GastroAGI
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Empowering clinicians & trainees with expert GI & liver updates, clinical pearls & trending research.
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GastroAGI | January 2026 Updates
Explore the latest high-impact research in gastroenterology and hepatology from leading journals. Log in, click Trending Topics, and stay updated with January 2026 insights.
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Explore the latest high-impact research in gastroenterology and hepatology from leading journals. Log in, click Trending Topics, and stay updated with January 2026 insights.
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MAPK signaling drives GI disease: ERK promotes tumor growth in CRC & gastric cancer; JNK & p38 drive inflammation, apoptosis & fibrosis in IBD and pancreatitis. Targeted MEK, JNK & p38 inhibitors show promise, but resistance and off-target effects remain challenges.
#gastroenterology
#gastroenterology
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January 16, 2026 at 11:24 AM
MAPK signaling drives GI disease: ERK promotes tumor growth in CRC & gastric cancer; JNK & p38 drive inflammation, apoptosis & fibrosis in IBD and pancreatitis. Targeted MEK, JNK & p38 inhibitors show promise, but resistance and off-target effects remain challenges.
#gastroenterology
#gastroenterology
🔬 THR-β agonists are reshaping MASH therapy. 📌 Resmetirom (MAESTRO-NASH) improved MASH resolution & fibrosis vs placebo and ↓ liver fat with better lipids. 🧪 VK2809 shows similar fat reduction. ⚠️ Long-term & cirrhosis outcomes pending, but THR-β is now validated.
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January 16, 2026 at 11:23 AM
🔬 THR-β agonists are reshaping MASH therapy. 📌 Resmetirom (MAESTRO-NASH) improved MASH resolution & fibrosis vs placebo and ↓ liver fat with better lipids. 🧪 VK2809 shows similar fat reduction. ⚠️ Long-term & cirrhosis outcomes pending, but THR-β is now validated.
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ACLF East vs West: APASL—acute insult in CLD → jaundice/INR, liver failure first; HBV common; focus on liver rescue (antivirals, PE, albumin). AASLD/CLIF—decomp cirrhosis w/ multiorgan failure; sepsis/alcohol common; ICU + early LT. Synthesis needed.
#GastroAGI#AASLD2025#ACLF
#GastroAGI#AASLD2025#ACLF
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January 16, 2026 at 11:23 AM
ACLF East vs West: APASL—acute insult in CLD → jaundice/INR, liver failure first; HBV common; focus on liver rescue (antivirals, PE, albumin). AASLD/CLIF—decomp cirrhosis w/ multiorgan failure; sepsis/alcohol common; ICU + early LT. Synthesis needed.
#GastroAGI#AASLD2025#ACLF
#GastroAGI#AASLD2025#ACLF
🔥 TGF-β in chronic pancreatitis: key driver of fibrosis via pancreatic stellate cell activation. 🧬 Promotes collagen deposition, EMT & profibrotic immune responses. 💊 Targeting TGF-β (pirfenidone, NAC, blockers) shows antifibrotic promise.
#gastroenterology
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#gastroenterology
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January 16, 2026 at 11:22 AM
🔥 TGF-β in chronic pancreatitis: key driver of fibrosis via pancreatic stellate cell activation. 🧬 Promotes collagen deposition, EMT & profibrotic immune responses. 💊 Targeting TGF-β (pirfenidone, NAC, blockers) shows antifibrotic promise.
#gastroenterology
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#gastroenterology
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🔬 Machine perfusion in liver transplant keeps donor livers metabolically active. ❄️ HMP reduces ischemia. 🌡️ NMP enables real-time functional assessment. 🧠 Allows use of steatotic, DCD & elderly grafts. 📈 Expands donor pool. 🔮 Future: organ repair, gene therapy & improved logistics.
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January 16, 2026 at 11:20 AM
🔬 Machine perfusion in liver transplant keeps donor livers metabolically active. ❄️ HMP reduces ischemia. 🌡️ NMP enables real-time functional assessment. 🧠 Allows use of steatotic, DCD & elderly grafts. 📈 Expands donor pool. 🔮 Future: organ repair, gene therapy & improved logistics.
