 PM
Reposted by GAN Renyou
imetascience.bsky.social
🧬 New insights into the diversity of #CRISPR–Cas systems!
#Metagenomic analyses uncovered 4,112 Cas12 proteins and 6 novel subtypes.
🤖 #AI-based Cas12fam annotates 18 domains.
🌿 Cas12 subtypes show habitat-specific enrichment.
🔗 doi.org/10.1002/imo2...
#microbiome #metagenomics #bioinformatics
Metagenomic mining reveals novel Cas12 subtypes and their evolutionary diversification
We identified 4112 Cas12 Proteins and 6 new Cas12 subtypes, revealed their significant diversity in N-terminal regions, repeat sequences, and sequences motifs. We developed an AI-driven algorithm, Ca...
onlinelibrary.wiley.com
October 21, 2025 at 2:25 PM
Reposted by GAN Renyou
imetascience.bsky.social
🫀 Can plant sterols fight #atherosclerosis?
✅ Yes! #Stigmasterol reduces inflammatory macrophages & foam cells.
💡 It boosts cholesterol efflux, blocks ox-LDL uptake, and modulates AMPK/NF-κB/NLRP3 signaling.
📉 The result: less vascular #inflammation, healthier arteries.
🔗 doi.org/10.1002/imo2...
Stigmasterol attenuates atherosclerosis by inhibiting inflammatory signaling and foam cell formation
Stigmasterol mitigates atherosclerotic plaque formation by modulating foam cell phenotypic alterations and cholesterol metabolism. Stigmasterol inhibits inflammatory CD86+ macrophage polarization via...
doi.org
October 21, 2025 at 2:29 PM
Reposted by GAN Renyou
imetascience.bsky.social
🌱 What shapes the chemotypes of Atractylodes lancea?
Not genes alone!
🧬 Genetic divergence follows altitude & climate.
🌾 #Soil and #microbiome together tune its metabolite profiles.
🦠 Core #rhizosphere & endophytic microbes hold the key.
🔗 doi.org/10.1002/imo2...
The combined influence of microbiome and soil environment contributes to the chemotype differentiation in Atractylodes lancea
Genetic differentiation between the Maoshan-Dabie Mountains group (MA genotype) and Qinling-Taihang Mountains group (SA genotype) of Atractylodes lancea occurs along altitude and climatic gradients. ....
doi.org
October 22, 2025 at 3:08 PM
Reposted by GAN Renyou
imetascience.bsky.social
🍩 What happens when Prmt5 is lost in fat cells?
🧬 Lipid genes go down, #glucose metabolism goes up!
💥 #Triglycerides drop while phospholipid & sphingolipid diversity expands.
PRMT5 emerges as a key regulator of membrane transport & #cholesterol synthesis.
🔗 doi.org/10.1002/imo2...
Multiomics analyses reveal that PRMT5 regulates membrane transport and cholesterol synthesis in white adipocytes
Prmt5AKO downregulates genes related to fatty acid transport and triacylglycerol synthesis, while upregulating genes involved in glucose transport and cholesterol biogenesis. These changes cause alte...
doi.org
October 22, 2025 at 3:22 PM
Reposted by GAN Renyou
imetascience.bsky.social
💡 30 scientific recommendations from the #CHINAGUT Conference!
👩‍🔬 63 experts joined forces to shape the future of:
🦠 #Probiotics
💊 Live biotherapeutic products
💩 #FMT
The goal: standardization, regulation & precision in #microbiome-based therapies.
🔗 doi.org/10.1002/imt2...
October 22, 2025 at 3:26 PM
Reposted by GAN Renyou
imetascience.bsky.social
💥 Can AI solve the #antibiotic resistance crisis?
🤖 By revolutionizing every step of drug discovery—from target ID to lead optimization.
🧬 Two paths: molecular screening & de novo design.
⚙️ #AI accelerates discovery, boosts ADMET prediction & drives multi-target innovation.