PERT in EPI (ACG): Start PERT at diagnosis—don’t wait for severe sx or deficits. Multidisciplinary care incl nutrition + endo. Diet: low–moderate fat, small frequent meals; screen vitamins annually. Dx: fecal elastase best; imaging not diagnostic. Monitor nutrition + DEXA q1–2y.
#gastroenterology
#gastroenterology
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January 16, 2026 at 11:19 AM
PERT in EPI (ACG): Start PERT at diagnosis—don’t wait for severe sx or deficits. Multidisciplinary care incl nutrition + endo. Diet: low–moderate fat, small frequent meals; screen vitamins annually. Dx: fecal elastase best; imaging not diagnostic. Monitor nutrition + DEXA q1–2y.
#gastroenterology
#gastroenterology
Pancreatic SBRT shows low 90-day mortality. 🦠 Infections drive many admissions. ⚠️ Late severe GI toxicity is higher without prior surgery and with high-BED dosing. 🔎 Future SBRT trials need long-term follow-up to capture late toxicities.
#gastroenterology
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#gastroenterology
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January 16, 2026 at 11:18 AM
Pancreatic SBRT shows low 90-day mortality. 🦠 Infections drive many admissions. ⚠️ Late severe GI toxicity is higher without prior surgery and with high-BED dosing. 🔎 Future SBRT trials need long-term follow-up to capture late toxicities.
#gastroenterology
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#gastroenterology
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January 16, 2026 at 10:30 AM
Programmed cell death inhibitors in liver disease: Apoptosis blockers ↓ hepatocyte loss but need cancer monitoring. (RIPK1/3) inhibitors ↓ inflammation & fibrosis in MASLD/MASH.NLRP3 inhibitors ↓ IL-1β/IL-18. Ferroptosis inhibitors limit lipid peroxidation in MASH & I/R.
#gastroenterology
#gastroenterology
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January 16, 2026 at 9:58 AM
Programmed cell death inhibitors in liver disease: Apoptosis blockers ↓ hepatocyte loss but need cancer monitoring. (RIPK1/3) inhibitors ↓ inflammation & fibrosis in MASLD/MASH.NLRP3 inhibitors ↓ IL-1β/IL-18. Ferroptosis inhibitors limit lipid peroxidation in MASH & I/R.
#gastroenterology
#gastroenterology
Endothelial cells control liver zonation & regeneration: Zone 1 LSECs make Wnt inhibitors → gluconeogenesis & oxidative metabolism. Zone 3 LSECs make Wnt2/Wnt9b → detox & lipid metabolism. Injury: LSECs release HGF, VEGF & Wnt. Damage impairs repair, promotes fibrosis.
#gastroenterology
#gastroenterology
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January 16, 2026 at 9:50 AM
Endothelial cells control liver zonation & regeneration: Zone 1 LSECs make Wnt inhibitors → gluconeogenesis & oxidative metabolism. Zone 3 LSECs make Wnt2/Wnt9b → detox & lipid metabolism. Injury: LSECs release HGF, VEGF & Wnt. Damage impairs repair, promotes fibrosis.
#gastroenterology
#gastroenterology
miR147 protects gut mucosa by maintaining epithelial integrity and limiting inflammation. Knockout causes severe colitis, barrier loss, ↑ permeability. Targets Ndufa4 to regulate metabolism + type I IFN signaling. Therapeutic potential in IBD & colorectal cancer.
#gastroenterology
#gastroenterology
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January 16, 2026 at 9:49 AM
miR147 protects gut mucosa by maintaining epithelial integrity and limiting inflammation. Knockout causes severe colitis, barrier loss, ↑ permeability. Targets Ndufa4 to regulate metabolism + type I IFN signaling. Therapeutic potential in IBD & colorectal cancer.
#gastroenterology
#gastroenterology
COBALT (PBC): Despite early termination, adjusted analyses + real-world external controls showed obeticholic acid reduced major liver events. EC analysis showed lower risk of death, LT, or decompensation. Well tolerated; pruritus most common. Shows value of hybrid RCT + RWE.
#gastroenterology
#gastroenterology
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January 16, 2026 at 9:48 AM
COBALT (PBC): Despite early termination, adjusted analyses + real-world external controls showed obeticholic acid reduced major liver events. EC analysis showed lower risk of death, LT, or decompensation. Well tolerated; pruritus most common. Shows value of hybrid RCT + RWE.
#gastroenterology
#gastroenterology
ML is transforming GI endoscopy: CADe boosts adenoma detection. CADx improves lesion classification & risk prediction. AI automates image analysis, annotation & reporting. Challenges: bias, artefacts, expert labels, real-time use. Future: LLMs+CV for precision & scalability.
#gastroenterology
#gastroenterology
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January 16, 2026 at 9:47 AM
ML is transforming GI endoscopy: CADe boosts adenoma detection. CADx improves lesion classification & risk prediction. AI automates image analysis, annotation & reporting. Challenges: bias, artefacts, expert labels, real-time use. Future: LLMs+CV for precision & scalability.
#gastroenterology
#gastroenterology
January 16, 2026 at 7:41 AM
An SVM-based ML model predicts postoperative recurrence in ESCC. Using clinical, lab, and pathologic factors, the SVM6+8 model achieved high sensitivity. A nomogram estimates 1-, 3-, 5-yr DFS, enabling risk stratification and personalized follow-up/adjuvant therapy.
#gastroenterology
#gastroenterology
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January 15, 2026 at 11:58 AM
An SVM-based ML model predicts postoperative recurrence in ESCC. Using clinical, lab, and pathologic factors, the SVM6+8 model achieved high sensitivity. A nomogram estimates 1-, 3-, 5-yr DFS, enabling risk stratification and personalized follow-up/adjuvant therapy.
#gastroenterology
#gastroenterology
📘 Chicago Classification v4.0 tightens HRM interpretation with mandatory clinical correlation. Supine + upright swallows required. EGJOO needs ↑IRP in both + abnormal confirmatory test. Achalasia, DES, Jackhammer require symptoms + supportive tests.
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#gasteroenterology
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#gasteroenterology
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January 15, 2026 at 11:56 AM
📘 Chicago Classification v4.0 tightens HRM interpretation with mandatory clinical correlation. Supine + upright swallows required. EGJOO needs ↑IRP in both + abnormal confirmatory test. Achalasia, DES, Jackhammer require symptoms + supportive tests.
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#gasteroenterology
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#gasteroenterology
⚠ Ultra-processed foods (UPFs) & early death: Higher UPF intake is linked to increased mortality. Countries with very high UPF consumption show more premature deaths. Experts urge taxes, clearer labeling, and better access to healthy foods.
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January 15, 2026 at 11:55 AM
⚠ Ultra-processed foods (UPFs) & early death: Higher UPF intake is linked to increased mortality. Countries with very high UPF consumption show more premature deaths. Experts urge taxes, clearer labeling, and better access to healthy foods.
🧠 gastroagi.com/chat
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🔪 Two-stage hepatectomy (TSH): option for initially unresectable colorectal liver mets. 🩺 Stage 1: debulk tumors + liver regeneration. 🩸 Stage 2: resect residual disease after FLR hypertrophy. Enables long-term survival, potential cure.
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January 15, 2026 at 11:54 AM
🔪 Two-stage hepatectomy (TSH): option for initially unresectable colorectal liver mets. 🩺 Stage 1: debulk tumors + liver regeneration. 🩸 Stage 2: resect residual disease after FLR hypertrophy. Enables long-term survival, potential cure.