🔗 doi.org/10.1002/imm3...
Artificial Intelligence Revolutionizes Anti‐Infective Drug Discovery: From Target Identification to Lead Optimization
Artificial intelligence (AI) technology is revolutionizing antimicrobial drug development. In response to increasingly severe antimicrobial resistance challenges, AI can efficiently predict pathogen ...
doi.org
October 27, 2025 at 3:21 PM
Reposted by GAN Renyou
imetascience.bsky.social
🌟 #iMeta Conference 2025
🧬 Focus: #Microbiology, #medicine, #TCM, #plant science & research talent development
🤝 Empowering innovation & advancing journals globally
🔗 onlinelibrary.wiley.com/doi/10.1002/...
#Bioinformatics #microbiome #metagenomics
iMeta Conference 2025: Creating high‐impact international journals
The iMeta Conference 2025, part of the iMeta Conference series, themed “Creating High-Impact International Journals,” held at the Huangjiahu Campus of Hubei University of Chinese Medicine from August...
onlinelibrary.wiley.com
October 27, 2025 at 3:28 PM
Reposted by GAN Renyou
imetascience.bsky.social
🐶💩 Humans and dogs share more than companionship — their gut microbes evolve together!
🧬 Dogs’ gut microbiomes show greater functional similarity to humans than macaques do.
🔗 onlinelibrary.wiley.com/doi/10.1002/...
#microbiome #metabolism
Convergent evolution of metabolic functions: Evidence from the gut microbiomes of humans and dogs
Dogs have undergone convergent evolution in their genome with humans in long-term co-living. Studies have shown that the gut microbiomes of dogs exhibit greater similarity to those of humans compared...
onlinelibrary.wiley.com
October 27, 2025 at 3:40 PM
Reposted by GAN Renyou
imetascience.bsky.social
🐭 #Lactiplantibacillus plantarum Hi188 promotes post-weaning growth in mice.
🧪 The #metabolite 5-HIAA activates hepatic #AhR, boosting IGF-1 production.
🧑‍💻 Metagenomic and host transcriptome data reveal that 5-HIAA is co-produced by the host–microbiota axis.
🔗 doi.org/10.1002/imo2...
#microbiome
Host–microbiota interaction drives 5‐hydroxyindole‐3‐acetic acid production to promote linear growth in infant mice
This study discovered that Lactiplantibacillus plantarum Hi188 promoted linear growth in postweaning mice. Transcriptomic analysis, untargeted metabolomics, and in vitro experiments showed that the e...
doi.org
October 30, 2025 at 3:06 PM
Reposted by GAN Renyou
imetascience.bsky.social
🧬 CycloneSEQ #nanopore sequencing rapidly reconstructs multidrug-resistant bacterial genomes!
⚙️ 96.16% read accuracy, 99.98% assembly accuracy.
💡 Complete genomes with just 15× long reads or 5× hybrid data.
🔗 onlinelibrary.wiley.com/doi/10.1002/...
#Bioinformatics #BGI
October 30, 2025 at 3:20 PM
Reposted by GAN Renyou
imetascience.bsky.social
🌸 Profiling 6423 Chinese women, this study uncovers a midlife shift in the #vaginal #microbiota—
⚖️ Decline of #Lactobacillus crispatus, rise of #Gardnerella vaginalis around age 40.
🧠 A new #microbiome balance score predicts reproductive health risks.
🔗 doi.org/10.1002/imt2...
Nationwide profiling of vaginal microbiota in Chinese women reveals age‐dependent shifts and predictive biomarkers for reproductive health
The vaginal microbiome is central to reproductive health, yet large-scale studies in East Asian populations remain scarce. Here, we characterized the vaginal microbiota of 6423 Chinese women of repro...
doi.org
October 30, 2025 at 3:24 PM
Reposted by GAN Renyou
imetascience.bsky.social
🧬 GSE-Seq — high-throughput single-entity sequencing via droplet microfluidics!
⚙️ Integrates #barcode generation, degradable hydrogel processing & long-read #sequencing — uncovering vast microbial “dark matter.”
🔗https://doi.org/10.1002/imt2.70087
November 14, 2025 at 8:07 AM
Reposted by GAN Renyou
imetascience.bsky.social
Gut–X axis - Lin - 2025 - iMeta - Wiley Online Library onlinelibrary.wiley.com/doi/full/10....
December 2, 2025 at 12:16 PM
Reposted by GAN Renyou
imetascience.bsky.social
Whole #microbiota transplantation restores gut homeostasis throughout the #gastrointestinal tract - Tang - iMeta - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
December 2, 2025 at 12:29 PM
Reposted by GAN Renyou
imetascience.bsky.social
🧬 CRISPR screen uncovers C9ORF50 as a key regulator of #cancer immune evasion!
⚙️ Blocking this splicing factor triggers #dsRNA buildup, Type I IFN activation & strong T-cell recruitment.
onlinelibrary.wiley.com/doi/10.1002/...
Genome‐wide CRISPR screen reveals an uncharacterized spliceosome regulator as new candidate immunotherapy target
This study identifies the uncharacterized gene C9ORF50 as a novel regulator of immune evasion. Functioning as an intrinsically disordered protein, C9ORF50 drives liquid-liquid phase separation to fac...
onlinelibrary.wiley.com
December 3, 2025 at 9:18 AM
Reposted by GAN Renyou
imetascience.bsky.social
🫁🔥 HDM-activated #bronchial #fibroblasts emerge as key drivers of airway #inflammation in allergic #asthma!
⚙️ Bronchial fibroblasts are not only structural cells but also direct responders to #allergens.
onlinelibrary.wiley.com/doi/10.1002/...
Bronchial Fibroblasts Respond to House Dust Mite Challenge With Cytokine Secretion: Role in Allergic Airway Inflammation
Schematic of the early-stage characteristics of house dust mites-induced bronchial fibroblasts, which are characterized by suppressed extracellular matrix production alongside activated inflammatory ...
onlinelibrary.wiley.com
December 3, 2025 at 10:31 AM
Reposted by GAN Renyou
imetascience.bsky.social
🫁Immune–transcriptomic profiling uncovers a four-gene model AUC 0.94 for lung cancer with pulmonary tuberculosis!
💡#MTB remodels #tumor #microenvironment via metabolic-immune crosstalk.
⚡First #immune-transcriptomic map of #lung cancer plus tuberculosis.
onlinelibrary.wiley.com/doi/10.1002/...
Immunometabolic Features and Key Biomarkers in Lung Cancer Complicated by Pulmonary Tuberculosis: Insights From Transcriptome and Clinical Cohort Analysis
Integrative analysis of LC-PTB patients pinpoints six biomarkers (ANK2, EPB42, CA1, HBB, HBD, MYL4) that reshape the immune microenvironment, offering new targets for diagnosis and treatment of lung ...
onlinelibrary.wiley.com
December 7, 2025 at 7:29 AM
Reposted by GAN Renyou
imetascience.bsky.social
🧠 Copper exposure drives #neurotoxicity through a gut–brain metabolic axis!
🔥 It triggers #gut barrier damage and inflammation, leading to #neural injury.
💊 The #probiotic W. coagulans XY2 counteracts toxicity by targeting a multi-layered network.
onlinelibrary.wiley.com/doi/10.1002/...
Weizmannia coagulans XY2 Mitigates Copper Neurotoxicity via Gut–Brain Axis Modulation of Tryptophan Metabolism and Oxidative‐Inflammatory Crosstalk
Copper interferes with tryptophan metabolism and 5-HT levels by modulating intestinal flora. Intestinal barrier breakdown and inflammatory response trigger nerve damage under copper exposure. W. coag...
onlinelibrary.wiley.com
December 7, 2025 at 7:44 AM