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Autoantibodies in MASLD (ANA, ASMA) are common and signal worse prognosis: higher risk of liver decompensation and mortality. They mark immune activation, predict progression to cACLD, and support risk stratification and closer monitoring. #GastroAGI #MASLD #Liver
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January 15, 2026 at 11:52 AM
Autoantibodies in MASLD (ANA, ASMA) are common and signal worse prognosis: higher risk of liver decompensation and mortality. They mark immune activation, predict progression to cACLD, and support risk stratification and closer monitoring. #GastroAGI #MASLD #Liver
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📏 FLIP panometry—Dallas Consensus: Experts standardized 40 guidelines to reduce variability. Normal FLIP reliably rules out major motility disorders. ↓EGJ opening with weak contractions suggests EGJ outflow obstruction. Major step toward uniform global practice.
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January 13, 2026 at 12:59 PM
📏 FLIP panometry—Dallas Consensus: Experts standardized 40 guidelines to reduce variability. Normal FLIP reliably rules out major motility disorders. ↓EGJ opening with weak contractions suggests EGJ outflow obstruction. Major step toward uniform global practice.
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🔥 HbA1c & infected pancreatic necrosis: HbA1c ≥6.5% confers ~4× higher IPN risk in acute necrotizing pancreatitis. Hyperglycemia drives immune dysfunction, bacterial translocation & inflammation. Early HbA1c testing and strict glucose control are key.
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January 13, 2026 at 12:58 PM
🔥 HbA1c & infected pancreatic necrosis: HbA1c ≥6.5% confers ~4× higher IPN risk in acute necrotizing pancreatitis. Hyperglycemia drives immune dysfunction, bacterial translocation & inflammation. Early HbA1c testing and strict glucose control are key.
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🔆 Radiotherapy in HCC: Y90 vs SBRT—Y90 delivers heterogeneous microsphere radiation (2–3 mm, days; t½ ~64 h), reducing biologic effect per Gy. SBRT gives uniform, precise high-dose in minutes. ~400 Gy Y90 ≈ 40–50 Gy SBRT.
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January 13, 2026 at 12:58 PM
🔆 Radiotherapy in HCC: Y90 vs SBRT—Y90 delivers heterogeneous microsphere radiation (2–3 mm, days; t½ ~64 h), reducing biologic effect per Gy. SBRT gives uniform, precise high-dose in minutes. ~400 Gy Y90 ≈ 40–50 Gy SBRT.
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🧬 Chronic pancreatitis markedly increases pancreatic cancer risk (~8×), higher than acute pancreatitis. Risk is greatest for PDAC and IPMN. CP patients should be considered high-risk, supporting targeted screening strategies.
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January 13, 2026 at 12:58 PM
🧬 Chronic pancreatitis markedly increases pancreatic cancer risk (~8×), higher than acute pancreatitis. Risk is greatest for PDAC and IPMN. CP patients should be considered high-risk, supporting targeted screening strategies.
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🫀 LT for CRLM: Multicenter data show strong survival (1–5y OS 94/73/55%). Women had ~4× higher mortality, linked to right-sided tumors, KRAS mutations & ↑ liver recurrence. Poor prognostic factors: CEA >80, large nodules, pN2. Sex-aware selection needed.
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January 13, 2026 at 12:58 PM
🫀 LT for CRLM: Multicenter data show strong survival (1–5y OS 94/73/55%). Women had ~4× higher mortality, linked to right-sided tumors, KRAS mutations & ↑ liver recurrence. Poor prognostic factors: CEA >80, large nodules, pN2. Sex-aware selection needed.
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🌬️ Breath biopsy in cirrhosis: Noninvasive VOC analysis. Seven VOCs (e.g., limonene, 2-pentanone, indole) detected cirrhosis with AUC 0.95. Reflects impaired CYP/detox pathways & gut–liver axis. VOC profiles correlate with Child-Pugh stage—promising for early detection & staging
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January 13, 2026 at 12:57 PM
🌬️ Breath biopsy in cirrhosis: Noninvasive VOC analysis. Seven VOCs (e.g., limonene, 2-pentanone, indole) detected cirrhosis with AUC 0.95. Reflects impaired CYP/detox pathways & gut–liver axis. VOC profiles correlate with Child-Pugh stage—promising for early detection & staging
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